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miR (show MLXIP Proteins)-1307 could promote ovarian cancer chemoresistance by targeting the ING5 expression and miR (show MLXIP Proteins)-1307 might serve as a therapeutic target for ovarian cancer.
miR (show MLXIP Proteins)-331-3p is upregulated by HBV and promotes proliferation of hepatocellular carcinoma cells though repression of ING5 expression.
Suggest that ING5 expression might be a good marker for gastric carcinogenesis and its subsequent progression by inhibiting proliferation, growth, migration, invasion and metastasis.
Loss of ING5 expression is associated with lung cancer.
Identified ING5 as a novel CDK2 (show CDK2 Proteins) substrate. ING5 is phosphorylated at a single site, threonine 152, by cyclin E (show CCNE1 Proteins)/CDK2 (show CDK2 Proteins) and cyclin A (show CCNA2 Proteins)/CDK2 (show CDK2 Proteins). This site is also phosphorylated in cells in a cell cycle dependent manner, consistent with it being a CDK2 (show CDK2 Proteins) substrate.
Results showed that ING5 gene expression is inhibited by miR (show MLXIP Proteins)-193a-3p and is instrumental in miR (show MLXIP Proteins)-193a-3p's role in activating BCa (show BLNK Proteins) chemoresistance.
Data indicate that ING5 associates with Tip60 (KAT5 (show KAT5 Proteins)) to form a complex with p53 (show TP53 Proteins).
ING5 down-regulation promotes bone mesenchymal stem cell proliferation.
Results indicate that ING5 is a growth suppressor with suppressed expression in AML whose functions depend on its interaction with INCA1.
EBNA3C negatively regulate p53 (show TP53 Proteins)-mediated functions by interacting with ING4 (show ING4 Proteins) and ING5.
The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.
inhibitor of growth family, member 5
, inhibitor of growth protein 5