Browse our C1S Proteins (C1S)

Full name:
Complement Component 1, S Subcomponent Proteins (C1S)
On are 11 Complement Component 1, S Subcomponent (C1S) Proteins from 6 different suppliers available. Additionally we are shipping C1S Antibodies (81) and C1S Kits (17) and many more products for this protein. A total of 114 C1S products are currently listed.
AA959438, AI255193, AI327365, C1S, C1sa, r-gsp
list all proteins Gene Name GeneID UniProt
C1S 716 P09871
C1S 192262 Q6P6T1
C1S 50908 Q8CG14

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C1S Proteins (C1S) by Origin

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Human Complement Component 1, S Subcomponent (C1S) interaction partners

  1. Periodontal Ehlers-Danlos Syndrome in at least the great majority of cases results from specific classes of heterozygous mutations in C1R (show C1R Proteins) and C1S.

  2. C1q exists as the C1 complex (C1qC1r2C1s2), and C1q binding to ligands activates the C1r (show C1R Proteins)/C1s proteases. Incubation of nucleoli with C1 caused degradation of the nucleolar proteins nucleolin (show NCL Proteins) and nucleophosmin 1 (show NPM1 Proteins). T

  3. Data indicate that complement C1s mRNA level was low in ICR-derived glomerulonephritis (ICGN) mice liver as compared with age-matched ICR mice.

  4. Analysis of its interaction properties by surface plasmon resonance shows that rC1q retains the ability of serum C1q to associate with the C1s-C1r-C1r (show C1R Proteins)-C1s tetramer, to recognize physiological C1q ligands such as IgG and pentraxin 3 (show PTX3 Proteins)

  5. A molecular switch governs the interaction between the human complement protease C1s and its substrate, complement C4.

  6. Four positively charged amino acids on the serine protease (show F2 Proteins) domain appear to form a catalytic exosite that is required for efficient cleavage of C4 in the classical pathway of complement.

  7. These results provide further structural insights into the architecture of the C1 complex, and the interactions between C1r (show C1R Proteins) and C1s.

  8. Detailed mapping of post-translational modifications and insights into the C1r (show C1R Proteins)/C1s binding sites.

  9. Interaction with the prime side residues at the cleavage point in C1s enhances the affinity of the enzyme for complement 2 and complement 4 substrates; these prime subsite residues mediate positive cooperativity in the cleavage of the substrate.

  10. There are splice variants of C1s mRNA transcripts in normal human cells

Mouse (Murine) Complement Component 1, S Subcomponent (C1S) interaction partners

  1. C1r (show C1RA Proteins) and this gene are duplicated in mice; differential expression generates alternative isomorphs in the liver and in the male reproductive system.

C1S Protein Profile

Protein Summary

This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency.

Alternative names and synonyms associated with C1S

  • complement component 1, s subcomponent (C1S)
  • complement component 1, s subcomponent (c1s)
  • complement component 1, s subcomponent (LOC100222051)
  • complement component 1, s subcomponent (C1s)
  • AA959438 protein
  • AI255193 protein
  • AI327365 protein
  • C1S protein
  • C1sa protein
  • r-gsp protein

Protein level used designations for C1S

C1 esterase , complement C1s subcomponent , complement component 1 subcomponent s , complement component C1s , complement component 1, s subcomponent , complement C1s subcomponent-like , basic proline-rich peptide IB-1 , complement C1s-A subcomponent , complement component 1 subcomponent s-A , complement component C1SA , serine protease

397274 Sus scrofa
418294 Gallus gallus
451808 Pan troglodytes
613055 Xenopus (Silurana) tropicalis
714589 Macaca mulatta
722136 Macaca mulatta
733422 Xenopus laevis
100222051 Taeniopygia guttata
100412274 Callithrix jacchus
100455685 Pongo abelii
100549400 Meleagris gallopavo
100558615 Anolis carolinensis
100599399 Nomascus leucogenys
716 Homo sapiens
192262 Rattus norvegicus
767827 Bos taurus
486714 Canis lupus familiaris
50908 Mus musculus
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