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Browse our FCGR2B Proteins (FCGR2B)

Full name:
Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) Proteins (FCGR2B)
On are 24 Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) Proteins from 9 different suppliers available. Additionally we are shipping FCGR2B Antibodies (85) and FCGR2B Kits (19) and many more products for this protein. A total of 147 FCGR2B products are currently listed.
AI528646, CD32, CD32B, F630109E10Rik, FCG2, Fcgr2, Fcgr2a, FCGR2B, FcgRII, Fcr-2, Fcr-3, Fc[g]RII, IGFR2, Ly-17, Ly-m20, Lym-1
list all proteins Gene Name GeneID UniProt
FCGR2B 2213 P31994
FCGR2B 14130 P08101

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FCGR2B Proteins (FCGR2B) by Origin

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Top referenced FCGR2B Proteins

  1. Human FCGR2B Protein expressed in Baculovirus infected Insect Cells - ABIN2002455 : Ravetch, Lanier: Immune inhibitory receptors. in Science (New York, N.Y.) 2000 (PubMed)
    Show all 4 references for ABIN2002455

  2. Cynomolgus FCGR2B Protein expressed in Baculovirus infected Insect Cells - ABIN2009711 : Rankin, Veri, Gorlatov, Tuaillon, Burke, Huang, Inzunza, Li, Thomas, Johnson, Stavenhagen, Koenig, Bonvini: CD32B, the human inhibitory Fc-gamma receptor IIB, as a target for monoclonal antibody therapy of B-cell lymphoma. in Blood 2006 (PubMed)
    Show all 4 references for ABIN2009711

  3. Cynomolgus FCGR2B Protein expressed in Human Cells - ABIN2009708 : Brooks, Qiu, Luster, Ravetch: Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes. in The Journal of experimental medicine 1989 (PubMed)
    Show all 4 references for ABIN2009708

  4. Rat (Rattus) FCGR2B Protein expressed in Human Cells - ABIN2009038 : Takai: Roles of Fc receptors in autoimmunity. in Nature reviews. Immunology 2002 (PubMed)
    Show all 4 references for ABIN2009038

  5. Human FCGR2B Protein expressed in HEK-293 Cells - ABIN2180754 : Hamada, Aoki, Akiyama, Toyoshima: Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)
    Show all 3 references for ABIN2180754

  6. Human FCGR2B Protein expressed in Escherichia coli (E. coli) - ABIN1098464 : Baerenwaldt, Lux, Danzer, Spriewald, Ullrich, Heidkamp, Dudziak, Nimmerjahn: Fcγ receptor IIB (FcγRIIB) maintains humoral tolerance in the human immune system in vivo. in Proceedings of the National Academy of Sciences of the United States of America 2011 (PubMed)
    Show all 2 references for ABIN1098464

More Proteins for FCGR2B Interaction Partners

Human Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) interaction partners

  1. Fc-gamma receptor (show FCGR1A Proteins) polymorphisms differentially influence susceptibility to systemic lupus erythematosus and lupus nephritis.

  2. LPS (show IRF6 Proteins) activation of TLR4 (show TLR4 Proteins) significantly increased MARCH3 (show MARCH3 Proteins) expression and that siRNA against MARCH3 (show MARCH3 Proteins) prevented the decrease in FcgammaRIIb following LPS (show IRF6 Proteins) treatment.

  3. a rare FCGR2B null-variant allele was found, in which a polymorphic stop codon of FCGR2C is introduced into one FCGR2B gene

  4. FcgammaRIIB requires Btk (show BTK Proteins) and p38 MAPK (show MAPK14 Proteins) to mediate antigen-independent inhibition in human B cells.

  5. The FCGR2B variant leads to reduced serum IL-6 (show IL6 Proteins), later disease onset and reduced need for biological treatment, but does not seem to aggravate RA. The TM region variant is associated with a lower activation state of the Tregs and naive and memory B cells.

  6. FcgIIb on GM-CSF (show CSF2 Proteins) macrophages has a role in controlling immune complex-mediated inhibition of inflammatory signals

  7. none of the three functional polymorphisms in FcgammaR genes explored here, the FCGR3A (show CD16 Proteins) F158V and FCGR2B I232T nsSNPs and the VNTR in FCGRT (show FCGRT Proteins), showed an association with the response to TNFi in patients with rheumatoid arthritis

  8. Data show that the recombinant Fc gamma receptors FcgammaRIa (show FCGR1A Proteins), FcgammaRIIa, FcgammaRIIb, FcgammaRIIIa(Phe158/Val158), and FcgammaRIIIb glycosylation is complex and varied between receptors.

