Browse our DEFa3 Proteins (DEFa3)

Full name:
Defensin, alpha 3, Neutrophil-Specific Proteins (DEFa3)
On www.antibodies-online.com are 6 Defensin, alpha 3, Neutrophil-Specific (DEFa3) Proteins from 5 different suppliers available. Additionally we are shipping DEFa3 Antibodies (27) and DEFa3 Kits (7) and many more products for this protein. A total of 42 DEFa3 products are currently listed.
Synonyms:
DEF3, DEFA1, DEFA3, Defa27, Defcr-3, Defcr3, DEFT1P, HNP-3, HNP3, HP-3, HP3
list all proteins Gene Name GeneID UniProt
DEFa3 613253  
Mouse DEFa3 DEFa3 13237 P28310

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DEFa3 Proteins (DEFa3) by Origin

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Human Defensin, alpha 3, Neutrophil-Specific (DEFa3) interaction partners

  1. these results demonstrate that HNPs1-3 may be potent inhibitors of ADAMTS13 (show ADAMTS13 Proteins) activity, likely by binding to the central A2 domain of VWF (show VWF Proteins) and physically blocking ADAMTS13 (show ADAMTS13 Proteins) binding.

  2. we found that DEFA1A3 is expressed in renal epithelium and not restricted to myeloid-derived cells, such as neutrophils. In conclusion, low DEFA1A3 copy number associated with recurrent urinary tract infections in subjects in the RIVUR Study randomized to prophylactic antibiotics, providing evidence that copy number polymorphisms in an antimicrobial peptide (show cAMP Proteins) associate with urinary tract infection risk

  3. High HNP3 expression is associated with IgA Nephropathy.

  4. RTD-1 reduced the secretion of tumor necrosis factor-alpha (TNF-alpha (show TNF Proteins)), interleukin (IL)-1beta (show IL1B Proteins), and IL-8 (show IL8 Proteins) in lipopolysaccharide (LPS (show IRF6 Proteins))-stimulated human blood monocytes and THP-1 macrophages

  5. Elevated DEFA3 levels in diabetes are independent of DEFA3 copy numbers.

  6. DEFA3 encodes an antibacterial peptide that is bacteriocidal against S. aureus, E. coli, and P. aeruginosa.

  7. A decrease in salivary HNP 1 (show DEFA1 Proteins)-3 levels might be a biological factor for predisposition to oral ulcers in patients with Behcet disease and oral infection in healthy patients.

  8. Results indicate that the gene expression of DEFA 1 (show DEFA1 Proteins)/3 and 4 was significantly increased in all tumours - except for a significant decrease of DEFA 4 (show DEFA4 Proteins) gene expression in pleomorphic adenomas.

  9. DEFA1A3 copy numbers did not differ significantly between systemic lupus erythematosus patients and controls. DEFA1A3 copy numbers ranged from 3 to 11 in Han Chinese in Beijing and 4 to 16 in Japanese in Tokyo.

  10. alpha-Defensin (show DEF Proteins) (DEFA3)was the third most differentially overexpressed gene and may be related to the onset of Bell's palsy and Ramsay Hunt Syndrome.

Mouse (Murine) Defensin, alpha 3, Neutrophil-Specific (DEFa3) interaction partners

  1. MMP-7 (show MMP7 Proteins)-dependent procryptdin activation in vivo provides mouse Paneth cells with functional peptides for apical secretion into the small intestine lumen

  2. cryptdin 3 forms anion-selective channels on the cytoplasmic membrane of HEK (show EPHA3 Proteins) cells and that the kinetics of one such channel are affected by its interaction with other such channels.

DEFa3 Protein Profile

Protein Summary

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation.

Alternative names and synonyms associated with DEFa3

  • defensin, alpha 3, neutrophil-specific (DEFA3)
  • alpha-defensin 1A (MNP1A)
  • defensin, alpha 1 and alpha 3, variable copy number locus (DEFA1A3)
  • defensin, alpha, 3 (Defa3)
  • DEF3 protein
  • DEFA1 protein
  • DEFA3 protein
  • Defa27 protein
  • Defcr-3 protein
  • Defcr3 protein
  • DEFT1P protein
  • HNP-3 protein
  • HNP3 protein
  • HP-3 protein
  • HP3 protein

Protein level used designations for DEFa3

neutrophil defensin 3 , Paneth cell-specific alpha-defensin 3 , alpha-defensin 3, neutrophil-specific , Neutrophil defensin 1 , Neutrophil defensin 3 , RMAD-1 , RMAD-3 , RMAD-8 , neutrophil defensin 8 , defensin 3, neutrophil-specific , neutrophil peptide 3 , alpha-defensin 3 , defensin, alpha, 27 , defensin-related cryptdin-3

GENE ID SPECIES
100307025 Equus caballus
574196 Macaca mulatta
613253 Homo sapiens
1668 Homo sapiens
13237 Mus musculus
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