Browse our CENPA (CENPA) ELISA Kits

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Centromere Protein A ELISA Kits (CENPA)
On www.antibodies-online.com are 23 Centromere Protein A (CENPA) ELISA Kits from 5 different suppliers available. Additionally we are shipping CENPA Antibodies (134) and CENPA Proteins (19) and many more products for this protein. A total of 183 CENPA products are currently listed.
Synonyms:
BcDNA:RE21270, cenH3, CenH3/CID, CenH3[Cid], Cenp-a, CENP-A/Cid, CENP-C, cenpA, CenpA/CID, cenpx, CG13329, Cid, CID/CENP-A, Cid[Mel], Dmel\\CG13329, RGD1563607, sim2
list all ELISA KIts Gene Name GeneID UniProt
CENPA 1058 P49450
CENPA 12615 O35216
CENPA 298850  

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More ELISA Kits for CENPA Interaction Partners

Fruit Fly (Drosophila melanogaster) Centromere Protein A (CENPA) interaction partners

  1. centromere assembly factors CAL1 (show CALCA ELISA Kits) and CENP-C are required for meiotic chromosome segregation, CENP-A assembly and maintenance on sperm, as well as fertility

  2. identify two co-evolving regions, CENP-A L1 and the CAL1 (show CALCA ELISA Kits) N terminus, as critical for lineage-specific CENP-A incorporation

  3. A novel role has been described for the histone acetyltransferase (show HAT ELISA Kits) Hat1 (show HAT1 ELISA Kits) in the CENP-A/CID assembly pathway in Drosophila melanogaster.

  4. CENP-A assembly by its loading factor, CAL1, requires RNAPII-mediated transcription of the underlying DNA

  5. The amount of Cid that is loaded during each cell cycle appears to be determined primarily by the preexisting centromeric Cid, with little flexibility for compensation of accidental losses.

  6. CID nucleosomes are octameric in vivo and that CID dimerization is essential for correct centromere assembly.

  7. The F box protein (show FBXO30 ELISA Kits) partner of paired (Ppa (show FBXL14 ELISA Kits)) mediates CenH3(CID) stability in Drosophila. Ppa (show FBXL14 ELISA Kits) depletion results in increased CenH3(CID) levels. Ppa (show FBXL14 ELISA Kits) physically interacts with CenH3(CID) through the CATD (show CTSD ELISA Kits)(CID) that mediates Ppa (show FBXL14 ELISA Kits)-dependent CenH3(CID) stability.

  8. Drosophila CENP-C is essential for centromere identity.

  9. Cid allows for contacts betwen DNA and histones and specific targeting

  10. Results suggest that CID mislocalization promotes formation of ectopic centromeres and multicentric chromosomes, which causes chromosome missegregation, aneuploidy, and growth defects.

Human Centromere Protein A (CENPA) interaction partners

  1. CENP-A specifically binds alpha satellite non-coding RNAs. Loss of CENP-A does not affect transcript abundance or stability.

  2. Evolutionarily conserved flexible ends of the CENP-A nucleosomes are essential to ensure the fidelity of the mitotic pathway.

  3. These data implicate the insulin (show INS ELISA Kits)-FoxM1 (show FOXM1 ELISA Kits)/PLK1 (show PLK1 ELISA Kits)/CENP-A pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.

  4. Findings indicate that expression of the scleroderma autoantigens IFI-16 (show IFI16 ELISA Kits) and CENPs (show APITD1 ELISA Kits), which are associated with severe vascular disease, is increased in vascular progenitors and mature endothelial cells. High level, lineage-enriched expression of autoantigens may explain the striking association between clinical phenotypes and the immune targeting of specific autoantigens.

  5. KAT7 (show MYST2 ELISA Kits)-containing acetyltransferases associating with the Mis18 complex provides competence for histone turnover/exchange activity on alphoid DNA and prevents Suv39h1 (show SUV39H1 ELISA Kits)-mediated heterochromatin invasion into centromeres.

  6. CENP-A mutants that cannot be phosphorylated at Ser68 or ubiquitinated at Lys124 assemble efficiently at centromeres during G1, mediate early events in centromere establishment at an ectopic chromosomal locus, and maintain centromere function indefinitely.

  7. elevated CENP-A expression is coupled to malignant progression of numerous types of cancer. It may be useful as a biomarker of poor patient prognosis and as a predictive biomarker for taxane-based chemotherapy.

  8. CENP-C (show CENPC1 ELISA Kits) and CENP-I (show CENPI ELISA Kits) are key factors connecting kinetochore to CENP-A assembly.

  9. The authors found that the nucleosome shape change directed by CENP-A is dominated by lateral passing of two DNA gyres (gyre sliding).