  9. FCGR2B inhibitory gene may be predictive of adjuvant trastuzumab benefit in HER2 (show ERBB2 Proteins)+ breast cancer patients.

  10. Data indicate that Fcgamma receptors FcgammaRIIb and FcgammaRIIa may play a structural role in augmenting CD20 (show MS4A1 Proteins) internalization.

Mouse (Murine) Fc Fragment of IgG, Low Affinity IIb, Receptor (CD32) (FCGR2B) interaction partners

  1. CD32 is a crucial regulator of FVIII (show F8 Proteins)-specific B cells and is required for the differentiation of memory B cells into antibody-secreting cells.

  2. Aggregated alpha-Synuclein (alpha-syn) inhibited microglial phagocytosis. The inhibitory effect of aggregated alpha-syn on microglial phagocytosis was due to the activation of SHP-1 and FcgammaRIIB on microglia.

  3. Fcgr2b(-/-) mice lose bone upon the onset of a hypergammaglobulinemia or the administration of IgG1 immune complexes.

  4. IgG (FcgammaR) IIb is involved in the suppressive effect of immune complex on TLR9 (show TLR9 Proteins)-mediated CD40 (show CD40 Proteins), CD80 (show CD80 Proteins) and IL-6 (show IL6 Proteins) expression.

  5. these studies demonstrate for the first time the ability of FcgammaRIIB to regulate vaccine-induced IgA production and downmodulate immunity and protection.

  6. This inhibitory receptor present on dendritic cells, neutrophils, and B cells has an important role in controlling anti-myeloperoxidase (show MPO Proteins) autoimmunity and limiting pathological effector responses and glomerular disease.

  7. Deletion of FcgammaRIIb/ApoE (show APOE Proteins) induces an anti-inflammatory Treg/macrophage polarization that is atheroprotective.

  8. Fcgamma-RII and Fcgamma-RIII might participate in the uptake and/or transport of IgG through the intestinal epithelia of adult mice.

  9. Aging Siglec-G (show SIGLEC10 Proteins)-deficient and Siglec-G (show SIGLEC10 Proteins) 3/FcgammaRIIb double-deficient mice develop an autoimmune phenotype with elevated autoantibody levels and mild glomerulonephritis.

  10. This study demonstrated that the activating FcgammaRs-mediated inflammation plays a critical role in anti-ganglioside Abs-induced neuropathy (injury to intact nerve fibers) in GBS (show GNB5 Proteins).

FCGR2B Protein Profile

Protein Summary

The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with FCGR2B

  • Fc fragment of IgG, low affinity IIb, receptor (CD32) (FCGR2B)
  • Fc receptor, IgG, low affinity IIb (Fcgr2b)
  • AI528646 protein
  • CD32 protein
  • CD32B protein
  • F630109E10Rik protein
  • FCG2 protein
  • Fcgr2 protein
  • Fcgr2a protein
  • FCGR2B protein
  • FcgRII protein
  • Fcr-2 protein
  • Fcr-3 protein
  • Fc[g]RII protein
  • IGFR2 protein
  • Ly-17 protein
  • Ly-m20 protein
  • Lym-1 protein

Protein level used designations for FCGR2B

CDw32 , Fc fragment of IgG, low affinity II, receptor for (CD32) , Fc fragment of IgG, low affinity IIb, receptor for (CD32) , Fc gamma RIIb , fc-gamma RII-b , fc-gamma-RIIb , fcRII-b , igG Fc receptor II-b , low affinity immunoglobulin gamma Fc region receptor II-b , Fc fragment of IgG, low affinity IIb, receptor (CD32) , Fc fragment of IgG, low affinity IIb, receptor , IgG Fc gamma receptor II , Fc gamma RIIB , Fc-gamma-RII , FcgammaRIIB , fc gamma receptor IIB , fc-gamma RII , fc-gamma-RIIB , fcRII , igG Fc receptor II beta , low affinity immunoglobulin gamma Fc region receptor II , lymphocyte antigen 17

2213 Homo sapiens
746456 Pan troglodytes
100192432 Ovis aries
14130 Mus musculus
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