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Human GSTP1 Protein expressed in Wheat germ - ABIN1306100
Andrukhova, Salama, Krssak, Wiedemann, El-Housseiny, Hacker, Gildehaus, Andrukhov, Mirzaei, Kocher, Zuckermann, Aharinejad: Single-dose GSTP1 prevents infarction-induced heart failure. in Journal of cardiac failure 2014
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polymorphisms of the GSTM1 (show GSTM1 Proteins) del and GSTT1 (show GSTT1 Proteins) del genes were analysed by multiplex PCR. Genotyping of the polymorphic variants in the GSTP1 (A313G, T341C) gene was performed using Real-time PCR with competing TaqMan probes complementary to the polymorphic DNA sites
genetic or pharmacological inactivation of GSTP1 impairs cell survival and tumorigenesis in TNBC cells; GSTP1 inhibitors may be a novel therapeutic strategy for combatting TNBCs through impairing key cancer metabolism and signaling pathways
Wild-type GSTP1 allele when combined with LOH/MSI (show MSI1 Proteins) in steroid metabolism genes may play a role in ER and/or PR negative breast cancers.
meta-analysis suggests that the GSTP1 Ile105Val polymorphism might not contribute to risk of male infertility
there is a significant implication of the SNP rs1695 within the GSTP1 gene with ALL of Jordanian Arab children.
RASSF10 functions as a tumor suppressor by cooperating with GSTP1 to deregulate JNK/c-Jun/AP-1 (show JUN Proteins) pathway in gastric cancer
Autism Spectrum Disorder status may be a potential effect modifier when assessing the association between GSTP1 rs1695 but not (GSTM1 (show GSTM1 Proteins) or GSTT1 (show GSTT1 Proteins)) and blood aluminum concentrations, among Jamaican children.
Combined GSTM1 (show GSTM1 Proteins), GSTT1 (show GSTT1 Proteins), GSTA1 (show GSTA1 Proteins) and GSTP1 polymorphisms might be associated to the risk of clear cell renal cell carcinoma (show MOK Proteins).
GSTP1 gene polymorphisms were not associated with the acquisition of hepatotoxicity in HIV patients treated with antiretroviral therapy.
Individuals carrying theGSTP1 Ile-Ile or XRCC1399 Arg-Arg genotypes showed greater DNA damage than observed for other alleles.
GSTP can exert redox regulation in the oxidative ER environment and indicate that, within the ER, GSTP influences the cellular consequences of the UPR through S-glutathionylation of a series of key interrelated proteins. Antioxid.
our study reveals the novel role of GSTP1 in regulation of iNOS (show NOS2 Proteins) by affecting S-nitrosylation, dimerization, and stability.
These observed differences contribute to our understanding of how genetic ablation of GSTP causes different levels of myeloproliferation and migration [corrected]
GSTP1/2 are a critical regulators of hepatocyte proliferation in the initial phases of liver regeneration.
GSTP1 expression in retina increases with developmental age in mice and accompanies murine retinal maturation.
GSTP knock-out mice display decreased ubiquitination capacity and overall increased susceptibility to oxidative stress.
Report increased GSTP1 in airways of asthmatic mice.
DNIC storage function of GST P1-1 and ability of MRP1 (show ABCC1 Proteins) to efflux DNICs are vital in protection against NO cytotoxicity
Gst-pi expression of the prostate cancers are dependent on metastatic site.
GSTP plays a major role in carcinogenesis distinct from its role in detoxification and provides evidence that the enzyme is a key determinant of the proinflammatory tumor environment.
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
, deafness, X-linked 7
, fatty acid ethyl ester synthase III
, glutathione S-transferase P
, GST 7-7
, Glutathione-S-transferase placental enzyme pi type
, Glutathione-S-transferase, placental enzyme pi type
, chain 7
, glutathione S-transferase pi 2
, glutathione S-transferase, pi 2
, glutathione-S-transferase, pi 1
, Glutathione S-transferase P
, GST-pi enzyme
, glutathione S-transferase P 1
, GST YF-YF
, Gst p-1
, gst P1
, preadipocyte growth factor