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Browse our CD59 Proteins (CD59)

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CD59 Proteins (CD59)
On www.antibodies-online.com are 34 CD59 Proteins from 9 different suppliers available. Additionally we are shipping CD59 Antibodies (560) and CD59 Kits (40) and many more products for this protein. A total of 644 CD59 products are currently listed.
Synonyms:
1F5, 16.3A5, AA987121, Cd59, Cd59a, Cd59b, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MACIP, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20, protectin
list all proteins Gene Name GeneID UniProt
CD59 966 P13987
CD59 25407 P27274
CD59 12509 O55186

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CD59 Proteins (CD59) by Origin

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Top referenced CD59 Proteins

  1. Human CD59 Protein expressed in Human Cells - ABIN2005233 : Fletcher, Harrison, Lachmann, Neuhaus: Structure of a soluble, glycosylated form of the human complement regulatory protein CD59. in Structure (London, England : 1993) 1994 (PubMed)
    Show all 4 references for ABIN2005233

  2. Rat (Rattus) CD59 Protein expressed in Human Cells - ABIN2009444 : Picariello, Ferranti, Mamone, Roepstorff, Addeo: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry. in Proteomics 2008 (PubMed)
    Show all 3 references for ABIN2009444

  3. Cynomolgus CD59 Protein expressed in Human Cells - ABIN2009958 : Rudd, Morgan, Wormald, Harvey, van den Berg, Davis, Ferguson, Dwek: The glycosylation of the complement regulatory protein, human erythrocyte CD59. in The Journal of biological chemistry 1997 (PubMed)
    Show all 3 references for ABIN2009958

More Proteins for CD59 Interaction Partners

Human CD59 interaction partners

  1. Urinary CD59 and alpha-1 antitrypsin (show SERPINA1 Proteins) are significantly altered in hypertensive patients developing albuminuria.

  2. levels of CSF (show CSF2 Proteins) CD59 in neuromyelitis optica and multiple sclerosis

  3. Increased internalization of endothelial CD59 in intermittent hypoxia appeared to be cholesterol-dependent and was reversed by statins in a CD59-dependent manner.

  4. Low urine CD59 expression is associated with clear cell renal cell carcinoma (show MOK Proteins).

  5. Decreased CD59 expression in threatened miscarriage at late gestational ages leads to additional activation of a maternal immune response and serves as a possible predictor for premature birth.

  6. Data show that the palmitoylation mutation of linker for activation of T cells (LAT (show LAT Proteins))attenuated the signal transduction induced by glycosylphosphatidylinositol-anchored CD59 antigen in T cells.

  7. After blockage of CD59 function, the reactive Abs, regardless of their neutralizing activities, significantly enhanced specific ADCML of HIV-1 virions

  8. Genetic risk at the CFH (show CFH Proteins)-to-F13B locus was associated with higher levels of complement activation at the human macular RPE (show RPE Proteins)-choroid interface, as was cigarette smoking. Levels of CRP (show CRP Proteins) were substantially elevated in risk donors with smoking history.

  9. A primary homozygous Cys89Tyr CD59 deficiency in humans resulted in the amino acid substitution p.Cys89Tyr with ensuing failure of proper localization of the CD59 protein to the cell surface. (Review)

  10. Increased CD59 protein expression is associated with the outcome of patients with diffuse large B-cell lymphoma treated with R-CHOP (show DDIT3 Proteins) antineoplastic protocol.

Pig (Porcine) CD59 interaction partners

  1. Data demonstrate that the resistance of neonatal porcine Sertoli cells to human xenoantibody and complement-mediated lysis is associated with low expression of xenoantigen alpha-Gal and high production of the complement inhibitors clusterin (show CLU Proteins) and CD59.

Mouse (Murine) CD59 interaction partners

  1. Varicella-zoster virus infection upregulates host CD59 expression in a tissue-specific manner.

  2. This study support a role of Cd59a in controlling the innate immune status of the RPE (show RPE Proteins)-choroidal complex and emphasizes the particular vulnerability of this ocular compartment to the dysregulation of alternative complement pathway during aging

  3. results implicate CD59 as an important modulator of the immune response in NMO, and provide a novel animal model of NMO that closely recapitulates human NMO pathology.

  4. Soluble forms of CD59 (sCD59) have been investigated in mouse laser-induced choroidal neovascularization, a model for "wet" age related macular degeneration.

  5. both CD59 and C-PC could inhibit the progress of atherosclerosis, and the anti-atherosclerotic effects of C-PC might be fulfilled by promoting CD59 expression, preventing smooth muscle cell proliferation and the apoptosis of endothelial cells

  6. CD59a inhibits systemic autoimmunity in MRL/lpr (show FAS Proteins) mice through a complement-independent mechanism.

  7. While the connection between CFH (show CFH Proteins) deficiency and failure to upregulate CD59a remains unknown, these results suggest that expression of CD59 is tissue-specific and that neuroretinal regulation depends on CFH (show CFH Proteins).

  8. Actively immunized experimental autoimmune myasthenia gravis mice deficient in either CD55 or CD59 showed significant differences in adaptive immune responses and worsened disease outcome associated with increased levels of serum cytokines, modified production of acetylcholine receptor antibodies, and more complement deposition at the neuromuscular junction.

  9. HBx can up-regulate CD59 and Crry (show CR1L Proteins) expression in podocytes through activating the P38 (show CRK Proteins) pathway.

  10. CD59 has a role in growth of the choroidal neovascular complex in mice

CD59 Protein Profile

Protein Summary

This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Alternative names and synonyms associated with CD59

  • CD59 molecule, complement regulatory protein (CD59)
  • CD59 molecule, complement regulatory protein (Cd59)
  • CD59a antigen (Cd59a)
  • CD59b antigen (Cd59b)
  • 1F5 protein
  • 16.3A5 protein
  • AA987121 protein
  • Cd59 protein
  • Cd59a protein
  • Cd59b protein
  • EJ16 protein
  • EJ30 protein
  • EL32 protein
  • G344 protein
  • HRF-20 protein
  • HRF20 protein
  • MAC-IP protein
  • MACIF protein
  • MACIP protein
  • MEM43 protein
  • MIC11 protein
  • MIN1 protein
  • MIN2 protein
  • MIN3 protein
  • MIRL protein
  • MSK21 protein
  • p18-20 protein
  • protectin protein

Protein level used designations for CD59 Proteins (CD59)

1F5 antigen , 20 kDa homologous restriction factor , CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) , CD59 glycoprotein , Ly-6-like protein , MEM43 antigen , T cell-activating protein , human leukocyte antigen MIC11 , lymphocytic antigen CD59/MEM43 , membrane attack complex (MAC) inhibition factor , membrane attack complex inhibition factor , membrane inhibitor of reactive lysis , protectin , surface anitgen recognized by monoclonal antibody 16.3A5 , MAC-IP , MAC-inhibitory protein , MACIF , CD59 antigen , CD59b moleucle, complement regulatory protein , Cb59b molecule , CD59 homolog , CD59A glycoprotein , CD59B glycoprotein

GENE ID SPECIES
966 Homo sapiens
397347 Sus scrofa
25407 Rattus norvegicus
739046 Pan troglodytes
100009459 Oryctolagus cuniculus
101102670 Ovis aries
100173870 Pongo abelii
12509 Mus musculus
333883 Mus musculus
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