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Human LCN2 Protein expressed in - ABIN621226
Wang, Liu, Meng, Liu, Wang, Li, Cui, Meng, Hu, Wei: Up-regulated lipocalin-2 in pulmonary hypertension involving in pulmonary artery SMC resistance to apoptosis. in International journal of biological sciences 2014
Lipocalin-2 Promotes Endoplasmic Reticulum Stress and Proliferation by Augmenting Intracellular Iron in Human Pulmonary Arterial Smooth Muscle Cells
Acute kidney injury is more common with sepsis than non-infectious systemic inflammatory response syndrome. Plasma NGAL was diagnostic of AKI in both subgroups.
This study tested the utility of neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (CysC (show CST3 Proteins)) in addition to standard creatinine for early determination of Acute Kidney Injury (AKI) After Heart Operations Using Cardiopulmonary Bypass. The results support the notion that CysC (show CST3 Proteins) and NGAL should be viewed as comparable for early AKI detection.
Data suggest that elevated serum LCN2 level in overweight/obese women may serve as biomarker for risk of developing metabolic syndrome (MetS); serum NGAL levels positively correlated with saturated fatty acid dietary intake; serum NGAL increased proportionally with increase in MetS risk factors. This study was conducted in the Republic of Korea.
The role of LCN2 in Iron Homeostasis and Inflammation is reviewed.
The results indicate that urine levels of NGAL and retinol binding protein may be independently associated with albuminuria in the diagnosis of type 2 diabetic nephropathy and may serve as novel biomarkers for the identification of type 2 diabetic nephropathy.
clinical significance of serum levels of neutrophil gelatinase-associated lipocalin (sNGAL) as a biomarker for predicting in-hospital outcomes in patients with ST-elevated myocardial infarction (STEMI)
Serum and urinary NGAL were higher in the critically ill group that developed acute kidney injury compared to critically ill patients without AKI.
LCN-2 expression and serum levels could discriminate IGT from NGT and type 2 diabetes mellitus (T2DM)from IGT obese women and early predicting T2DM among obese women. While, LCN-2 expression level was the independent predictor of IGT in obese women. Combination of both LCN-2 expression and serum levels improved their diagnostic value in early detection of IGT and T2DM among obese women
LCN2 modulated the secretion of proinflammatory cytokines in PSC of the PDAC tumor microenvironment, whereas downregulation of LCN2-specific receptor SLC22A17 (show SLC22A17 Proteins) blocked these effects. Our results reveal how LCN2 acts in the tumor microenvironment links obesity, inflammation, and PDAC development.
Overexpression of exogenous kidney-specific Ngal reduced cystic progression and prolonged the lifespan in polycystic kidney disease mice, and was associated with reductions in interstitial fibrosis and proliferation, and augmented apoptosis.
Either Lcn2 deficiency or anti-Lcn2 antibody blockade limits abdominal aortic aneurysm expansion in mice by decreasing neutrophil infiltration in the aorta.
Results suggest that blood brain barrier leakage occurs in white matter after subarachnoid hemorrhage (SAH (show ACSM3 Proteins)) and that LCN2 contributes to SAH (show ACSM3 Proteins)-induced blood brain barrier disruption.
LCN2 overexpression in bones modifies the bone marrow microenvironment via modulation of the expression of key secreted factors and cytokines, which in turn regulate the hematopoietic stem cell niche behavior enhancing both HSC (show FUT1 Proteins) homing in young mice and erythrocytes production in older mice.
results identify lipocalin 2 as a bone-derived hormone with metabolic regulatory effects, which suppresses appetite in a MC4R (show MC4R Proteins)-dependent manner, and show that the control of appetite is an endocrine function of bone
Lcn2 can suppress the beneficial cardiac autophagic response to ischemia and that this contributes to enhanced ischemia-induced cell death and cardiac dysfunction.
Plasma levels of LCN2 measured in patients one week after ischemic stroke contribute to the prediction of clinical outcome at 90 days and reflect the systemic response to post-stroke infections
may potentiate the development of psoriasis via the enhancement of Th17- and antimicrobial peptide (show cAMP Proteins)-mediated inflammation
The acute stress protein LCN2, produced from RPE (show RPE Proteins) cells and the neural retina, could modulate retinal inflammation and retinal homeostasis; therefore, such families of proteins could contribute to cell survival during retinal insults.
we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9 (show MMP9 Proteins), TIMP1 (show TIMP1 Proteins), and NGAL (also MMP2 (show MMP2 Proteins) in 220 kDa complex) without proteolytic activity.
porcine p25alpha (show Tppp Proteins) is heavily modified with a variety of modifications: phosphorylation, di- and trimethylation, citrullination and a HexNAc group.
mouse homolog plays a role in IL3 withdrawal-induced apoptosis
, lipocalin 2 (oncogene 24p3)
, 25 kDa alpha-2-microglobulin-related subunit of MMP-9
, migration-stimulating factor inhibitor
, neutrophil gelatinase-associated lipocalin
, oncogene 24p3
, siderocalin LCN2
, SV-40-induced 24P3 protein
, secreted inducible protein 24
, alpha-2-microglobulin-related protein
, alpha-2U globulin-related protein