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This study suggests that P2Y2 may participate in cardiomyopathy in mdx (show DMD ELISA Kits) mice.
Extracellular ATP induces vascular inflammation and atherosclerosis via activation of P2Y2.
Endothelial cell-specific P2Y2R deficiency reduces atherosclerotic burden and promotes plaque stability in ApoE (show APOE ELISA Kits)(-/-) mice through impaired macrophage infiltration acting together with reduced matrix metalloproteinase-2 (show MMP2 ELISA Kits) activity and increased smooth muscle cell migration.
expression of P2Y (show P2RY1 ELISA Kits)(2) receptor in peripheral sensory neurons that innervate the injured tissue and the activation of P2Y (show P2RY1 ELISA Kits) receptors contributes to mechanical allodynia following inflammation
In P2Y1R (-/-) mice, the expression of P2Y2 receptor in muscle was reduced by over 50 %, as compared to P2Y1R (+/+) mice.
P2Y2R deficiency does not alter baseline collateral vessel formation but does significantly impair collateral maturation, with resultant persistent limb ischemia despite enhanced angiogenesis.
P2Y2-/- mice are less susceptible to mount an autoimmune response against IRBP (show RBP3 ELISA Kits)
P2Y2 and Gq/G11 (show STK19 ELISA Kits) are required for basal endothelial NO formation, vascular tone, and blood pressure.
The data suggest that the P2Y2/4 receptor activation elicits blood pressure responses via distinct mechanisms involving KCa3.1 (show KCNN4 ELISA Kits) and Cx37 (show GJA4 ELISA Kits).
P2Y2-mediated increase of cytoplasmic Ca(2 (show CA2 ELISA Kits)+) concentration down-regulates the expression of NCC (show SLC12A3 ELISA Kits).
There is increased expression of P2Y2 receptors in the rectosigmoid mucosa of diarrhea-predominant irritable bowel syndrome patients. P2Y2 correlated with abdominal pain.
A novel SNP-systemic lupus erythematosus association was identified between FCHSD2 and P2RY2, peaking at rs11235667 on a 33-kb haplotype upstream of ATG16L2.
Hypoxia and upregulated HIF-1a (show HIF1A ELISA Kits) both upregulated the P2Y2 levels in hepatocellular carcinoma cells and increased their survival.
Results show that purinergic receptor P2Y2 (P2Y2R) requires N-glycosylation for expression on the cell surface.
Data indicate that knockdown of caveolin-1 (Cav-1 (show CAV1 ELISA Kits)) expression causes redistribution of the P2Y2 nucleotide receptor (P2Y2R) from membrane rafts.
The P2RY2 receptor induces carcinoma cell migration and epithelial-mesenchymal transition through cross-talk with EGFR (show EGFR ELISA Kits).
Activation of P2Y2R increased TF promoter activity and mRNA expression in coronary artery endothelial cells.
Data show that the purinergic receptor P2Y2 (P2Y2R) pepducin activates neutrophils through formyl peptide receptor 2 (FPR2 (show FPR2 ELISA Kits)), and ATP is turned into an activating agonist through a receptor cross-talk mechanism that involves both FPR2 (show FPR2 ELISA Kits) and P2Y2R.
P2Y2 receptor and EGFR (show EGFR ELISA Kits) cooperate to promote prostate cancer cell invasion via ERK1/2 (show MAPK1/3 ELISA Kits) pathway.
These results indicate that B2R couples with P2Y2R and that these G-protein-coupled receptors act together to fine-tune cellular responsiveness.
the effect of ATP on Na+-ATPase (show DNAH8 ELISA Kits) activity could be involved in antinatriuresis induced by P2Y4 receptor (show P2RY4 ELISA Kits) or a mechanism to counterbalance the natriuretic effect of P2Y2 receptor, promoting fine control of sodium reabsorption in proximal tubule cells.
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene.
P2Y purinoceptor 2
, ATP receptor
, P2U purinoceptor 1
, P2U nucleotide receptor
, P2U receptor 1
, purinergic receptor P2Y2
, purinoceptor P2Y2
, P2Y ATP receptor 2
, P2Y2 nucleotide receptor