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Human Polyclonal IL24 Primary Antibody for CyTOF, FACS - ABIN4900398
Tahara, Miyake, Hanawa, Kurai, Hirai, Ishizaki, Uchida, Tajiri, Shimada: Systemic cancer gene therapy using adeno-associated virus type 1 vector expressing MDA-7/IL24. in Molecular therapy : the journal of the American Society of Gene Therapy 2007
Show all 3 Pubmed References
this paper shows that IL-24 represents a potential biomarker of allergic inflammation and a Th2 polarized condition of the epithelium
Low IL24 expression is associated with endometriosis.
IL-20 (show IL20 Antibodies) and IL-24 increased the production of monocyte chemoattractant protein-1 (show CCL2 Antibodies) by activated spondyloarthritis synovial fluid monocytes, decreased the production of Dickkopf-1 (show DKK1 Antibodies) by SpA (show FASL Antibodies) fibroblast-like synovial cells and induced mineralization in human osteoblasts; taken together, findings indicate disease-aggravating functions of IL-20 (show IL20 Antibodies) and IL-24 in spondyloarthritis
a novel pathway for mda-7/IL-24-induced caspase (show CASP3 Antibodies)-independent apoptosis in neuroblastoma (show ARHGEF16 Antibodies) cells mediated through modulation of AIF (show AIFM1 Antibodies), ATM (show ATM Antibodies), and gamma-H2AX (show H2AFX Antibodies).
mda-7/IL-24 directly regulates miRNA expression in cancer cells and highlights the novelty of the mda-7/IL-24-miR (show MLXIP Antibodies)-221-beclin-1 (show BECN1 Antibodies) loop in mediating cancer cell-specific death.
LINC00152-mediated oncogenic effects occur in part through the epigenetic silencing of IL24 expression following binding with EZH2 (show EZH2 Antibodies).
mechanistic studies, inhibition of SRC (show SRC Antibodies) and PKCdelta (show PKCd Antibodies) completely ablated the ability of MDA-7/IL-24 to reduce the Bcl-x(L (show BCL2L1 Antibodies))/(s) mRNA ratio and cell viability. These findings show that Bcl-x (show BCL2L1 Antibodies)(s) expression is an important mediator of MDA-7/IL-24-induced cytotoxicity requiring the SRC (show SRC Antibodies)/PKCdelta (show PKCd Antibodies) signaling axis in NSCLC cells.
Expression of IL-24 and IGFBP-3 (show IGFBP3 Antibodies) significantly suppressed prostate cancer tumor growth in vivo.
Results suggest that IL-24 exerts a potent suppressive effect on influenza viral replication and can be used in the treatment of influenza infection.
Expression of IL-24 enhanced the sensitivity of B lymphoma cells to chemotherapy agents by altering the expression of multidrug-resistance genes via downregulating GTP (show AK3 Antibodies)-RhoA (show RHOA Antibodies)-ERK (show EPHB2 Antibodies) signaling pathway
our data suggest that IL-20 (show IL20 Antibodies) subfamily cytokines, particularly IL-20 (show IL20 Antibodies), IL-22 (show IL22 Antibodies), and IL-24, might provide therapeutic benefit for patients with Diabetic foot ulcers (DFU) .
this study shows that IL-24 promotes Pseudomonas aeruginosa keratitis through the suppression of early protective mucosal immunity
Loss of IL-24 expression is associated with breast cancer.
A psoriasis-like skin inflammation in mice with epidermis-specific inhibition of NF-kappaB (show NFKB1 Antibodies) was triggered by TNFR1 (show TNFRSF1A Antibodies)-dependent upregulation of interleukin-24 & activation of STAT3 (show STAT3 Antibodies) signaling in keratinocytes.
IL-24 suppresses the growth of normal vascular smooth muscle cells by inhibiting hydrogen peroxide-induced reactive oxygen species (ROS (show ROS1 Antibodies)) production through the regulation of mitochondrial ROS (show ROS1 Antibodies) production and expression of antioxidant enzymes
Secretory mIL-24 did not induce the expression of the IL-6 (show IL6 Antibodies), TNF-alpha (show TNF Antibodies) or IFN-gamma (show IFNG Antibodies) gene in spleen cells
T cell receptor stimulation induces IL-24 expression in T helper type (Th)2 cells by the coordinate action of Stat6 (show STAT6 Antibodies) and c-Jun (show JUN Antibodies) transcription factors at the transcriptional level.
induction of Il24 by oncogenes may support tumor growth at the early stages of cancer
Grp170 (show HYOU1 Antibodies) enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
IL-4-induced secreted protein
, melanocyte-associated Mda-7
, melanoma differentiation-associated gene 7 protein
, suppression of tumorigenicity 16 (melanoma differentiation)
, th2-specific cytokine FISP
, cytokine-like protein Mob-5
, interleukin 24