  10. the CRL4 complex containing RBBP7 (show RBBP7 ELISA Kits) (CRL4(RBBP7 (show RBBP7 ELISA Kits))) might regulate mitosis by promoting ubiquitin-dependent loading of newly synthesized CENP-A during the G1 phase of the cell cycle.

Mouse (Murine) Centromere Protein A (CENPA) interaction partners

  1. evolutionarily conserved flexible ends of the CENP-A nucleosomes are essential to ensure the fidelity of the mitotic pathway.

  2. These data implicate the insulin (show INS ELISA Kits)-FoxM1 (show FOXM1 ELISA Kits)/PLK1 (show PLK1 ELISA Kits)/CENP-A pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.

  3. CPCs maintain relatively high levels of CENP-A early in life, which is necessary for sustaining proliferation, inhibiting senescence, and promoting survival following differentiation of CPCs.

  4. Results report that the level of CENP-A, a protein required for cell division, declines precipitously with age in an islet-specific manner.

  5. Cenpa, Cenpb (show CENPB ELISA Kits), and Bub3 (show BUB3 ELISA Kits), but not Cenpc (show CENPC1 ELISA Kits), interacted with PARP-1 (show PARP1 ELISA Kits)

  6. The centromere-targeting domain of CENP-A is both necessary and sufficient for recruitment to double-strand breaks. CENP-A accumulation at DNA breaks is enhanced by active non-homologous end-joining but does not require DNA-PKcs (show PRKDC ELISA Kits) or Ligase IV.

Xenopus laevis Centromere Protein A (CENPA) interaction partners

  1. CENP-A assembly into chromatin requires unidentified deoxycytidine deaminase (show APOBEC3G ELISA Kits) and UNG2 (show CCNO ELISA Kits), a uracil DNA glycosylase (show UNG ELISA Kits).

  2. CENP-A deposition at the centromeres is dependent on HJURP.

CENPA Antigen Profile

Antigen Summary

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Alternative names and synonyms associated with CENPA

  • centromere identifier (cid) Elisa Kit
  • centromere protein-A (CENP-A) Elisa Kit
  • centromere protein A (cenpa) Elisa Kit
  • centromeric histone-3 like protein (cenp-A) Elisa Kit
  • centromere-specific histone H3 CENP-A (cnp1) Elisa Kit
  • cenp-A (HAN_3g422) Elisa Kit
  • centromere protein A (Cenp-a) Elisa Kit
  • centromere protein A (CENPA) Elisa Kit
  • centromere protein A (CMU_016480) Elisa Kit
  • centromere protein A (Cenpa) Elisa Kit
  • centromere protein A-like (LOC100353660) Elisa Kit
  • histone H3-like centromeric protein A (cenpa) Elisa Kit
  • BcDNA:RE21270 Elisa Kit
  • cenH3 Elisa Kit
  • CenH3/CID Elisa Kit
  • CenH3[Cid] Elisa Kit
  • Cenp-a Elisa Kit
  • CENP-A/Cid Elisa Kit
  • CENP-C Elisa Kit
  • cenpA Elisa Kit
  • CenpA/CID Elisa Kit
  • cenpx Elisa Kit
  • CG13329 Elisa Kit
  • Cid Elisa Kit
  • CID/CENP-A Elisa Kit
  • Cid[Mel] Elisa Kit
  • Dmel\\CG13329 Elisa Kit
  • RGD1563607 Elisa Kit
  • sim2 Elisa Kit

Protein level used designations for Centromere Protein A (CENPA) ELISA Kits

CG13329-PA , centromere identifier protein , centromere protein A , cid-PA , centromere protein-A , centromere protein, Xenopus , histone H3-like centromeric protein A , centromeric histone-3 like protein , cenp-A , centromere autoantigen A , centromere protein A, 17kDa , centromere-specific histone , centrosomin A , CENP-A , ggCENP-A

GENE ID SPECIES
36495 Drosophila melanogaster
407119 Bos taurus
549339 Xenopus (Silurana) tropicalis
857118 Guillardia theta
2539658 Schizosaccharomyces pombe 972h-
5739547 Hemiselmis andersenii
100233153 Nasonia vitripennis
459086 Pan troglodytes
697312 Macaca mulatta
6995376 Cryptosporidium muris RN66
613898 Bos taurus
1058 Homo sapiens
12615 Mus musculus
298850 Rattus norvegicus
475692 Canis lupus familiaris
100724949 Cavia porcellus
100113359 Gallus gallus
101110750 Ovis aries
735079 Xenopus laevis
100689459 Cricetulus griseus
100353660 Oryctolagus cuniculus
100302659 Danio rerio
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