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KDM5A-mediated H3K4me3 modification participated in the etiology of osteoporosis and may provide new strategies to improve the clinical efficacy of BMP2 (show BMP2 Proteins) in osteoporotic conditions.
KDM5A demethylates H3K4 to allow ZMYND8-NuRD to operate within damaged chromatin to repair DNA double strand breaks.
the radiation sensitivity observed following depletion of Jarid1A is not caused by a deficiency in repair of DNA double-strand breaks.
Treatment-induced temozolimide resistance in glioblastoma cells involves KDM5A mediated epigenetic mechanisms.
Characterization of a Linked Jumonji (show JARID2 Proteins) Domain of the KDM5/JARID1 Family of Histone H3 (show HIST3H3 Proteins) Lysine 4 Demethylases.
KDM5A is regulated by its reader domain through a positive-feedback mechanism
Data indicate that lysine (K)-specific demethylase 5A RBP2 (JARID1A; KDM5A) epigenetically downregulated micrRNA-21 (miR (show MLXIP Proteins)-21) in blast transformation of chronic myeloid leukemia (show BCL11A Proteins) (CML (show BCR Proteins)).
LSD1 (show KDM1A Proteins) is a more sensitive molecular marker than RBP2 on thyroid cancer diagnosis.
MiR (show MLXIP Proteins)-212 directly regulates the expression of RBP2 and inhibits cell growth in gastric cancer, which may provide new clues to treatment.
RBP2 is critical for breast cancer metastasis to the lung in multiple in vivo models. Mechanistically, RBP2 promotes metastasis as a pleiotropic positive regulator of many metastasis genes, including TNC (show TNC Proteins).
Kdm5a associates with p50 (show LSP1 Proteins) and binds to the Socs1 (show SOCS1 Proteins) promoter region in resting natural killer cells.
Maintenance of gene silencing by the coordinate action of the H3K9 methyltransferase G9a/KMT1C (show EHMT2 Proteins) and the H3K4 demethylase (show MBD2 Proteins) Jarid1a/KDM5A.
In terminally differentiated cells, common KDM5A and E2F4 (show E2F4 Proteins) gene targets were bound by the pRB (show PGR Proteins)-related protein p130, a DREAM complex component.
Study reports that RBP2 (show RBP2 Proteins) is a demethylase (show MBD2 Proteins) that specifically catalyzes demethylation on histone H3 (show HIST3H3 Proteins) lysine 4, whose methylation is normally associated with transcriptionally active genes.
JARID1a formed a complex with CLOCK-BMAL1 (show ARNTL Proteins) which was recruited to Per2 (show PER2 Proteins) promoter;it increased histone acetylation by inhibiting histone deacetylase 1 (show HDAC1 Proteins) function and enhanced transcription by CLOCK-BMAL1 (show ARNTL Proteins); JARID1a depletion shortened period of circadian rhythms
KDM5A interacts physically with RBP-J (show RBPJ Proteins)
mutation can downregulate cardiac cell proliferation by repressing cyclin D1 (show CCND1 Proteins) expression in the same way as jumonji (show JARID2 Proteins)
A functional interplay between the PRC2 complex and the H3K4me3 demethylase (show MBD2 Proteins) Rbp2 (Jarid1a) in mouse embryonic stem (ES) cells.
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this protein.
jumonji, AT rich interactive domain 1A (Rbp2 like)
, lysine-specific demethylase 5A
, jumonji, AT rich interactive domain 1A
, lysine (K)-specific demethylase 5A
, JARID1A variant protein-like
, jumonji AT-rich interactive domain 1A
, retinoblastoma binding protein 2
, Jumonji, AT rich interactive domain 1A (RBP2-like)
, histone demethylase JARID1A
, jumonji/ARID domain-containing protein 1A
, retinoblastoma-binding protein 2