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Genome-wide analysis indicated that LMO2 is required at the hemangioblast stage to position the TAL1 (show TAL1 ELISA Kits)/LMO2/LDB1 (show LDB1 ELISA Kits) complex to regulatory elements that are important for the establishment of the hematopoietic developmental program.
DNM2 (show DNM2 ELISA Kits) mutations cooperate with Lmo2 T-cell oncogenes by enhancing IL-7 (show IL7 ELISA Kits) signalling.
Hhex (show HHEX ELISA Kits) regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.
HHEX (show HHEX ELISA Kits) is a direct transcriptional target of LMO2 consistent with its concordant gene expression.
GATA2 (show GATA2 ELISA Kits) and Lmo2 cooperatively regulate VEGF (show VEGFA ELISA Kits)-induced angiogenesis and lymphangiogenesis via NRP2 (show NRP2 ELISA Kits).
a regulatory hierarchy of HOX (show MSH2 ELISA Kits) control of LMO2 in normal development
Lyl1 is critical for all oncogenic functions of Lmo2, including upregulation of a stem cell-like gene signature, aberrant self-renewal of thymocytes, and subsequent generation of T-cell leukemia.
A model in which the distal control region functions through a chromatin looping mechanism to contact and enhance Lmo2 transcription specifically in erythroid cells.
Studied the solution structure of Lmo2(LIM2 (show LHX2 ELISA Kits)) /Ldb1 (show LDB1 ELISA Kits)(LID) complex. Results show modular binding of tandem LIM (show PDLIM5 ELISA Kits) domains in Lmo2 to tandem linear motifs in Ldb1 (show LDB1 ELISA Kits) is accompanied by several disorder-to-order transitions/ conformational changes in both proteins.
Studies demonstrate that Etv2 is expressed during and required for yolk sac hematoendothelial development, and that Lmo2 is one of the downstream targets of Etv2.
This article demonstrates a novel and unexpected function of the LMO2 oncogenic transcription factor in controlling DNA replication that we unravelled via an unbiased proteome-wide screen for LMO2-interacting partners.
Findings suggest that LMO2 loss may be a good predictor for the presence of MYC (show MYC ELISA Kits) translocation in large B-cell lymphoma.
FOXP3 (show FOXP3 ELISA Kits) binds LMO2 in vitro, resulting in decreased interaction between LMO2 and TAL1 (show TAL1 ELISA Kits), providing a molecular mechanism for FOXP3 (show FOXP3 ELISA Kits)-mediated transcriptional modulation in T-ALL.
recurrent activating intronic mutations of LMO2, a prominent oncogene (show RAB1A ELISA Kits) in T-cell acute lymphoblastic leukemia (T-ALL). Heterozygous mutations were identified in PF-382 and DU.528 T-ALL cell lines in addition to 3.7% of pediatric (6 of 160) and 5.5% of adult (9 of 163) T-ALL patient samples.
Data indicate a novel functional mechanism of LMO2 in facilitating the delivery of actin monomers to the branched microfilament and increasing lamellipodia/filopodia formation in basal-type breast cancer cells.
we demonstrate previously unrecognized mechanisms by which LMO2 alters human T-cell development in vivo; these mechanisms correlate with human T-ALL leukemogenesis.
this study revealed a novel function of LMO2 involving in the regulatory hierarchy of UBA6 (show UBA6 ELISA Kits)-USE1-FAT10ylation pathway by targeting the E1 enzyme (show ENOPH1 ELISA Kits) UBA6 (show UBA6 ELISA Kits).
LMO2 is a useful marker for immunophenotypic assessment of thymic neoplasms.
LMO2 was associated with increased levels of cytosolic p27(Kip1 (show CDKN1B ELISA Kits)) protein.
that suppression of MIR223 expression, as compared with controls, is associated with lack of differentiation and adverse cytogenetic profile, but unrelated with LMO2 protein expression or overall survival.
a loss-of-function mutation in lmo2, a gene specifically required for hematopoiesis and vascular development, results in failure of optic fissure closure
in the absence of inducers of erythroid or myeloid haematopoiesis, Scl/Tal1 (show TAL1 ELISA Kits)-Lmo2-induced haemangioblasts differentiate into endothelial cells
Transcriptional regulation of lmo2 promoter during hematopoietic and vascular development in zebrafish is elucidated.
Scl (show TAL1 ELISA Kits)/Lmo2 complex does not appear to autoregulate, as neither gene's expression is affected by depletion of the other
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.
, LIM domain only 2 (rhombotin-like 1)
, LIM domain only protein 2
, LIM only 2
, T-cell translocation protein 2
, cysteine-rich protein TTG-2
, T-cell translocation gene 2
, rhombotin 2
, rhombotin-like 1
, LIM domain only-2