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anti-Human SCARB1 Antibodies:
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Chinese Hamster Polyclonal SCARB1 Primary Antibody for FACS, ICC - ABIN152882
Brodeur, Luangrath, Bourret, Falstrault, Brissette: Physiological importance of SR-BI in the in vivo metabolism of human HDL and LDL in male and female mice. in Journal of lipid research 2005
Show all 146 Pubmed References
Chinese Hamster Polyclonal SCARB1 Primary Antibody for BP, FACS - ABIN152880
Huang, Mazzone: ApoE-dependent sterol efflux from macrophages is modulated by scavenger receptor class B type I expression. in Journal of lipid research 2002
Show all 81 Pubmed References
Human Polyclonal SCARB1 Primary Antibody for BP, FACS - ABIN152890
Wüstner, Mondal, Huang, Maxfield: Different transport routes for high density lipoprotein and its associated free sterol in polarized hepatic cells. in Journal of lipid research 2004
Show all 24 Pubmed References
Hamster Polyclonal SCARB1 Primary Antibody for FACS, ICC - ABIN152899
Bocharov, Baranova, Vishnyakova, Remaley, Csako, Thomas, Patterson, Eggerman et al.: Targeting of scavenger receptor class B type I by synthetic amphipathic alpha-helical-containing peptides blocks lipopolysaccharide (LPS) uptake and LPS-induced pro-inflammatory cytokine responses in ... in The Journal of biological chemistry 2004
Show all 16 Pubmed References
Human Polyclonal SCARB1 Primary Antibody for FACS, ICC - ABIN152901
Harder, Meng, Rippstein, McBride, McPherson: SR-BI undergoes cholesterol-stimulated transcytosis to the bile canaliculus in polarized WIF-B cells. in The Journal of biological chemistry 2007
Show all 7 Pubmed References
Human Polyclonal SCARB1 Primary Antibody for WB - ABIN1881777
Kolmakova, Wang, Brogan, Chaffin, Rodriguez: Deficiency of scavenger receptor class B type I negatively affects progesterone secretion in human granulosa cells. in Endocrinology 2010
Show all 5 Pubmed References
Human Monoclonal SCARB1 Primary Antibody for IF, WB - ABIN968230
Acton, Rigotti, Landschulz, Xu, Hobbs, Krieger: Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. in Science (New York, N.Y.) 1996
Show all 4 Pubmed References
Human Monoclonal SCARB1 Primary Antibody for IF, WB - ABIN968231
Calvo, Vega: Identification, primary structure, and distribution of CLA-1, a novel member of the CD36/LIMPII gene family. in The Journal of biological chemistry 1993
Show all 4 Pubmed References
Chinese Hamster Polyclonal SCARB1 Primary Antibody for IHC (fro), IHC (p) - ABIN268843
Hullinger, Panek, Xu, Karathanasis: p21-activated kinase-1 (PAK1) inhibition of the human scavenger receptor class B, type I promoter in macrophages is independent of PAK1 kinase activity, but requires the GTPase-binding domain. in The Journal of biological chemistry 2001
Show all 5 Pubmed References
Chicken Polyclonal SCARB1 Primary Antibody for FACS, IF (p) - ABIN738936
Gabriel, Becher-Deichsel, Hlavaty, Mair, Walter: The physiological expression of scavenger receptor SR-B1 in canine endometrial and placental epithelial cells and its potential involvement in pathogenesis of pyometra. in Theriogenology 2016
Show all 2 Pubmed References
Liposomes modified with both apolipoproteins A-I and E were internalized in HepG2 cells in FBS (show FBXO8 Antibodies)-depleted culture medium at the same levels as unmodified liposomes in FBS (show FBXO8 Antibodies)-containing culture medium, which indicates that apolipoproteins A-I and E were the major serum components involved in liposomal binding to SR-B1 or LDLR (show LDLR Antibodies) (or both).
Here we show that inhibition of SR-B1 reduced cell survival, migration and invasion, and cholesterol content in NB cell lines. Additionally analysis of SR-B1 levels in NB patient biopsies using the R2: Genomics Analysis and Visualization Platform showed that high SR-B1 expression correlated with decreased overall and event-free survival.
the cigarette smoke (CS)-induced loss of SRB1 induced an alteration of sebocytes lipid content, also demonstrated by cholesterol quantification in SRB1 siRNA experiments. In conclusion, exposure to CS, induced SRB1 post-translational modifications in sebocytes and this might affect sebocytes/skin functionality
Low SRB1 expression is associated with non-alcoholic steatohepatitis but is unchanged in hepatocellular carcinoma.
SCARB1 rs5888 and environmental oxidative stress have a prominent role in age-related macular degeneration(ARMD) susceptibility, early ARMD progression to advanced stage disease and even in the outcome of the disease-an area of macular lesion.
