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An in vivo genetic reversion highlights the crucial role of MYSM1 in human hematopoiesis and lymphocyte differentiation
the biallelic truncation of MYSM1 likely represents the cause of an inherited bone marrow failure syndrome in two siblings
The SWIRM structure of human MYb (show MYB Proteins)-like, Swirm and Mpn domain-containing protein (show MPND Proteins)-1 (MYSM1), is reported.
The identification of histone H2A deubiquitinase (2A-DUB, or KIAA1915/MYSM1) specific for monoubiquitinated H2A (uH2A) that helps in delineating a strategy for specific regulatory pathways of gene activation, is reported.
The results demonstrate that MYSM1 plays a critical role in Mesenchymal Stromal Cell maintenance and differentiation. This study also underscores the biological significance of deubiquitinase activity in Mesenchymal Stromal Cell function.
MYSM1 is a critical negative regulator of p53 (show TP53 Proteins) transcriptional programs in hematopoiesis, and its repression of Bbc3/PUMA (show BBC3 Proteins) expression is essential for multipotent progenitor survival, and partly contributes to maintaining hematopoietic stem cell function
this study uncovers a critical role for MYSM1 in epigenetically repressing plasma cell differentiation and antibody production, in addition to its opposing, active role in B cell development.
MYSM1 is essential for normal HSC (show FUT1 Proteins) function and progression of hematopoiesis in the fetal liver and HSC (show FUT1 Proteins) maintenance in adult bone marrow.
2 motifs in MYSM1 are essential for innate immune suppression: the SWIRM domain that interacts with TRAF3 (show TRAF3 Proteins) and TRAF6 (show TRAF6 Proteins) and the metalloproteinase domain that removed K63 polyubiquitins. MYSM1 is a key negative regulator of the innate immune system
Loss of hematopoietic stem cell function and bone marrow failure in Mysm1-knockout mice are the result of p53 (show TP53 Proteins) activation.
Data indicate that histone H2A deubiquitinase Mysm1 is required for dendritic cell development.
Mysm1-mediated epigenetic regulation has a role in controlling hematopoietic stem cell maintenance, self-renewal, and differentiation
MYSM1 is required for natural killer cell maturation, including the the recruitment of nuclear factor Il-3 to the ID2 locus.
Data indicate a role for histone H2A-deubiquitinase Mysm1 in the maintenance of bone marrow stem cell function, in the control of oxidative stress and genetic stability in hematopoietic progenitors.
Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation (By similarity).
histone H2A deubiquitinase MYSM1
, myb-like, SWIRM and MPN domain-containing protein 1
, Myb-like, SWIRM and MPN domain-containing protein 1