Browse our MITF Proteins (MITF)

Full name:
Microphthalmia-Associated Transcription Factor Proteins (MITF)
On are 5 Microphthalmia-Associated Transcription Factor (MITF) Proteins from 3 different suppliers available. Additionally we are shipping MITF Antibodies (188) and MITF Kits (15) and many more products for this protein. A total of 217 MITF products are currently listed.
BCC2, Bhlhe32, bw, CMI9, CMM8, Gsfbcc2, LOC100313655, mi, MITF, MITF-A, MITF-H, MITF-M, mitfa, mitfb, vit, Vitiligo, Wh, WS2, WS2A
list all proteins Gene Name GeneID UniProt
MITF 4286 O75030
MITF 17342 Q08874
MITF 25094  

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MITF Proteins (MITF) by Origin

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More Proteins for MITF Interaction Partners

Horse (Equine) Microphthalmia-Associated Transcription Factor (MITF) interaction partners

  1. the missense mutation p.Arg682His, the g.77784972T>C variant at KIT and the g.20147039C>T variant at MITF are the main influence on the extent of white facial markings

  2. Accumulating mutations in series of haplotypes at the KIT and MITF loci are major determinants of white markings in Franches-Montagnes horses.

  3. several independent mutations in MITF and PAX3 (show PAX3 Proteins) together with known variants in the EDNRB (show EDNRB Proteins) and KIT genes explain a large proportion of horses with the more extreme white spotting phenotypes.

Human Microphthalmia-Associated Transcription Factor (MITF) interaction partners

  1. MITF is a direct target of miR (show MLXIP Proteins)-137.

  2. Study found in melanoma cell lines that ILEI (show FAM3C Proteins) is highly expressed in MITF-low invasive cells, and that phenotype switching between the MITF-low invasive state and the MITF-high proliferative state can alter ILEI (show FAM3C Proteins) expression.

  3. Suppression of MITF activity by UCHL1 (show UCHL1 Proteins) via protein degradation might aid in the development of new therapeutic approaches for melanoma or dyspigmentation disorders.

  4. The results of the present study have provided new and surprising insights into the effect of Bcl-2 (show BCL2 Proteins) overexpression in melanoma cells, namely that Bcl-2 (show BCL2 Proteins) modulates MITF nuclear activity.

  5. Insight into molecular interactions between CRD-BP (show IGF2BP1 Proteins) and MITF mRNA.

  6. Our data uncover novel mechanisms linking MITF-dependent inhibition of invasion to suppression of guanylate metabolism.

  7. low level of MITF cooperates with oncogenic KIT to transform melanocytes. Activation of the cAMP pathway in transformed (L576P)KIT melanocytes stimulated MITF expression, and reduced cellular proliferation and sphere formation. These findings highlight the essential role of MITF in revealing the oncogenic activity of KIT in melanocytes and suggest that the cAMP pathway is a therapeutic target in KIT-mutated melanoma.

  8. our results demonstrate that AR can promote melanoma metastasis via altering the miRNA-539-3p/USP13 (show USP13 Proteins)/MITF/AXL (show AXL Proteins) signal and targeting this newly identified signal with AR degradation enhancer ASC (show PYCARD Proteins)-J9 may help us to better suppress the melanoma metastasis.

  9. Basic functions of MITF in melanocytes and melanoma are reviewed.

  10. Our results demonstrate that MITF-E318K reduces the program of senescence to potentially favor melanoma progression in vivo.

Mouse (Murine) Microphthalmia-Associated Transcription Factor (MITF) interaction partners

  1. The association of mitochondrial microphthalmia-associated transcription factor (MITF) with pyruvate dehydrogenase (PDH (show PDP Proteins)) emerges as an important regulator of mast cell function. Our findings indicate that PDH (show PDP Proteins) could arise as a new target for the manipulation of allergic diseases.