SCARB1 gene variants are associated with a new lipid phenotype, characterized by high levels of both HDL (show HSD11B1 Antibodies) cholesterol and Lp(a (show APOA Antibodies)). SCARB1 exonic variants often result in diminished function of translated SR-B1 via reduced binding/intracellular transport of Lp(a (show APOA Antibodies)).
Data suggest that activation of SR-BI by APOAI down-regulates sphingosine 1-phosphate/S1PR2 (show S1PR2 Antibodies)-mediated inflammation in vascular endothelial cells by activating the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling pathway; oxidized-LDL does the opposite. (APOA1 (show APOA1 Antibodies) = apolipoprotein A-I (show APOA1 Antibodies); SR-BI/SCARB1 = scavenger receptor class B type I; S1PR2 (show S1PR2 Antibodies) = sphingosine 1-phosphate receptor 2 (show S1PR2 Antibodies); PI3K (show PIK3CA Antibodies) = phosphatidylinositol 3-kinase; Akt (show AKT1 Antibodies) = proto-oncogene c-akt (show AKT1 Antibodies))
Sustained virologic response was significantly associated with SCARB1 rs10846744 in chronic hepatitis C patients, treated with pegylated interferon-alpha (show IFNA Antibodies) and ribavirin.
Model recombinant HDL (show HSD11B1 Antibodies) (rHDL) particles formed in vitro with S1P (show MBTPS1 Antibodies) incorporated into the particle initiated the internalization of S1PR1 (show S1PR1 Antibodies), whereas rHDL without supplemented S1P (show MBTPS1 Antibodies) did not, suggesting that S1P (show MBTPS1 Antibodies) transported in HDL (show HSD11B1 Antibodies) can selectively activate S1PR1 (show S1PR1 Antibodies).
Data implicate that scavenger receptor class B member 1 (SR-B1) as a target in chronic lymphocytic leukemia (CLL) and high-density lipoproteins nanoparticles (HDL (show HSD11B1 Antibodies) NPs (show NPS Antibodies)) as targeted monotherapy for CLL.
To investigate the pharmacokinetics (PKs) and pharmacodynamics (PDs (show SLC26A4 Antibodies)) for ION-353382, an antisense oligonucleotide (ASO) targeting scavenger receptor class B type I (SRB1) mRNA, using alpha-2-macroglobulin (A2M (show A2M Antibodies)), murinoglobulin double-knockout (DKO), and wild-type mice
Rutaecarpine was identified to be a candidate that protected ApoE (show APOE Antibodies)(-/-) mice from developing atherosclerosis through preferentially promoting activities of ABCA1 (show ABCA1 Antibodies) and SR-BI within RCT (show FOXE3 Antibodies).
SR-B1 is a silica receptor associated with canonical inflammasome activation.
Our results suggest that LPA-enhanced foam cell formation is mediated by LPA1 (show LPAR1 Antibodies)/3 -AKT (show AKT1 Antibodies) activation and subsequent SRBI expression.
Results show the first high-resolution structure of the C-terminal transmembrane domain of SR-BI. This region of SR-BI harbors a leucine zipper dimerization motif, which when mutated impairs the ability of the receptor to bind HDL (show HSD11B1 Antibodies) and mediate cholesterol delivery.
Carboxy-terminal deletion of SR-BI reduced receptor levels in liver and steroidogenic tissues (adrenal cortex, ovary, testicular Leydig cells) and induced hypercholesterolemia.
Loss of ScarB1 is associated with Coronary Atherosclerosis and Ischemic Heart Disease in Low-density Lipoprotein Receptor (show LDLR Antibodies) Knockout Mice when fed the modified western-type diet.
We showed here that SR-BI deficiency led to increased atherogenesis with features of advanced fibroatheroma and expansive arterial remodeling in LDL-R KO mice fed an atherogenic diet.
The seven intron CGIs are methylated differentially in Y1 cells, mouse Leydig tumor cells, ovarian granulosa cells, and mouse liver hepa 1-6 cells; experiments raised the possibility that DNA methylation (show HELLS Antibodies) participates in hormonal regulation of SR-BI expression in a tissue-specific manner.
Luteinization causes upregulation of SR-BI expression, its posttranslational maturation by glycosylation, and insertion into luteal cell membranes.
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI or ABCG1 (show ABCG1 Antibodies) but not ABCA1 (show ABCA1 Antibodies).
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.
scavenger receptor class B member 1
, scavenger receptor class B, member 1
, scavenger receptor class B type I
, high density lipoprotein receptor SR-BI
, CD36 and LIMPII analogous 1
, CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
, scavenger receptor class B type III
, HDL QTL 1
, scavenger receptor class B1
, CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1)
, scavanger receptor class B type 1
, CD36 antigen (collagen type I receptor, thrombospondin receptor-like 1)