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anti-Human SCARB1 Antibodies:
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Human Polyclonal SCARB1 Primary Antibody for BP, FACS - ABIN152890
Wüstner, Mondal, Huang, Maxfield: Different transport routes for high density lipoprotein and its associated free sterol in polarized hepatic cells. in Journal of lipid research 2004
Show all 24 Pubmed References
Chinese Hamster Polyclonal SCARB1 Primary Antibody for BP, FACS - ABIN152880
Huang, Mazzone: ApoE-dependent sterol efflux from macrophages is modulated by scavenger receptor class B type I expression. in Journal of lipid research 2002
Show all 81 Pubmed References
Chinese Hamster Polyclonal SCARB1 Primary Antibody for FACS, ICC - ABIN152882
Brodeur, Luangrath, Bourret, Falstrault, Brissette: Physiological importance of SR-BI in the in vivo metabolism of human HDL and LDL in male and female mice. in Journal of lipid research 2005
Show all 146 Pubmed References
Hamster Polyclonal SCARB1 Primary Antibody for FACS, ICC - ABIN152899
Bocharov, Baranova, Vishnyakova, Remaley, Csako, Thomas, Patterson, Eggerman et al.: Targeting of scavenger receptor class B type I by synthetic amphipathic alpha-helical-containing peptides blocks lipopolysaccharide (LPS) uptake and LPS-induced pro-inflammatory cytokine responses in ... in The Journal of biological chemistry 2004
Show all 16 Pubmed References
Human Polyclonal SCARB1 Primary Antibody for FACS, ICC - ABIN152901
Harder, Meng, Rippstein, McBride, McPherson: SR-BI undergoes cholesterol-stimulated transcytosis to the bile canaliculus in polarized WIF-B cells. in The Journal of biological chemistry 2007
Show all 7 Pubmed References
Human Polyclonal SCARB1 Primary Antibody for WB - ABIN1881777
Kolmakova, Wang, Brogan, Chaffin, Rodriguez: Deficiency of scavenger receptor class B type I negatively affects progesterone secretion in human granulosa cells. in Endocrinology 2010
Show all 5 Pubmed References
Chinese Hamster Polyclonal SCARB1 Primary Antibody for IHC (fro), IHC (p) - ABIN268843
Hullinger, Panek, Xu, Karathanasis: p21-activated kinase-1 (PAK1) inhibition of the human scavenger receptor class B, type I promoter in macrophages is independent of PAK1 kinase activity, but requires the GTPase-binding domain. in The Journal of biological chemistry 2001
Show all 5 Pubmed References
Human Monoclonal SCARB1 Primary Antibody for IF, WB - ABIN968230
Acton, Rigotti, Landschulz, Xu, Hobbs, Krieger: Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. in Science (New York, N.Y.) 1996
Show all 4 Pubmed References
Human Monoclonal SCARB1 Primary Antibody for IF, WB - ABIN968231
Calvo, Vega: Identification, primary structure, and distribution of CLA-1, a novel member of the CD36/LIMPII gene family. in The Journal of biological chemistry 1993
Show all 4 Pubmed References
Chicken Polyclonal SCARB1 Primary Antibody for FACS, IF (p) - ABIN738936
Gabriel, Becher-Deichsel, Hlavaty, Mair, Walter: The physiological expression of scavenger receptor SR-B1 in canine endometrial and placental epithelial cells and its potential involvement in pathogenesis of pyometra. in Theriogenology 2016
Show all 2 Pubmed References
SCARB1 gene variants are associated with a new lipid phenotype, characterized by high levels of both HDL (show HSD11B1 Antibodies) cholesterol and Lp(a (show APOA Antibodies)). SCARB1 exonic variants often result in diminished function of translated SR-B1 via reduced binding/intracellular transport of Lp(a (show APOA Antibodies)).
Data suggest that activation of SR-BI by APOAI down-regulates sphingosine 1-phosphate/S1PR2 (show S1PR2 Antibodies)-mediated inflammation in vascular endothelial cells by activating the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling pathway; oxidized-LDL does the opposite. (APOA1 (show APOA1 Antibodies) = apolipoprotein A-I (show APOA1 Antibodies); SR-BI/SCARB1 = scavenger receptor class B type I; S1PR2 (show S1PR2 Antibodies) = sphingosine 1-phosphate receptor 2 (show S1PR2 Antibodies); PI3K (show PIK3CA Antibodies) = phosphatidylinositol 3-kinase; Akt (show AKT1 Antibodies) = proto-oncogene c-akt (show AKT1 Antibodies))
Sustained virologic response was significantly associated with SCARB1 rs10846744 in chronic hepatitis C patients, treated with pegylated interferon-alpha (show IFNA Antibodies) and ribavirin.
