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Deficiency of ADA2 causes IgA-IgG antibody deficiencies in a family.
results thus demonstrate that the catalytic activity of GCN5 (show KAT2A ELISA Kits) is stimulated by subunits of the ADA2a- or ADA2b-containing HAT (show MGEA5 ELISA Kits) modules and is further increased by incorporation of the distinct HAT (show MGEA5 ELISA Kits) modules in the ATAC (show XCL1 ELISA Kits) or SAGA holo-complexes
Single nucleotide polymorphism in ADA2 gene is associated with type 1 diabetes.
CCDC134 increased the PCAF (show KAT2B ELISA Kits)-dependent K320 acetylation of p53 (show TP53 ELISA Kits) and p53 (show TP53 ELISA Kits) protein stability in the presence of hADA2a overexpression.
hADA2a and hADA3 (show TADA3 ELISA Kits) as crucial cofactors of beta-catenin (show CTNNB1 ELISA Kits) that are likely involved in the assembly of transactivation-competent beta-catenin (show CTNNB1 ELISA Kits) complexes at Wnt (show WNT2 ELISA Kits) target genes.
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined.
transcriptional adaptor 2A
, transcriptional adaptor 2 (ADA2 homolog, yeast)-like
, transcriptional adapter 2-alpha-like
, ADA2-like protein
, transcriptional adapter 2-alpha
, transcriptional adaptor 2 alpha