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In combination testing, MKRN1 + HPV showed the highest sensitivity and specificity levels. The MKRN1 biomarker may be a useful adjunct in primary cervical cytology screening.
EGFR (show EGFR Proteins)/PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)-mediated ubiquitination and degradation of PTEN are dependent on the MKRN1 E3 ligase.
Results verified MKRN1 as an ubiquitin E3 ligase of p14ARF, it potentially regulates cellular aging and tumorigenesis in gastric cancer.
MKRN1 could induce WNV capsid protein ubiquitination and degradation in a proteasome-dependent manner
MKRN1 may represent a nuclear protein with multiple nuclear functions, including regulating RNA polymerase II-catalyzed transcription.
Data indicate that MKRN1 is a novel modulator of p53 (show TP53 Proteins) and p21 (show CDKN1A Proteins), preferentially leading cells to p53 (show TP53 Proteins)-dependent apoptosis by suppressing p21 (show CDKN1A Proteins).
Makorin 1 is a novel SEREX antigen of esophageal squamous cell carcinoma
Systems-level analyses support a role for the E3 ligase MKRN1 as a ribonucleoprotein within the embryonic stem cell gene regulatory network
MKRN1 is an elusive PPARgamma (show PPARG Proteins) E3 ligase that targets PPARgamma (show PPARG Proteins) for proteasomal degradation by ubiquitin-dependent pathways, and further depict MKRN1 as a novel target for diseases involving PPARgamma (show PPARG Proteins).
Mutagenesis reduces transcription of Makorin1-pseudogene, resulting in destabilization of Makorin1 mRNA in trans by way of a cis (show CISH Proteins)-acting RNA decay element within the 5' region of Makorin1 that is homologous between Makorin1 and Makorin1-pseudogene
Mkrn1-p1 is not imprinted, and neither it or its source Mkrn1 gene relates to the original imprinted transgene phenotype
The Makorin ring finger protein-1 gene (MKRN1) is a highly transcribed, intron-containing source for a family of intronless mammalian genes encoding a novel class of zinc finger proteins. Phylogenetic analyses indicate that the MKRN1 gene is the ancestral founder of this gene family (Gray et al., 2000
makorin ring finger protein 1
, makorin, ring finger protein, 1
, E3 ubiquitin-protein ligase makorin-1-like
, e3 ubiquitin-protein ligase makorin-1-like
, MGC84269 protein
, makorin 1
, E3 ubiquitin-protein ligase makorin-1
, RING finger protein 61