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Prominent foxp1 expression is detected in many regions of the developing central nervous system, especially in midbrain-hindbrain boundary, hindbrain, and spinal cord.
results reveal a novel regulatory pathway, underscoring a previously unknown and interconnected key role of PUM1 (show PUM1 Proteins)/2 and FOXP1 in regulating normal hematopoietic stem/progenitor cell and leukemic cell growth.
Although the mutant huntingtin (show HTT Proteins) gene is expressed widely, neurons of the striatum and cortex are selectively affected in Huntington's disease (HD). Our results suggest that this selectivity is attributable to the reduced expression of Foxp1, a protein expressed selectively in striatal and cortical neurons that plays a neuroprotective role in these cells.
the activity of multiple alternate FOXP1 promoters to produce multiple protein isoforms is likely to regulate B-cell maturation (show TNFRSF17 Proteins).
these novel insights into the function of FOXP1 isoforms in controlling the transcriptional program, survival and differentiation of B cells advance our understanding of the role of FOXP1 in lymphomagenesis and further enhance the value of FOXP1 for diagnostics, prognostics, and treatment of DLBCL patients.
Data indicate that forkhead box P1 protein (FOXP1) as a target of microRNA miR (show MLXIP Proteins)-92a in primary mediastinal large B-cell lymphoma (PMBL).
Results suggest that domain swapping in FoxP1 is at least partially linked to monomer folding stability and follows an unusual three-state folding mechanism, which might proceed via transient structural changes rather than requiring complete protein unfolding as do most domain-swapping proteins
these data identify FOXP1 as an essential transcriptional regulator for primary human CD4 (show CD4 Proteins)(+) T cells and suggest its potential important role in the development of PTCL.
Kaplan-Meier survival analysis showed that pancreatic ductal adenocarcinoma patients with negative forkhead box P1 and forkhead box O3a (show FOXO3 Proteins) expression survived significantly shorter than patients with positive forkhead box P1 and forkhead box O3a (show FOXO3 Proteins) expression (p = 0.000).
Study identified USP15 (show USP15 Proteins) as having recurrent de novo loss of function mutations and discovered evidence supporting two other known genes with recurrent de novo variants (FOXP1 and KDM5B (show KDM5B Proteins)).
FOXP1 knockdown significantly suppressed growth of HCC (show FAM126A Proteins) cells and induced G1/S phase arrest.
These results indicate that FOXP1 attenuates MSC (show MSC Proteins) senescence by orchestrating their cell-fate switch while maintaining their replicative capacity in a dose- and age-dependent manner.
studies suggest that Foxp1 enforces naive CD8 (show CD8A Proteins)(+) T cell quiescence by simultaneously repressing key pathways in both cellular metabolism and cell cycle progression
Loss of Foxp1 results in loss of suture and fiber cell alignment, which eventually causes lens opacity, suggesting that Foxp1 has a key role in establishing cortical lens architecture.
we demonstrated for the first time that Foxp1 and Foxp2 (show FOXP2 Proteins) are expressed during craniofacial development. Our data suggest that the Foxp (show FOXP2 Proteins) genes may regulate development of the aboral and posterior regions of the jaw.
Combined loss of all three Foxp1/2/4 family members in the developing anterior foregut endoderm leads to a loss of lung endoderm lineage commitment and subsequent development. Foxp1/2/4 deficient lungs express high levels of transcriptional regulators not normally expressed in developing lung. Foxp1 binds to conserved forkhead DNA binding sites within the Hoxa9 (show HOXA9 Proteins)-13 cluster, indicating a direct repression mechanism.
We show that Foxp1 and the androgen receptor (show AR Proteins) are co-expressed in striatal medium spiny neurons and that brain-specific (show CALY Proteins) androgen receptor (show AR Proteins) KO (ArNesCre) mice exhibit reduced Foxp1 expression in the striatum at E17.5 and P7.5 and an increased Foxp2 (show FOXP2 Proteins) level in the cortex at P7.5. Thus, androgens may contribute to sex-specific differences in Foxp1 and Foxp2 (show FOXP2 Proteins) expression and ultrasonic vocalizations
This study demonstrated the utility of FoxP1 to label MSNs in vitro and following neural transplantation, and show that FoxP1 is required for DARPP-32 (show PPP1R1B Proteins) positive MSN (show MSN Proteins) differentiation in vitro.
En1 (show EN1 Proteins)-null cells also fail to express the transcription factor FoxP1, suggesting that FoxP1 lies downstream of En1 (show EN1 Proteins).
The response of CPLX1 and Foxp1 levels to SNCA deficiency supports the notion that these factors are regulated by altered physiological function of alpha-synuclein.
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.
forkhead box P1
, forkhead box protein P1-B
, forkhead box protein P1-like
, forkhead box protein P1
, fork head-related protein like B
, glutamine-rich factor 1
, forkhead-related transcription factor 1