Model recombinant HDL (show HSD11B1 Antibodies) (rHDL) particles formed in vitro with S1P (show MBTPS1 Antibodies) incorporated into the particle initiated the internalization of S1PR1 (show S1PR1 Antibodies), whereas rHDL without supplemented S1P (show MBTPS1 Antibodies) did not, suggesting that S1P (show MBTPS1 Antibodies) transported in HDL (show HSD11B1 Antibodies) can selectively activate S1PR1 (show S1PR1 Antibodies).
Data implicate that scavenger receptor class B member 1 (SR-B1) as a target in chronic lymphocytic leukemia (CLL) and high-density lipoproteins nanoparticles (HDL (show HSD11B1 Antibodies) NPs (show NPS Antibodies)) as targeted monotherapy for CLL.
SCARB1 gene polymorphisms may contribute to genetic susceptibility to coronary heart disease. C allele of rs10846744 and the C allele of rs2278986 may serve as risk and protective factors for CHD (show CHDH Antibodies), respectively.
VEGF-A (show VEGFA Antibodies) was found to be a prerequisite for the localization of scavenger receptor BI in the plasma membrane of endothelial cells and is a regulatory factor of transendothelial transport of HDL (show HSD11B1 Antibodies) but not LDL.
our findings implied that scavenger receptor class B type 1 might serve as a diagnostic and independent prognostic biomarker in clear cell renal cell carcinoma (show MOK Antibodies).
data support an SR-B1 nibbling mechanism that is similar to that of streptococcal serum opacity factor, which also selectively removes CE and releases apoAI, leaving an apoAII (show APOA2 Antibodies)-rich remnant.
Using mass spectrometry and site directed mutagenesis, a new Sp1 (show PSG1 Antibodies) phosphorylation site Ser702 was defined to be associated with Sp1 (show PSG1 Antibodies)-HDAC1 (show HDAC1 Antibodies) interaction and may be important in SR-BI activation, shedding light on the knowledge of delicate mechanism of hepatic HDL (show HSD11B1 Antibodies) receptor SR-BI gene modulation by LDL.
Our results suggest that LPA-enhanced foam cell formation is mediated by LPA1 (show LPAR1 Antibodies)/3 -AKT (show AKT1 Antibodies) activation and subsequent SRBI expression.
Results show the first high-resolution structure of the C-terminal transmembrane domain of SR-BI. This region of SR-BI harbors a leucine zipper dimerization motif, which when mutated impairs the ability of the receptor to bind HDL (show HSD11B1 Antibodies) and mediate cholesterol delivery.
Carboxy-terminal deletion of SR-BI reduced receptor levels in liver and steroidogenic tissues (adrenal cortex, ovary, testicular Leydig cells) and induced hypercholesterolemia.
Loss of ScarB1 is associated with Coronary Atherosclerosis and Ischemic Heart Disease in Low-density Lipoprotein Receptor (show LDLR Antibodies) Knockout Mice when fed the modified western-type diet.
We showed here that SR-BI deficiency led to increased atherogenesis with features of advanced fibroatheroma and expansive arterial remodeling in LDL-R KO mice fed an atherogenic diet.
The seven intron CGIs are methylated differentially in Y1 cells, mouse Leydig tumor cells, ovarian granulosa cells, and mouse liver hepa 1-6 cells; experiments raised the possibility that DNA methylation (show HELLS Antibodies) participates in hormonal regulation of SR-BI expression in a tissue-specific manner.
SR-B1, the HDL (show HSD11B1 Antibodies) receptor, is expressed abundantly in liver sinusoidal endothelial cells and marginally in hepatocytes.
SR-B1 and targeted HDL (show HSD11B1 Antibodies) NPs (show NPS Antibodies) provide a fundamental advance in studying cholesterol-dependent cellular uptake mechanisms.
Studied the role of SR-BI in endothelial cells using several novel transgenic mouse models expressing SR-BI in endothelium of mice with normal C57Bl6/N, apoE (show APOE Antibodies)-KO, or Scarb1-KO backgrounds.
Luteinization causes upregulation of SR-BI expression, its posttranslational maturation by glycosylation, and insertion into luteal cell membranes.
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI or ABCG1 (show ABCG1 Antibodies) but not ABCA1 (show ABCA1 Antibodies).
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.
scavenger receptor class B member 1
, scavenger receptor class B, member 1
, scavenger receptor class B type I
, high density lipoprotein receptor SR-BI
, CD36 and LIMPII analogous 1
, CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
, scavenger receptor class B type III
, HDL QTL 1
, scavenger receptor class B1
, CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1)
, scavanger receptor class B type 1
, CD36 antigen (collagen type I receptor, thrombospondin receptor-like 1)