  2. Data show that TFAP2A (show TFAP2A Proteins) binds many of the same regulatory elements as MITF in melanocytes.

  3. The suppressive activities of 7,8-DHF on melanoma progression were associated with the downregulation of microphthalmia-associated transcription factor (MITF).

  4. protein expression level of MITF and p-CREB signaling pathway are significantly increased. Moreover, 60Hz ELF-EMFs reduce the phosphorylate of ERK in B16F10 melanoma cel

  5. Microphthalmia-associated transcription factor regulates skin melanoblast migration by repressing the melanoma cell adhesion molecule (show MCAM Proteins)

  6. These findings demonstrate that LC3 (show MAP1LC3A Proteins) contributes to melanogenesis by increasing ERK (show EPHB2 Proteins)-dependent MITF expression, thereby providing a mechanistic insight into the signaling network that links autophagy to melanogenesis.

  7. the retinal degeneration associated with the disruption of the visual cycle in Mitf-deficient mice can be partially corrected both structurally and functionally by an exogenous supply of 9-cis-retina

  8. Results show that Mitf, probably including Mitf-M, is expressed in the mitral cells and tufted cells that transmit the information derived from olfactory sensory neurons to the olfactory cortex.

  9. Therefore, it is reasonable to assume that the increase in the expression of Mitf in melanocytes is involved in the age-ssociated increase in the pigmentation in the eyes of black-eyed mice.

  10. MITF interacts with BRG1 (show SMARCA4 Proteins) to promote GATA4 (show GATA4 Proteins) expression in cardiac hypertrophy.

Cow (Bovine) Microphthalmia-Associated Transcription Factor (MITF) interaction partners

  1. Variability in the MITF gene clearly explained the differences between spotted and non-spotted cattle phenotypes but, at the same time, it is evident that this gene is not the only genetic factor determining piebaldism in two of the studied cattle breeds.

  2. The objectives of this study were to characterize the phenotypes of German White Fleckvieh and to identify the mutation responsible for this newly detected phenotype in cattle using genome-wide association analyses and re-sequencing of MITF.

Pig (Porcine) Microphthalmia-Associated Transcription Factor (MITF) interaction partners

  1. Although MITF does not seem to be the causal gene of the QTL initially observed, it can not be excluded that a prominent role of its transcription and function in the outbreak and evolution of the tumors observed in pigs.

MITF Protein Profile

Protein Summary

This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with MITF

  • microphthalmia-associated transcription factor (MITF)
  • microphthalmia-associated transcription factor (mitf)
  • microphthalmia-associated transcription factor (LOC100313655)
  • microphthalmia-associated transcription factor (mitf-b)
  • microphthalmia-associated transcription factor (mitf-A)
  • Microphthalmia (MICROP)
  • microphthalmia-associated transcription factor (Mitf)
  • BCC2 protein
  • Bhlhe32 protein
  • bw protein
  • CMI9 protein
  • CMM8 protein
  • Gsfbcc2 protein
  • LOC100313655 protein
  • mi protein
  • MITF protein
  • MITF-A protein
  • MITF-H protein
  • MITF-M protein
  • mitfa protein
  • mitfb protein
  • vit protein
  • Vitiligo protein
  • Wh protein
  • WS2 protein
  • WS2A protein

Protein level used designations for MITF

microphthalmia transcription factor , microphthalmia-associated transcription factor , micophthalmia-associated transcription factor b , class E basic helix-loop-helix protein 32 , black eyed white , transcription factor , microphtalmia-associated transcription factor

100033918 Equus caballus
460500 Pan troglodytes
100101790 Xenopus (Silurana) tropicalis
100313655 Saccoglossus kowalevskii
100337579 Xenopus laevis
100534525 Oreochromis niloticus
100599577 Nomascus leucogenys
100532953 Ovis aries
4286 Homo sapiens
17342 Mus musculus
25094 Rattus norvegicus
407219 Bos taurus
415126 Canis lupus familiaris
395886 Gallus gallus
414902 Sus scrofa
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