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Prominent foxp1 expression is detected in many regions of the developing central nervous system, especially in midbrain-hindbrain boundary, hindbrain, and spinal cord.
Kaplan-Meier survival analysis showed that pancreatic ductal adenocarcinoma patients with negative forkhead box P1 and forkhead box O3a (show FOXO3 Proteins) expression survived significantly shorter than patients with positive forkhead box P1 and forkhead box O3a (show FOXO3 Proteins) expression (p = 0.000).
Study identified USP15 (show USP15 Proteins) as having recurrent de novo loss of function mutations and discovered evidence supporting two other known genes with recurrent de novo variants (FOXP1 and KDM5B (show KDM5B Proteins)).
FOXP1 knockdown significantly suppressed growth of HCC (show FAM126A Proteins) cells and induced G1/S phase arrest.
FOXP1 has protein-protein interaction with NFAT1 (show NFAT1 Proteins) on DNA and enhances breast cancer cell migration by repressing NFAT1 (show NFAT1 Proteins) transcriptional activity.
FOXP1 functions as an oncogene (show RAB1A Proteins) in promoting cancer stem cell-like characteristics in ovarian cancer cells.
The findings highlight that de novo FOXP1 variants are a cause of sporadic intellectual disability and emphasize the importance of this transcription factor in neurodevelopment.
we provide supportive evidence that genetic variants at FOXP1, BARX1 (show BARX1 Proteins), and FOXF1 (show FOXF1 Proteins) confer risk for the development of EAC (show CYLD Proteins).
Cell-line derived FOXP1 target genes that were highly correlated with FOXP1 expression in primary DLBCL accurately segregated the corresponding clinical subtypes of a large cohort of primary DLBCL isolates
S1PR2 (show S1PR2 Proteins) is repressed by FOXP1 in activated B-cell and germinal center B-cell DLBCL cell lines with aberrantly high FOXP1 levels; S1PR2 (show S1PR2 Proteins) expression is further inversely correlated with FOXP1 expression in 3 DLBCL patient cohorts.
FOXP1 represents a novel regulator of genes targeted by the class II MHC (show HLAE Proteins) transactivator CIITA (show CIITA Proteins) and CD74 (show CD74 Proteins).
we demonstrated for the first time that Foxp1 and Foxp2 (show FOXP2 Proteins) are expressed during craniofacial development. Our data suggest that the Foxp (show FOXP2 Proteins) genes may regulate development of the aboral and posterior regions of the jaw.
Combined loss of all three Foxp1/2/4 family members in the developing anterior foregut endoderm leads to a loss of lung endoderm lineage commitment and subsequent development. Foxp1/2/4 deficient lungs express high levels of transcriptional regulators not normally expressed in developing lung. Foxp1 binds to conserved forkhead DNA binding sites within the Hoxa9 (show HOXA9 Proteins)-13 cluster, indicating a direct repression mechanism.
We show that Foxp1 and the androgen receptor (show AR Proteins) are co-expressed in striatal medium spiny neurons and that brain-specific (show CALY Proteins) androgen receptor (show AR Proteins) KO (ArNesCre) mice exhibit reduced Foxp1 expression in the striatum at E17.5 and P7.5 and an increased Foxp2 (show FOXP2 Proteins) level in the cortex at P7.5. Thus, androgens may contribute to sex-specific differences in Foxp1 and Foxp2 (show FOXP2 Proteins) expression and ultrasonic vocalizations
This study demonstrated the utility of FoxP1 to label MSNs in vitro and following neural transplantation, and show that FoxP1 is required for DARPP-32 (show PPP1R1B Proteins) positive MSN (show MSN Proteins) differentiation in vitro.
En1 (show EN1 Proteins)-null cells also fail to express the transcription factor FoxP1, suggesting that FoxP1 lies downstream of En1 (show EN1 Proteins).
The response of CPLX1 and Foxp1 levels to SNCA deficiency supports the notion that these factors are regulated by altered physiological function of alpha-synuclein.
These results identify a previously unrecognized role for FOXP1 in the transcriptional control of hepatic glucose homeostasis.
results demonstrate critical roles of Foxp1 in the radial migration and morphogenesis of cortical neurons during development.
a novel role for Foxp1 in controlling HFSC proliferation with cellular dynamic location in response to oxidative stress during hair cycling
Collectively, these findings reveal an important role for the FOXP1, 2, and 4 proteins in governing postnatal alpha cell expansion and function.
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.
forkhead box P1
, forkhead box protein P1-B
, forkhead box protein P1-like
, forkhead box protein P1
, fork head-related protein like B
, glutamine-rich factor 1
, forkhead-related transcription factor 1