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This study reports on the prevalence of RAG1 (show RAG1 ELISA Kits) and RAG2 mutations in ten severe combined immunodeficiency (show PRKDC ELISA Kits) disorder patients in Egypt.
analysis of regions of RAG1 (show RAG1 ELISA Kits) necessary for interaction with RAG2 and measurement of the RAG1 (show RAG1 ELISA Kits)-RAG2 binding affinity
DNA damage triggers relocalization of RAG2 from the nucleus to centrosomes, suggesting a novel mechanism for modulating cellular responses to double strand breaks in developing lymphocytes.
found that Ikaros (show IKZF1 ELISA Kits), a lymphocyte-specific transcription factor, acts as a repressor of NWC promoter--thus identifying a new Ikaros (show IKZF1 ELISA Kits) target--but is insufficient for inducing methylation which depends on the antisense transcription driven by RAG-2 promoter
Investigate the factors that regulate RAG1 (show RAG1 ELISA Kits) and RAG2 cleavage on non-B DNA structures. We find that RAG binding and cleavage on heteroduplex DNA is dependent on the length of the double-stranded flanking region.
The results indicate that the contribution of immune dysregulatory disease due to RAG2 mutations present in the general population may be much higher than previously estimated.
The major B cell isoform, BCL11A-XL (show BCL11A ELISA Kits), binds the RAG1 (show RAG1 ELISA Kits) promoter and Erag enhancer to activate RAG1 (show RAG1 ELISA Kits) and RAG2 transcription in pre-B cells.
Bidirectional activity of the NWC promoter is responsible for RAG-2 transcription in non-lymphoid cells
A novel homozygous mutation with different clinical phenotypes: Omenn syndrome and hyper-IgM syndrome
analysis of multiorgan metastasis of human HER-2 (show ERBB2 ELISA Kits)+ breast cancer in Rag2-/-;Il2rg (show IL2RG ELISA Kits)-/- mice and treatment with PI3K (show PIK3CA ELISA Kits) inhibitor
the zinc finger motif within the noncore region of RAG2 is indispensable for maintaining the stability of the RAG2 protein.
evolution of RAG1 (show RAG1 ELISA Kits)/RAG2 began with a Transib transposon whose intrinsic recombination activity was enhanced by capture of an ancestral RAG2, allowing for the development of adaptive immunity.
Rag2(R229Q) knock-in mice developed an inflammatory bowel disease affecting both the small bowel and colon.
Rag2 truncation substantially increased the frequency of off-target V(D)J recombination. The data suggest that interactions between Rag2 and a specific chromatin modification, H3K4me3, support V(D)J recombination fidelity.
These results reveal an unanticipated functional interplay between the RAG complex and XLF (show NHEJ1 ELISA Kits) in repairing RAG-induced DNA breaks and maintaining genome integrity during antigen receptor gene assembly.
Based on our results, we propose that interaction of RAG2 with RAG1 (show RAG1 ELISA Kits) induces cooperative interactions of multiple binding sites, induced through conformational changes at the RAG1 (show RAG1 ELISA Kits) interdomain boundary
12recombination signal sequences-23recombination signal sequences cooperation (the "12/23 rule") is important not only for regulating RAG-mediated DNA cleavage but also for the efficiency of RAG1 (show RAG1 ELISA Kits) and RAG2 recruitment to chromatin.
This study demonstrated that The behavioral impairments in Rag2(-/-) mice were paralleled by an elevation in plasma corticosterone after behavioral tests.
We have confirmed the activation of human peripheral blood lymphocytes after being xenografted in immunodeficient Rag2-/-IL2Rgnull mice.
V(D)J recombination is stimulated by binding of H3K4me3 to RAG-2
Produced RAG2-knockouts via somatic cell nuclear transfer and analyzed their phenotype. The V(D)J recombination processes were confirmed as being inactivated. They consistently lacked mature T and B cells but had substantial numbers of cells considered to be T- or B-cell progenitors as well as NK cells. They also lacked thymic medulla and lymphoid aggregations in the spleen, mesenteric lymph nodes, and Peyer's patches.
Homozygous RAG1 (show RAG1 ELISA Kits)/2 knockout pigs lack mature B and T lymphocytes; recombination does not occur in the Ig heavy chain (IgH) locus of RAG1 (show RAG1 ELISA Kits)- and RAG2-deficient pigs.
created rag2(E450fs) mutant zebrafish that have reduced numbers of functional T and B cells but are viable and fecund
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
recombination activating gene 2
, recombination activating protein 2
, V(D)J recombination-activating protein 2-like
, V(D)J recombination-activating protein 2
, recombinase activating gene 2
, v(D)J recombination-activating protein 2