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Human GSTP1 Protein expressed in Wheat germ - ABIN1306100
Andrukhova, Salama, Krssak, Wiedemann, El-Housseiny, Hacker, Gildehaus, Andrukhov, Mirzaei, Kocher, Zuckermann, Aharinejad: Single-dose GSTP1 prevents infarction-induced heart failure. in Journal of cardiac failure 2014
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These observations could support the hypothesis that the GSTP1 G allele may improve exercise performance by better elimination of exercise-induced reactive oxygen species.
This study demonstrates that the GSTP1*B and *C allelic variants may be considered a candidate gene for AD[Alzheimer disease]. It can be suggested that although CYP2D6*4 polymorphism is not a risk of AD[Alzheimer disease], the CYP2D6*4 and GSTP1 polymorphism may interact with beta-HCH, dieldrin, and copper to influence the risk of AD [Alzheimer disease].
Comparing to controls, significant association with asthma was observed for GSTP1 rs1695 AA genotype
Peroxidase activity was markedly reduced by mutation at either of the Leu sites and was essentially abolished by the double mutation, while PLA2 (show YWHAZ Proteins) activity was unaffected. Decreased peroxidase activity following mutation of the interfacial leucines presumably is mediated via impaired heterodimerization of Prdx6 (show PRDX6 Proteins) with piGST that is required for reduction and re-activation of the oxidized enzyme.
Epigenetic alteration of GSTP1 regulates its expression in lens epithelial and cortical tissues. These changes likely contribute to the pathogenesis of ARNC.
GSTP1 rs1695 polymorphism was associated with higher susceptibility to the development of cervical lesions in HR-HPV-infected women.
Single nucleotide polymorphisms in EPHX1, GSTP1, SERPINE2, and TGFB1 contributing to the quantitative traits of chronic obstructive pulmonary disease in Chinese Han population.
polymorphisms of the GSTM1 (show GSTM1 Proteins) del and GSTT1 (show GSTT1 Proteins) del genes were analysed by multiplex PCR. Genotyping of the polymorphic variants in the GSTP1 (A313G, T341C) gene was performed using Real-time PCR with competing TaqMan probes complementary to the polymorphic DNA sites
genetic or pharmacological inactivation of GSTP1 impairs cell survival and tumorigenesis in TNBC cells; GSTP1 inhibitors may be a novel therapeutic strategy for combatting TNBCs through impairing key cancer metabolism and signaling pathways
Wild-type GSTP1 allele when combined with LOH/MSI (show MSI1 Proteins) in steroid metabolism genes may play a role in ER and/or PR negative breast cancers.
Expression of both wild-type and catalytically-inactive Y7F mutant GSTP significantly attenuated LPS (show TLR4 Proteins)- or IKKbeta (show IKBKB Proteins)-induced production of GM-CSF (show CSF2 Proteins). These studies indicate a complex role for GSTP in modulating NF-kappaB (show NFKB1 Proteins), which may involve S-glutathionylation of IKK (show CHUK Proteins) proteins, and interaction with NF-kappaB (show NFKB1 Proteins) family members.
GSTP can exert redox regulation in the oxidative ER environment and indicate that, within the ER, GSTP influences the cellular consequences of the UPR through S-glutathionylation of a series of key interrelated proteins. Antioxid.
our study reveals the novel role of GSTP1 in regulation of iNOS (show NOS2 Proteins) by affecting S-nitrosylation, dimerization, and stability.
These observed differences contribute to our understanding of how genetic ablation of GSTP causes different levels of myeloproliferation and migration [corrected]
GSTP1/2 are a critical regulators of hepatocyte proliferation in the initial phases of liver regeneration.
GSTP1 expression in retina increases with developmental age in mice and accompanies murine retinal maturation.
GSTP knock-out mice display decreased ubiquitination capacity and overall increased susceptibility to oxidative stress.
Report increased GSTP1 in airways of asthmatic mice.
DNIC storage function of GST P1-1 and ability of MRP1 (show ABCC1 Proteins) to efflux DNICs are vital in protection against NO cytotoxicity
Gst-pi expression of the prostate cancers are dependent on metastatic site.
Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
, deafness, X-linked 7
, fatty acid ethyl ester synthase III
, glutathione S-transferase P
, GST 7-7
, Glutathione-S-transferase placental enzyme pi type
, Glutathione-S-transferase, placental enzyme pi type
, chain 7
, glutathione S-transferase pi 2
, glutathione S-transferase, pi 2
, glutathione-S-transferase, pi 1
, Glutathione S-transferase P
, GST-pi enzyme
, glutathione S-transferase P 1
, GST YF-YF
, Gst p-1
, gst P1
, preadipocyte growth factor