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Browse our MITF Proteins (MITF)

Full name:
Microphthalmia-Associated Transcription Factor Proteins (MITF)
On are 5 Microphthalmia-Associated Transcription Factor (MITF) Proteins from 3 different suppliers available. Additionally we are shipping MITF Antibodies (177) and MITF Kits (14) and many more products for this protein. A total of 205 MITF products are currently listed.
BCC2, Bhlhe32, bw, CMI9, CMM8, Gsfbcc2, LOC100313655, mi, MITF, MITF-A, MITF-H, MITF-M, mitfa, mitfb, vit, Vitiligo, Wh, WS2, WS2A
list all proteins Gene Name GeneID UniProt
MITF 4286 O75030
MITF 17342 Q08874
MITF 25094  

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MITF Proteins (MITF) by Origin

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More Proteins for MITF Interaction Partners

Horse (Equine) Microphthalmia-Associated Transcription Factor (MITF) interaction partners

  1. Accumulating mutations in series of haplotypes at the KIT and MITF loci are major determinants of white markings in Franches-Montagnes horses.

  2. several independent mutations in MITF and PAX3 (show PAX3 Proteins) together with known variants in the EDNRB (show EDNRB Proteins) and KIT genes explain a large proportion of horses with the more extreme white spotting phenotypes.

Human Microphthalmia-Associated Transcription Factor (MITF) interaction partners

  1. Data indicate that NFIB (show NFIB Proteins) protein increases EZH2 (show EZH2 Proteins) protein expression downstream of BRN2 (show POU3F2 Proteins) protein, which further decreases MITF protein levels.

  2. Overall, in melanoma lymph node metastases, MITF protein expression was not tightly correlated with its gene targets.

  3. DRD4 (show DRD4 Proteins) antagonist has an antimelanogenic effect that is related to downregulation of MITF transcription through the activation of the ERK (show EPHB2 Proteins)

  4. Akt (show AKT1 Proteins) modulates nuclear translocation of MITF.

  5. Our studies have established that the cooperative antiproliferative effects of aspirin and I3C in human melanoma cells trigger a significant downregulation of MITF-M gene expression and disruption of MITF-M promoter activity. results demonstrate that aspirin-regulated Wnt (show WNT2 Proteins) signaling and I3C-targeted signaling pathways converge at distinct DNA elements in the MITF-M promoter to cooperatively disrupt MITF-M expression

  6. Addition of MITF>/=50% into the logistic regression analysis significantly improves the accuracy of the melanoma nomogram in prediction of regional nodal spread

  7. The MITF p.E318K mutation does not appear to play a major role in sporadic renal cell carcinoma (show MOK Proteins) carcinogenesis, but is possibly restricted to a rare subpopulation of inherited renal cell carcinoma (show MOK Proteins)

  8. Immunohistochemistry using D2-40 monoclonal antibody (MAGE2) and anti-MITF1 increased detection of lymphovascular invasion in primary cutaneous melanoma.

  9. Overexpression of MITF is associated with melanoma cell survival and progression.

  10. We conclude that the expression of Rlbp1 and Rdh5 critically depends on functional Mitf in the RPE and suggest that MITF has an important role in controlling retinoid processing in the RPE.

Mouse (Murine) Microphthalmia-Associated Transcription Factor (MITF) interaction partners

  1. The suppressive activities of 7,8-DHF on melanoma progression were associated with the downregulation of microphthalmia-associated transcription factor (MITF).

  2. protein expression level of MITF and p-CREB signaling pathway are significantly increased. Moreover, 60Hz ELF-EMFs reduce the phosphorylate of ERK in B16F10 melanoma cel

  3. Microphthalmia-associated transcription factor regulates skin melanoblast migration by repressing the melanoma cell adhesion molecule (show MCAM Proteins)

  4. These findings demonstrate that LC3 (show MAP1LC3A Proteins) contributes to melanogenesis by increasing ERK (show EPHB2 Proteins)-dependent MITF expression, thereby providing a mechanistic insight into the signaling network that links autophagy to melanogenesis.

  5. the retinal degeneration associated with the disruption of the visual cycle in Mitf-deficient mice can be partially corrected both structurally and functionally by an exogenous supply of 9-cis-retina

  6. Results show that Mitf, probably including Mitf-M, is expressed in the mitral cells and tufted cells that transmit the information derived from olfactory sensory neurons to the olfactory cortex.

  7. Therefore, it is reasonable to assume that the increase in the expression of Mitf in melanocytes is involved in the age-ssociated increase in the pigmentation in the eyes of black-eyed mice.

  8. MITF interacts with BRG1 (show SMARCA4 Proteins) to promote GATA4 (show GATA4 Proteins) expression in cardiac hypertrophy.

  9. Overexpression of FHL2 (show FHL2 Proteins) alone had no effect on Erbin (show ERBB2IP Proteins) expression, but in the presence of MITF, Erbin (show ERBB2IP Proteins) expression was decreased.

  10. A reciprocal antagonism between the MITF and c-Jun (show JUN Proteins) interconnects inflammation-induced dedifferentiation with pro-inflammatory cytokine responsiveness of melanoma cells favouring myeloid cell recruitment.

Cow (Bovine) Microphthalmia-Associated Transcription Factor (MITF) interaction partners

  1. Variability in the MITF gene clearly explained the differences between spotted and non-spotted cattle phenotypes but, at the same time, it is evident that this gene is not the only genetic factor determining piebaldism in two of the studied cattle breeds.

  2. The objectives of this study were to characterize the phenotypes of German White Fleckvieh and to identify the mutation responsible for this newly detected phenotype in cattle using genome-wide association analyses and re-sequencing of MITF.

Pig (Porcine) Microphthalmia-Associated Transcription Factor (MITF) interaction partners

  1. Although MITF does not seem to be the causal gene of the QTL initially observed, it can not be excluded that a prominent role of its transcription and function in the outbreak and evolution of the tumors observed in pigs.

MITF Protein Profile

Protein Summary

This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with MITF

  • microphthalmia-associated transcription factor (MITF)
  • microphthalmia-associated transcription factor (mitf)
  • microphthalmia-associated transcription factor (LOC100313655)
  • microphthalmia-associated transcription factor (mitf-b)
  • microphthalmia-associated transcription factor (mitf-A)
  • Microphthalmia (MICROP)
  • microphthalmia-associated transcription factor (Mitf)
  • BCC2 protein
  • Bhlhe32 protein
  • bw protein
  • CMI9 protein
  • CMM8 protein
  • Gsfbcc2 protein
  • LOC100313655 protein
  • mi protein
  • MITF protein
  • MITF-A protein
  • MITF-H protein
  • MITF-M protein
  • mitfa protein
  • mitfb protein
  • vit protein
  • Vitiligo protein
  • Wh protein
  • WS2 protein
  • WS2A protein

Protein level used designations for MITF

microphthalmia transcription factor , microphthalmia-associated transcription factor , micophthalmia-associated transcription factor b , class E basic helix-loop-helix protein 32 , black eyed white , transcription factor , microphtalmia-associated transcription factor

100033918 Equus caballus
460500 Pan troglodytes
100101790 Xenopus (Silurana) tropicalis
100313655 Saccoglossus kowalevskii
100337579 Xenopus laevis
100534525 Oreochromis niloticus
100599577 Nomascus leucogenys
100532953 Ovis aries
4286 Homo sapiens
17342 Mus musculus
25094 Rattus norvegicus
407219 Bos taurus
415126 Canis lupus familiaris
395886 Gallus gallus
414902 Sus scrofa
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