Browse our C3 Proteins (C3)

Full name:
Complement Component 3 Proteins (C3)
On are 42 Complement Component 3 (C3) Proteins from 8 different suppliers available. Additionally we are shipping C3 Antibodies (384) and C3 Kits (113) and many more products for this protein. A total of 543 C3 products are currently listed.
AHUS5, AI255234, ARMD9, ASP, c3, C3-1, C3a, C3b, C3d, c3_D, CPAMD1, HSE-MSF, Plp, sb:cb26, si:dkey-76b14.4, wu:fi34b03, wu:fj86e11
list all proteins Gene Name GeneID UniProt
C3 12266 P01027
C3 718 P01024
C3 24232 P01026

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C3 Proteins (C3) by Origin

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More Proteins for C3 Interaction Partners

Zebrafish Complement Component 3 (C3) interaction partners

  1. Neural crest cells are coattracted via the complement fragment C3a and its receptor C3aR (show C3AR1 Proteins), revealing an unexpected role of complement proteins in early vertebrate development.

Mouse (Murine) Complement Component 3 (C3) interaction partners

  1. Retinal C3 was expressed by microglia/macrophages located in the outer retina in AMD (show AMD1 Proteins) eyes. In rodent photo-oxidative damage, C3-expressing microglia/macrophages and complement activation were located in regions of lesion expansion in the outer retina over 2 months

  2. Demonstrate local synthesis of complement proteins by both PDGFRbeta-positive pericytes and CD45 (show PTPRC Proteins)-positive cells in kidney fibrosis.

  3. Wild-type C57BL/6 mice with pristane-induced lupus developed a strong IFN signature, which was absent in immunoglobulin-deficient (muMT), C3(-/-) , and CD18 (show ITGB2 Proteins)(-/-) mice. In vivo phagocytosis of dead cells was impaired in C3-deficient mice.

  4. Study found that cancer-cell-derived C3 activates the C3a receptor in the choroid plexus epithelium to disrupt the blood-cerebrospinal fluid (CSF (show CSF2 Proteins)) barrier. This effect allows plasma components, including amphiregulin (show AREG Proteins), and other mitogens to enter the CSF (show CSF2 Proteins) and promote cancer cell growth.

  5. We induced anti-myeloperoxidase (show MPO Proteins) vasculitis in mice and confirmed a role for complement activation by demonstrating protection in C3-deficient mice.

  6. These data indicated that alpha7-nAChR (show CHRNA7 Proteins) caused the inhibition of ASPinduced activation of p38 (show CRK Proteins) kinase and NFkappa B to inhibit the production of MCP1 (show CCL2 Proteins) and keratinocytederived chemokine (show CCL1 Proteins).

  7. This study provideed the evidence that C3a plays a critical role in cerebral endothelial activation and leukocyte recruitment during inflammation in the brain.

  8. Demonstrate that cardiac Sirt1 (show SIRT1 Proteins) plays an essential role in caloritc restriction-induced cardioprotection against myocardial I/R injury by suppressing cardiac C3 expression.

  9. The roles of C3, CfB (show CFB Proteins), and C3a receptor in the severity of S. aureus induced septic arthritis are reported.

  10. Study shows that C3a is locally produced by -retinal pigment epithelial cells suggesting a key role in early macular degenerations pathogenesis.

Human Complement Component 3 (C3) interaction partners

  1. The uromodulin (show UMOD Proteins)-CFH (show CFH Proteins) interaction enhanced the cofactor activity of CFH (show CFH Proteins) for factor I-mediated cleavage of C3b to inactivated C3b.

  2. Generated monoclonal antibody that can only bind to C3d when it manifests itself as the final end product of cleaved C3.

  3. C3 was strongly associated with insulin (show INS Proteins) sensitivity after bariatric surgery.

  4. human neutrophil peptides 1-3 and complement activation fragments iC3b were higher in patients with acute thrombotic thrombocytopenic purpura - indicating a role of innate immunity in acute autoimmune TTP (show ADAMTS13 Proteins).

  5. CFH (show CFH Proteins), ARMS2 (show ARMS2 Proteins), and C3 were associated with specific features of neovascularization at the time patients were enrolled in Comparison of Age-Related Macular Degeneration Treatments Trials .

  6. Neutralization of the complement factor C3-dependent antichlamydial activity was dependent on the proteolytic activity of Chlamydia trachomatis CPAF and correlated with the CPAF-mediated degradation of complement factor C3 and factor B (show ATP5S Proteins).

  7. Elevated C3a is able to predict the mortality following cardiac resynchronization therapy of heart failure

  8. Cerebrospinal fluid (CSF (show CSF2 Proteins)) soluble complement receptor 2 (sCR2 (show RBMS1 Proteins)) levels correlated significantly both with CSF (show CSF2 Proteins) complements C3 and C1q as well as to a disease severity measure.

  9. this paper shows that chymase (show CMA1 Proteins) may control C3-related pathology in cutaneous vasculitis

  10. The present data provided evidence that reducing C3 activation can decreases VEGF (show VEGFA Proteins) and increase PEDF (show SERPINF1 Proteins) mRNA level in retinal pigment epithelial cells.

Cow (Bovine) Complement Component 3 (C3) interaction partners

Xenopus laevis Complement Component 3 (C3) interaction partners

  1. Neural crest cells are coattracted via the complement fragment C3a and its receptor C3aR (show C3AR1 Proteins), revealing an unexpected role of complement proteins in early vertebrate development.

C3 Protein Profile

Protein Summary

Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection.

Alternative names and synonyms associated with C3

  • complement component c3a (c3a)
  • complement component 3 (C3)
  • complement component 3 (c3)
  • complement C3-like (LOC100060539)
  • complement component C3 (c3-1)
  • endogenous retrovirus group K, member 13 (ERVK-13)
  • AHUS5 protein
  • AI255234 protein
  • ARMD9 protein
  • ASP protein
  • c3 protein
  • C3-1 protein
  • C3a protein
  • C3b protein
  • C3d protein
  • c3_D protein
  • CPAMD1 protein
  • HSE-MSF protein
  • Plp protein
  • sb:cb26 protein
  • si:dkey-76b14.4 protein
  • wu:fi34b03 protein
  • wu:fj86e11 protein

Protein level used designations for Complement Component 3 Proteins (C3)

cb26 , complement component 3 , acylation stimulating protein , complement C3 , complement component 3d , complement factor 3 , C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 , C3a anaphylatoxin , acylation-stimulating protein cleavage product , complement component C3 , complement component C3a , complement component C3b , prepro-C3 , complement C3 alpha chain , complement component C3d

321046 Danio rerio
455644 Pan troglodytes
703613 Macaca mulatta
100216255 Xenopus (Silurana) tropicalis
100060539 Equus caballus
12266 Mus musculus
100135462 Cavia porcellus
718 Homo sapiens
24232 Rattus norvegicus
397072 Sus scrofa
280677 Bos taurus
100009121 Oryctolagus cuniculus
476728 Canis lupus familiaris
396370 Gallus gallus
443475 Ovis aries
398666 Xenopus laevis
100136951 Oncorhynchus mykiss
100861467 Homo sapiens
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