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Browse our anti-RECQL4 (RECQL4) Antibodies

Full name:
anti-RecQ Protein-Like 4 Antibodies (RECQL4)
On www.antibodies-online.com are 37 RecQ Protein-Like 4 (RECQL4) Antibodies from 12 different suppliers available. Additionally we are shipping RECQL4 Proteins (3) and many more products for this protein. A total of 45 RECQL4 products are currently listed.
Synonyms:
MGC145453, RECQ4, RTS, xrecq4
list all antibodies Gene Name GeneID UniProt
RECQL4 300057  
RECQL4 9401 O94761
RECQL4 79456 Q75NR7

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Most Popular Reactivities for anti-RECQL4 (RECQL4) Antibodies

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anti-Rat (Rattus) RECQL4 Antibodies:

anti-Human RECQL4 Antibodies:

anti-Mouse (Murine) RECQL4 Antibodies:

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Top referenced anti-RECQL4 Antibodies

  1. Human Polyclonal RECQL4 Primary Antibody for WB - ABIN1881738 : Rossi, Ghosh, Kulikowicz, Croteau, Bohr: Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding. in DNA repair 2010 (PubMed)
    Show all 5 references for ABIN1881738

  2. Human Monoclonal RECQL4 Primary Antibody for IHC (p), ELISA - ABIN522857 : Lao, Welcsh, Luo, Carter, Dzieciatkowski, Dintzis, Meza, Sarvetnick, Monnat, Loeb, Grady: Altered RECQ Helicase Expression in Sporadic Primary Colorectal Cancers. in Translational oncology 2013 (PubMed)

More Antibodies against RECQL4 Interaction Partners

Xenopus laevis RecQ Protein-Like 4 (RECQL4) interaction partners

  1. RecQ4 plays an important role in the conversion of pre-initiation complexes into active replisomes requiring the unwinding of origin DNA in vertebrates.

  2. RecQL4 is loaded adjacent to Ku heterodimer-binding sites on damaged chromatin, and functions in the repair of double-stranded DNA breaks.

  3. RecQ4 performs an essential role in the assembly of replication machinery through interaction with Cut5 (show TOPBP1 Antibodies) in vertebrates.

Human RecQ Protein-Like 4 (RECQL4) interaction partners

  1. this study demonstrates for the first time that, owing to its mitochondrial functions, the accessory mitochondrial replication helicase RECQL4 prevents the invasive step in the neoplastic transformation process.

  2. These results reveal novel possible roles of RecQ4 in DNA replication and genome stability.

  3. RECQL4 is tumour promoting in established breast cancers

  4. RecQL4-dependent association of Mcm10 (show MCM10 Antibodies) and Ctf4 (show WDHD1 Antibodies) with replication origins appears to be the first important step controlled by S phase promoting kinases and checkpoint pathways for the initiation of DNA replication in human cells.

  5. No RECQL4 mutations were found in the BGS group without poikiloderma, confirming that RECQL4 sequencing was not indicated in this phenotype.

  6. This finding provided the key to unravel the correlation between the RECQL4 genotype and the mild phenotype of the two siblings of Rothmund-Thomson Syndrome.

  7. The N-terminus of human RecQL4 acts as a complex moderator of DNA transactions that are mediated by multiple DNA-binding sites.

  8. RECQL4 stimulates higher order DNA binding of Ku70 (show XRCC6 Antibodies)/Ku80 (show XRCC5 Antibodies) to a blunt end DNA substrate. Taken together, these results implicate that RECQL4 participates in the NHEJ pathway of DSB repair via a functional interaction with the Ku70 (show XRCC6 Antibodies)/Ku80 (show XRCC5 Antibodies) complex.

  9. The highly cancer-prone RECQ4 ID mutant failed to interact with p32, leading to increases in mtDNA copy number and MT dysfunction.

  10. Dysfunction of RECQL4 increases DNA damage and triggers premature senescence in both human and mouse cells, which may contribute to symptoms in Rothmund-Thompson syndrome patients.

Mouse (Murine) RecQ Protein-Like 4 (RECQL4) interaction partners

  1. RECQL4 is essential for normal bone development. Animals with no Recql4 in bone cells did not develop osteosarcoma.

  2. findings show that RECQL4 is critical for skeletal development by modulating p53 (show TP53 Antibodies) activity in vivo.

  3. data indicate that RECQL4 participates in DNA replication rather than genome stability and identify RECQL4 as a regulator of hematopoiesis with a nonredundant role compared with other RecQ helicases

  4. dysfunction of RECQL4 increases DNA damage and triggers premature senescence in both human and mouse cells, which may contribute to Rothmund-Thomson syndrome features in mice.

  5. Elevated expression of RECQL4 accompanies progression of the Rothmund-Thomson Syndrome into osteosarcoma in humans and mice.

  6. Recql4-deficient mice show growth retardation and skin abnormalities.

  7. Recql4 functions as a regulatory protein during osteoprogenitor proliferation, a critical cellular event during skeleton development.

  8. we define a small core bidirectional promoter that drives expression of the mouse genes Recql4, on one strand, and Lrrc14 (show LRRC14 Antibodies); a novel member of the LRR gene family, on the opposite strand

RECQL4 Antigen Profile

Antigen Summary

The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes.

Alternative names and synonyms associated with RECQL4

  • RecQ protein-like 4 (Recql4) antibody
  • RecQ protein-like 4 (RECQL4) antibody
  • RecQ protein-like 4 (recql4) antibody
  • MGC145453 antibody
  • RECQ4 antibody
  • RTS antibody
  • xrecq4 antibody

Protein level used designations for RECQL4

ATP-dependent DNA helicase Q4 , RecQ protein-like 4 , ATP-dependent DNA helicase Q4-like , DNA helicase, RecQ-like type 4 , DNA helicase, RecQ-like, type 4 , RecQ helicase protein-like 4

GENE ID SPECIES
300057 Rattus norvegicus
429982 Gallus gallus
464469 Pan troglodytes
482101 Canis lupus familiaris
515472 Bos taurus
703354 Macaca mulatta
734225 Xenopus laevis
780344 Xenopus (Silurana) tropicalis
100399025 Callithrix jacchus
100456857 Pongo abelii
100477071 Ailuropoda melanoleuca
100064627 Equus caballus
9401 Homo sapiens
79456 Mus musculus
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