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Browse our FOXC1 Proteins (FOXC1)

Full name:
Forkhead Box C1 Proteins (FOXC1)
On are 5 Forkhead Box C1 (FOXC1) Proteins from 4 different suppliers available. Additionally we are shipping FOXC1 Antibodies (91) and FOXC1 Kits (20) and many more products for this protein. A total of 124 FOXC1 products are currently listed.
ARA, CFKH-1, ch, fkh-1, Fkh1, FKHL7, foxc1, FREAC-3, FREAC3, frkhda, IGDA, IHG1, IRID1, Mf1, Mf4, RIEG3, xfd-11
list all proteins Gene Name GeneID UniProt
FOXC1 2296 Q12948
FOXC1 17300 Q61572
Rat FOXC1 FOXC1 364706  

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FOXC1 Proteins (FOXC1) by Origin

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More Proteins for FOXC1 Interaction Partners

Human Forkhead Box C1 (FOXC1) interaction partners

  1. Elevated expression of FOXC1 enhanced the invasion ability of BLCB cells in vitro.

  2. this report describes an Italian family in which four subjects share brachydactyly type E and a 3 Mb microduplication in region 6p25. The duplication involves the gene FOXC1, expressed during the osteoblast differentiation, which appears a potential candidate gene for brachydactyly.

  3. miR (show MLXIP Proteins)-495 acts as a tumour suppressor gene by targeting FOXC1 at the post-transcriptional level in endometrial cancer

  4. This report presents the clinical characteristics of a Belgian family with a 3.4 Mb deletion of chromosome 6p25, including the FOXC1 gene.

  5. data reveal the presence of translation regulatory sequences in the UTRs of FOXC1 and provide evidence for a possible role of rare FOXC1 variants as modifying factors of goniodysgenesis in primary congenital glaucoma.

  6. ARS (show SLURP1 Proteins) is an autosomal dominant disorder with high penetration. It is primarily caused by a mutation of the pituitary homeobox 2 (PITX2 (show PITX2 Proteins)) or forkhead box C1 (FOXC1) gene. Mutations in PITX2 (show PITX2 Proteins) on chromosome 4q25, or in FOXC1 at 6p25, have been identified in approximately 40% to 70% of patients with ARS (show SLURP1 Proteins)

  7. These data suggest that deregulation of FOXC1 or its downstream genes play a major role in the pathogenesis of coarctation of the aorta in humans.

  8. Disruptions of enhancers near FOXC1 and GMDS (show GMDS Proteins) may influence brain development.

  9. We report a novel FOXC1 mutation (p. R127L) in a three-generation family with three ARS (show SLURP1 Proteins) and heart defect (show Vcan Proteins) patients.

  10. FOXC1 directly binds Gli2 and potentiates Gli2 DNA-binding activity.

Mouse (Murine) Forkhead Box C1 (FOXC1) interaction partners

  1. Foxc1 and Foxc2 (show FOXC2 Proteins) maintain glomerular podocyte integrity by regulating the gene expression.

  2. Foxc1 and Foxc2 (show FOXC2 Proteins) have a role in kidney and axial skeleton development.

  3. FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential.FOXC1 is necessary to establish a multiple-bulge hair follicle architecture.

  4. deletion of Foxc1 and Foxc2 (show FOXC2 Proteins) specifically in Pax3 (show PAX3 Proteins)-positive cells affects cell fate choices in the dermomyotome of somites at forelimb level, promoting the myogenic cell fate at the expense of endothelial cells that migrate to the limb

  5. Foxc1 is an important transcriptional partner of Ihh-Gli2 signalling during endochondral ossification, and that disruption of the Foxc1-Gli2 interaction causes skeletal abnormalities observed in the Axenfeld-Rieger syndrome.

  6. In self-renewing stem cells (SCs), Foxc1 activates Nfatc1 and bone morphogenetic protein (BMP) signaling, two key mechanisms that govern quiescence. These findings reveal a dynamic, cell-intrinsic mechanism used by hair follicle SCs to reinforce quiescence upon self-renewal and suggest a unique ability of SCs to maintain cell identity.

  7. These observations reveal an essential role for Foxc1 in the early stage of vascular formation in the telencephalon.

  8. loss of Foxc1 non-autonomously induces a rapid and devastating decrease in embryonic cerebellar ventricular zone radial glial proliferation and concurrent increase in cerebellar neuronal differentiation

  9. A loss of Foxc1 function affects skull bone formation of the apical region.

  10. Together our data demonstrates that Foxc1 - Fgf8 (show FGF8 Proteins) signaling regulates mammalian jaw patterning and provides a mechanistic basis for the pathogenesis of syngnathia.

FOXC1 Protein Profile

Protein Summary

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined\; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly.

Alternative names and synonyms associated with FOXC1

  • forkhead box C1 (foxc1)
  • forkhead box C1 (FOXC1)
  • Forkhead box protein C1 (foxc1)
  • forkhead box C1 (Foxc1)
  • forkhead box C1 (foxc1-b)
  • ARA protein
  • CFKH-1 protein
  • ch protein
  • fkh-1 protein
  • Fkh1 protein
  • FKHL7 protein
  • foxc1 protein
  • FREAC-3 protein
  • FREAC3 protein
  • frkhda protein
  • IGDA protein
  • IHG1 protein
  • IRID1 protein
  • Mf1 protein
  • Mf4 protein
  • RIEG3 protein
  • xfd-11 protein

Protein level used designations for Forkhead Box C1 Proteins (FOXC1)

forkhead box protein C1 , forkhead box C1 , Forkhead box protein C1 , forkhead, drosophila, homolog-like 7 , forkhead-related activator 3 , forkhead-related protein FKHL7 , forkhead-related transcription factor 3 , forkhead/winged helix-like transcription factor 7 , myeloid factor-delta , FREAC-3 , MF-1 , congenital hydrocephalus , mesoderm/mesenchyme forkhead 1 , transcription factor FKH-1 , forkhead box protein C1-B , winged helix protein CWH-6 , winged-helix transcription factor

493250 Xenopus (Silurana) tropicalis
722918 Macaca mulatta
750577 Pan troglodytes
100028901 Monodelphis domestica
100195202 Salmo salar
2296 Homo sapiens
17300 Mus musculus
734912 Xenopus laevis
364706 Rattus norvegicus
395856 Gallus gallus
101102186 Ovis aries
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