Browse our AJUBA Proteins (AJUBA)

Full name:
Ajuba LIM Protein Proteins (AJUBA)
On www.antibodies-online.com are 5 Ajuba LIM Protein (AJUBA) Proteins from 4 different suppliers available. Additionally we are shipping AJUBA Antibodies (25) and many more products for this protein. A total of 33 AJUBA products are currently listed.
Synonyms:
Jub
list all proteins Gene Name GeneID UniProt
AJUBA 84962 Q96IF1
AJUBA 16475 Q91XC0
AJUBA 85265 Q5U2Z2

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AJUBA Proteins (AJUBA) by Origin

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Human Ajuba LIM Protein (AJUBA) interaction partners

  1. Mechanistic investigations reveal that AJUBA specifically binds the FERM domain of JAK1 (show JAK1 Proteins) to dissociate JAK1 (show JAK1 Proteins) from the IFNgamma recepter, resulting in an inhibition of STAT1 (show STAT1 Proteins) phosporylation and concomitantly its nuclear translocation. Clinically, the level of AJUBA in CRC (show CALR Proteins) specimens is negatively correlated with the levels of IFIT2 (show IFIT2 Proteins) and pSTAT1

  2. AJUBA is a LIM domain protein and contributes to the formation and stability of cadherin-mediated cell-cell adhesion. Loss of AJUBA enhances Prostate cancer cell migration and downregulation of AJUBA expression is observed in metastatic Prostate cancer.

  3. Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinomas to treatment with PLK1 inhibitors.

  4. mitotic phosphorylation of Ajuba is sufficient to promote cell proliferation and anchorage-independent growth in vitro and tumorigenesis in vivo

  5. The results in this study uncovered that JUB was a regulator involved in proliferation of glioma cells, and it could be used as a potential therapeutic target for glioma.

  6. AJUBA negatively regulates YAP activity through the LATS family, and inactivation of AJUBA is a novel key mechanism in malignant mesothelioma cell proliferation

  7. the LIM protein JUB serves as a tumor-promoting gene in colorectal cancer by promoting epithelial-mesenchymal transition, a critical process of metastasis.

  8. The LIM (show PDLIM5 Proteins) domain of Ajuba can competitively bind to the N-terminal of Aurora-A (show AURKA Proteins), and inhibited the interaction between N-terminal and C-terminal of Aurora A (show AURKA Proteins).

  9. A Rac-PAK1-Ajuba feedback loop integrates spatiotemporal signaling with actin remodeling at cell-cell contacts and stabilizes preassembled cadherin complexes.

  10. Ajuba contains functional nuclear-receptor interacting motifs and selectively interacts with retinoic acid receptors and rexinoid receptor subtypes.

Mouse (Murine) Ajuba LIM Protein (AJUBA) interaction partners

  1. Ajuba recruits p300/CBP (show CREBBP Proteins) via its LIM (show PDLIM5 Proteins) domain and facilitates p300/CBP (show CREBBP Proteins) binding to PPARg (show PPARG Proteins). Moreover, Ajuba, PPARg (show PPARG Proteins), p300/CBP (show CREBBP Proteins) can cooperatively occupy the PPARg (show PPARG Proteins) target promoters and concomitantly increases histone acetylation at these loci.

  2. Ajuba is a novel coactivator for liver X receptors and may play important role in lipid and glucose metabolism.

  3. Findings support the importance of adhesion molecules (VE-cadherin and CD31), survivin, and Ajuba in modulating the Hippo pathway, which regulates, in part, proliferation and survival in hemangioendotheliomas.

  4. PKD1-mediated phosphorylation of SNAI1 occurs in the nucleus and generates a nuclear, inactive DNA/SNAI1 complex that shows decreased interaction with its co-repressor Ajuba.

  5. This paper presents evidence indicating that the human and mouse Ajuba is a new cytosolic component of the IL-1 (show IL1A Proteins) signaling pathway, influencing the assembly and activity of the aPKC/p62 (show GTF2H1 Proteins)/TRAF6 (show TRAF6 Proteins) multiprotein signaling complex.

  6. identification of the protein arginine methyltransferase 5 (PRMT5 (show PRMT5 Proteins)) as an effector recruited to SNAIL (show SNAI1 Proteins) through an interaction with AJUBA that functions to repress the SNAIL (show SNAI1 Proteins) target gene, E-cadherin (show CDH1 Proteins)

AJUBA Protein Profile

Protein Summary

cytoplasmic LIM protein that binds glial glutamate transporter GLT-1 and is proposed to allow glial glutamate transporter GLT-1 to regulate intracellular signaling or interact with the cytoskeleton

Alternative names and synonyms associated with AJUBA

  • ajuba LIM protein (AJUBA)
  • ajuba LIM protein (Ajuba)
  • jub, ajuba homolog (Xenopus laevis) (AJUBA)
  • Jub protein

Protein level used designations for Ajuba LIM Protein Proteins (AJUBA)

LIM domain-containing protein ajuba , jub, ajuba homolog , protein ajuba , Ajuba protein , ajuba homolog

GENE ID SPECIES
84962 Homo sapiens
480244 Canis lupus familiaris
16475 Mus musculus
85265 Rattus norvegicus
519937 Bos taurus
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