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anti-Rat (Rattus) C5A Antibodies:
anti-Human C5A Antibodies:
anti-Mouse (Murine) C5A Antibodies:
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Mouse (Murine) Monoclonal C5A Primary Antibody for ELISA - ABIN2688862
Hugli: Structure and function of the anaphylatoxins. in Springer seminars in immunopathology 1984
Studies indicate that the complement response lie the active fragments, C3a (show C3 Antibodies) and C5a, acting through their specific receptors, C3aR (show C3AR1 Antibodies), C5aR1 (show C5AR1 Antibodies) and C5aR2 to direct the cellular response to inflammation.
Data show the expression of a neoepitope which was exposed on complement C5 (show C5 Antibodies) (C5) after binding to eculizumab in vivo.
TLR4 (show TLR4 Antibodies) and C5aR (show C5AR1 Antibodies) crosstalk in dendritic cells induces a core regulatory network of RSK2 (show RPS6KA3 Antibodies), PI3Kbeta, SGK1 (show SGK1 Antibodies), and FOXO (show FOXO3 Antibodies) transcription factors.
data indicate that properdin enhances platelet/granulocyte aggregates (PGAs) formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation
Increased C5a expression is associated with increased inflammation in cystic fibrosis (show S100A8 Antibodies).
Results showed that 7-oxygenated cholesterol derivatives have differential effects on monocyte/macrophage expression of IL-8 (show IL8 Antibodies) and C5a receptor and that C5a receptor is involved in 7alphaOHChol-induced IL-8 (show IL8 Antibodies) expression via PI3K (show PIK3CA Antibodies) and MEK (show MAP2K1 Antibodies). Study demonstrated expression of IL-8 (show IL8 Antibodies) and C5a receptor primarily by 7alpha-hydroxycholesterol in monocytes/macrophages.
Reducing RPS19 (show RPS19 Antibodies) in tumor cells or blocking the C5a receptor 1-RPS19 (show RPS19 Antibodies) interaction decreases RPS19 (show RPS19 Antibodies)-mediated immunosuppression, impairs tumor growth, and delays the development of tumors in a transgenic model of breast cancer
C5aR (show C5AR1 Antibodies) expression in gastric cancer was associated with cancer progression, liver metastasis, and poor prognosis.
this study shows that downregulation of CD88 (show C5AR1 Antibodies) after stimulation with IL-8 (show IL8 Antibodies) is more pronounced in adults than in neonates, whereas fMLP (show FPR1 Antibodies) induces changes in receptor expression that are of the same magnitude in neutrophils from neonates as from adults
C5a in vitro caused activation (phosphorylation) of MAPKs and Akt (show AKT1 Antibodies) in cardiomyocytes, which required availability of both C5a receptors. These data suggest that polymicrobial sepsis causes cardiac dysfunction that appears to be linked to activation of MAPKs and Akt (show AKT1 Antibodies) in heart.
n the complex but clinically relevant DH model the local and systemic inflammatory immune response features both, C5-dependent and C5-independent characteristics. Activation of caspase-3 (show CASP3 Antibodies) in lung tissue after DH was C5-dependent whereas local inflammation in lung tissue was C5-independent.
The C5a/C5aR pathway is essential for up-regulating SphK1 (show SPHK1 Antibodies) expression through p38 MAPK (show MAPK14 Antibodies) activation in acute liver failure.in mice.
We induced anti-myeloperoxidase (show MPO Antibodies) vasculitis in bone marrow chimaeric mice and found that circulating and not bone marrow-derived C5 was required for disease
Choroidal neovascularization lesions trigger a systemic immune response, augmenting local ocular inflammation via the infiltration of IL-17 (show IL17A Antibodies)-producing gamma-delta T-cells, which are presumably recruited to the eye in a C5a-dependent manner.
Data (including data from studies in knockout mice) suggest that C5aR/C5aR (show C5AR1 Antibodies) (complement C5a/anaphylatoxin (show C5 Antibodies) C5a Receptor) signaling pathway is involved in neurocognitive injury in uninfected pups induced by malaria in pregnancy.
Carboxypeptidase B2 (show CPB2 Antibodies) deficiency reveals that complement C5a exacerbates infection in a murine polymicrobial sepsis model.
our results suggest that the detrimental effects of C5a in this model are partly mediated through CCR5 activation downstream of C5aR1 (show C5AR1 Antibodies), which may be evaluated for potential therapeutic exploitation in ALI/ARDS.
C5a signaling increases the expression of the chemokine (show CCL1 Antibodies) monocyte chemoattractant protein-1 (show CCL2 Antibodies) in hepatic metastases of colon cancer
Properdin (show CFB Antibodies) provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6 (show IL6 Antibodies)-dependent manner.
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
, complement C5
, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
, C5a anaphylatoxin
, anaphylatoxin C5a analog
, C5a anaphylatoxin chemotactic receptor 1
, C5a anaphylatoxin receptor
, C5a ligand
, complement component 5 receptor 1