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Human FCGR2B Protein expressed in Wheat germ - ABIN1353899
Sakamoto, Ito, Hatanaka, Soni, Mori, Sugimura: Discovery and characterization of a peptide motif that specifically recognizes a non-native conformation of human IgG induced by acidic pH conditions. in The Journal of biological chemistry 2009
Human FCGR2B Protein expressed in Human Cells - ABIN2002450
Ravetch, Lanier: Immune inhibitory receptors. in Science (New York, N.Y.) 2000
Show all 5 Pubmed References
Gene copy number variation (CNV) of the PKLR (show PKLR Proteins), FCGR2A (show FCGR2A Proteins), FCGR2C, and FCGR3 (show CD16 Proteins) genes is associated with malaria severity, and our results provide evidence for a role of CNV in host responses to malaria.
results indicate that FcgammaRIIB is not uniquely able to promote membrane recruitment of SHIP, but rather modulates its function via formation of distinct signaling complexes. Membrane recruitment of SHIP via Syk (show SYK Proteins)-dependent mechanisms may be an important factor modulating immunoreceptor signaling.
FCGR2A (show FCGR2A Proteins) and FCGR2C polymorphisms may also contribute to immunocomplexemia present in sarcoidosis.
Fc gamma receptor IIb was significantly elevated in abdominal aortic aneurysm (AAA (show APP Proteins)) tissues compared to normal aortas. Fc gamma receptor IIb may be involved in the pathogenesis of AAA (show APP Proteins) by regulation of inflammatory reactions.
Fc-gamma receptor (show FCGR1A Proteins) polymorphisms differentially influence susceptibility to systemic lupus erythematosus and lupus nephritis.
FCGR2C SNPs that associated with vaccine efficacy in RV144 also strongly associated with the expression of FCGR2A (show FCGR2A Proteins)/C and one of them also associated with the expression of Fc receptor-like A (FCRLA (show FCRLA Proteins)), another Fc-gamma receptor (show FCGR1A Proteins) (FcgammaR) gene
LPS (show IRF6 Proteins) activation of TLR4 (show TLR4 Proteins) significantly increased MARCH3 (show MARCH3 Proteins) expression and that siRNA against MARCH3 (show MARCH3 Proteins) prevented the decrease in FcgammaRIIb following LPS (show IRF6 Proteins) treatment.
a rare FCGR2B null-variant allele was found, in which a polymorphic stop codon of FCGR2C is introduced into one FCGR2B gene
Data show that gains or losses in copy numbers of Fc gamma receptors FCGR3A (show CD16 Proteins) were less frequent than for FCGR3B (show CD16 Proteins) and FCGR2C.
FcgammaRIIB requires Btk (show BTK Proteins) and p38 MAPK (show MAPK14 Proteins) to mediate antigen-independent inhibition in human B cells.
PLCd1 (show PLCD1 Proteins) negatively regulates lipopolysaccharide-induced production of IL-1b (show IL1B Proteins) and Fc gamma receptor (show FCGR1A Proteins)-mediated phagocytosis in macrophages.
The authors concluded that the FcgammaRIIb-SHIP2 (show INPPL1 Proteins) axis links Abeta (show APP Proteins) neurotoxicity to tau pathology by dysregulating phosphoinositide metabolism, providing insight into therapeutic potential against Alzheimer's disease.
This study reports the creation of a mouse model of autoimmunity-associated atherosclerosis by transplanting bone marrow from FcgammaRIIB knockout (FcRIIB(-/-)) mice into LDL receptor (show LDLR Proteins) knockout mice.
These results reveal a novel and unexpected function of hepatic Fc-gamma-RIIB in the targeted downregulation of GPVI (show GP6 Proteins) in vivo.
Cytokine release was quantified from FVIII(-/-) splenocytes restimulated with FVIII in the absence or presence of different anti-FcgammaRIIB (CD32) Antibodies (anti-CD32 mAbs) over 6 days.
Collectively these findings reveal that by inhibiting eNOS (show NOS3 Proteins), endothelial FcgammaRIIB activation by CRP (show CRP Proteins) blunts insulin (show INS Proteins) delivery to skeletal muscle to cause insulin (show INS Proteins) resistance.
Macrophages' activating FcgammaR expression profile are associated with the development of ITP (show ITPA Proteins) in Treg-deficient mice.
this study shows that FcgammaRIIb drives the sequential dephosphorylation system comprising SHIP1 (show INPP5D Proteins)/2 and Inpp4a (show INPP4A Proteins), and accelerates phagosome acidification
CD32 is a crucial regulator of FVIII (show F8 Proteins)-specific B cells and is required for the differentiation of memory B cells into antibody-secreting cells.
Aggregated alpha-Synuclein (alpha-syn) inhibited microglial phagocytosis. The inhibitory effect of aggregated alpha-syn on microglial phagocytosis was due to the activation of SHP-1 and FcgammaRIIB on microglia.
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
, Fc fragment of IgG, low affinity II, receptor for (CD32)
, Fc fragment of IgG, low affinity IIb, receptor for (CD32)
, Fc gamma RIIb
, fc-gamma RII-b
, igG Fc receptor II-b
, low affinity immunoglobulin gamma Fc region receptor II-b
, Fc fragment of IgG, low affinity IIb, receptor (CD32)
, Fc fragment of IgG, low affinity IIb, receptor
, IgG Fc gamma receptor II
, Fc gamma RIIB
, fc gamma receptor IIB
, fc-gamma RII
, igG Fc receptor II beta
, low affinity immunoglobulin gamma Fc region receptor II
, lymphocyte antigen 17
, FC-gamma RII
, Fc receptor, IgG, low affinity IIb
, low affinity immunoglobulin gamma FC region receptor II
, Fc gamma receptor II