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Human C5A ELISA Kit for Sandwich ELISA - ABIN414444
Denny, Coulthard, Finnell, Callaway, Taylor, Woodruff: Elevated complement factor C5a in maternal and umbilical cord plasma in preeclampsia. in Journal of reproductive immunology 2013
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Rat (Rattus) C5A ELISA Kit for Sandwich ELISA - ABIN416133
Recknagel, Bindl, Wehner, Göckelmann, Wehrle, Gebhard, Huber-Lang, Claes, Ignatius: Conversion from external fixator to intramedullary nail causes a second hit and impairs fracture healing in a severe trauma model. in Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2013
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Human C5A ELISA Kit for Sandwich ELISA - ABIN2690553
Bokisch, Müller-Eberhard: Anaphylatoxin inactivator of human plasma: its isolation and characterization as a carboxypeptidase. in The Journal of clinical investigation 1971
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Mouse (Murine) C5A ELISA Kit for Sandwich ELISA - ABIN415414
Woehrl, Brouwer, Murr, Heckenberg, Baas, Pfister, Zwinderman, Morgan, Barnum, van der Ende, Koedel, van de Beek: Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis. in The Journal of clinical investigation 2011
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Mouse (Murine) C5A ELISA Kit for Sandwich ELISA - ABIN1979368
Kang, Tsolmon, Mann, Zheng, Zhao, Zhao, Volk, Lokesh, Morris, Gupta, Razaq, Rui, Suh, Gorenstein, Tanaka: Safety evaluation of intravenously administered mono-thioated aptamer against E-selectin in mice. in Toxicology and applied pharmacology 2015
Mouse (Murine) C5A ELISA Kit for Sandwich ELISA - ABIN366388
Tang, Xue, Yan, Xiang, Sun, Zhao: Heparin-like surface modification of polyethersulfone membrane and its biocompatibility. in Journal of colloid and interface science 2012
Human C5A ELISA Kit for Sandwich ELISA - ABIN365042
Nie, Ma, Cheng, Deng, Zhao: Nanofibrous heparin and heparin-mimicking multilayers as highly effective endothelialization and antithrombogenic coatings. in Biomacromolecules 2015
Human C5A ELISA Kit for Sandwich ELISA - ABIN1114348
Wu, Wang, Qin, Wang, Wang, Yang, Zheng, Wang: CD55 limits sensitivity to complement-dependent cytolysis triggered by heterologous expression of ?-gal xenoantigen in colon tumor cells. in American journal of physiology. Gastrointestinal and liver physiology 2014
C5aR (show C5AR1 ELISA Kits) plays a role in T helper cell polarization induced by Mycobacterium tuberculosis and this effect is strain- and donor-dependent.
Panton-Valentine leucotoxin LukS-PV/LukF-PV and the gamma-hemolysin (show PLC ELISA Kits) HlgC/HlgB, bind the C5a complement-derived peptide receptor, inducing intracellular calcium release in neutrophils.
Studies indicate that the complement response lie the active fragments, C3a (show C3 ELISA Kits) and C5a, acting through their specific receptors, C3aR (show C3AR1 ELISA Kits), C5aR1 (show C5AR1 ELISA Kits) and C5aR2 to direct the cellular response to inflammation.
Data show the expression of a neoepitope which was exposed on complement C5 (show C5 ELISA Kits) (C5) after binding to eculizumab in vivo.
TLR4 (show TLR4 ELISA Kits) and C5aR (show C5AR1 ELISA Kits) crosstalk in dendritic cells induces a core regulatory network of RSK2 (show RPS6KA3 ELISA Kits), PI3Kbeta, SGK1 (show SGK1 ELISA Kits), and FOXO (show FOXO3 ELISA Kits) transcription factors.
data indicate that properdin enhances platelet/granulocyte aggregates (PGAs) formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation
Increased C5a expression is associated with increased inflammation in cystic fibrosis (show S100A8 ELISA Kits).
Results showed that 7-oxygenated cholesterol derivatives have differential effects on monocyte/macrophage expression of IL-8 (show IL8 ELISA Kits) and C5a receptor and that C5a receptor is involved in 7alphaOHChol-induced IL-8 (show IL8 ELISA Kits) expression via PI3K (show PIK3CA ELISA Kits) and MEK (show MAP2K1 ELISA Kits). Study demonstrated expression of IL-8 (show IL8 ELISA Kits) and C5a receptor primarily by 7alpha-hydroxycholesterol in monocytes/macrophages.
Reducing RPS19 (show RPS19 ELISA Kits) in tumor cells or blocking the C5a receptor 1-RPS19 (show RPS19 ELISA Kits) interaction decreases RPS19 (show RPS19 ELISA Kits)-mediated immunosuppression, impairs tumor growth, and delays the development of tumors in a transgenic model of breast cancer
C5aR (show C5AR1 ELISA Kits) expression in gastric cancer was associated with cancer progression, liver metastasis, and poor prognosis.
C5a in vitro caused activation (phosphorylation) of MAPKs and Akt (show AKT1 ELISA Kits) in cardiomyocytes, which required availability of both C5a receptors. These data suggest that polymicrobial sepsis causes cardiac dysfunction that appears to be linked to activation of MAPKs and Akt (show AKT1 ELISA Kits) in heart.
n the complex but clinically relevant DH model the local and systemic inflammatory immune response features both, C5-dependent and C5-independent characteristics. Activation of caspase-3 (show CASP3 ELISA Kits) in lung tissue after DH was C5-dependent whereas local inflammation in lung tissue was C5-independent.
The C5a/C5aR pathway is essential for up-regulating SphK1 (show SPHK1 ELISA Kits) expression through p38 MAPK (show MAPK14 ELISA Kits) activation in acute liver failure.in mice.
We induced anti-myeloperoxidase (show MPO ELISA Kits) vasculitis in bone marrow chimaeric mice and found that circulating and not bone marrow-derived C5 was required for disease
Choroidal neovascularization lesions trigger a systemic immune response, augmenting local ocular inflammation via the infiltration of IL-17 (show IL17A ELISA Kits)-producing gamma-delta T-cells, which are presumably recruited to the eye in a C5a-dependent manner.
Data (including data from studies in knockout mice) suggest that C5aR/C5aR (show C5AR1 ELISA Kits) (complement C5a/anaphylatoxin (show C5 ELISA Kits) C5a Receptor) signaling pathway is involved in neurocognitive injury in uninfected pups induced by malaria in pregnancy.
Carboxypeptidase B2 (show CPB2 ELISA Kits) deficiency reveals that complement C5a exacerbates infection in a murine polymicrobial sepsis model.
our results suggest that the detrimental effects of C5a in this model are partly mediated through CCR5 activation downstream of C5aR1 (show C5AR1 ELISA Kits), which may be evaluated for potential therapeutic exploitation in ALI/ARDS.
C5a signaling increases the expression of the chemokine (show CCL1 ELISA Kits) monocyte chemoattractant protein-1 (show CCL2 ELISA Kits) in hepatic metastases of colon cancer
Properdin (show CFB ELISA Kits) provides protection from Citrobacter rodentium-induced intestinal inflammation in a C5a/IL-6 (show IL6 ELISA Kits)-dependent manner.
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
, C5a anaphylatoxin
, anaphylatoxin C5a analog
, complement C5