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Human CR1 ELISA Kit for Sandwich ELISA - ABIN415228
Kullo, Ding, Shameer, McCarty, Jarvik, Denny, Ritchie, Ye, Crosslin, Chisholm, Manolio, Chute: Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate. in American journal of human genetics 2011
Show all 3 Pubmed References
Genetic variation within the CR1 gene is associated with inflammation and the risk of incident coronary artery disease.
The distribution of the CR1 alleles, genotypes and haplotypes differed significantly among population in Brazil, Vietnam, India, Republic of Congo and Ghana.
CD16 (show CD16 ELISA Kits) and CD35 are important for neutrophil internalization of M. tuberculosis, whereas HIV-1 infection adversely affects opsonophagocytosis.
This study demonstrates an up-regulation of complement regulatory proteins, CD35 and CD55 (show CD55 ELISA Kits) in HIV associated pre-eclamptic compared to normotensive pregnancy.
Although B lymphocytes of active systemic lupus erythematosus (SLE) patients express lower level of CR1, the inhibitory capacity of this complement receptor is still maintained and its ligand-induced clustering results in significant inhibition of the main B cell functions, similar to that found in the case of healthy individuals.
CyaA binding did not trigger downstream signaling of CR3 (show ITGAM ELISA Kits) in human monocytes and CyaA-catalyzed elevation of cAMP effectively blocked CR3 (show ITGAM ELISA Kits) signaling initiated by a natural ligand.
the Putative Role of CR1 in Alzheimer's Disease
Knops blood group antigen a/b genotype was associated with increased susceptibility to severe malaria and the b/b genotype was associated with reduced risk of severe malaria.
The C4d/CR1 ratio is a simple and quickly determinable biomarker that enables the differentiation between infection and flare-up in febrile SLE patients at initial evaluation.
This meta-analysis further supports previous findings that CR1 rs6656401 polymorphism contributes to Alzheimer's Disease susceptibility.
These results demonstrate that local expression of Cr2 in the central nervous system is part of the axotomy reaction and is suggested to modulate subsequent complement mediated effects.
This study demonistrated that receptors for complement C3 (show C3 ELISA Kits) fragments (CR2/CR1) may represent a promising future approach for therapeutic immunomodulation after traumatic brain injury.
Data suggest that the Cr2KO mouse thus provides a new model system for the analysis of Cr1 and Cr2 functions in the immune response of the mouse.
Murine B cells predominantly express the Cr2 product from the Cr2 gene, whereas follicular dendritic cells (FDCs) almost exclusively express the Cr1 isoform generated from the Cr2 gene.
immune system uses three different CR1 (show TDGF1 ELISA Kits)/2-mediated effector functions to generate optimal antibody responses
Absence of CD21 (show CR2 ELISA Kits)/35 protects mice from chronic wasting disease.
We conclude that Cr2 regulates hippocampal neurogenesis
There is a significant reduction in the numbers of both neutrophils and macrophages in cardiac isografts isolated from mice treated with either complement receptor 2-Crry (show CR1L ELISA Kits) or CR2-factor H (show CFH ELISA Kits).
Differential expression of CD21 (show CR2 ELISA Kits) identifies developmentally and functionally distinct subsets of human transitional B cells.
functionally significant phenotype for the NZM2410 Cr2 allele and strongly support its role as a lupus susceptibility gene
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.
, C3b/C4b receptor
, CD35 antigen
, Knops blood group antigen
, complement component receptor 1
, complement receptor type 1
, complement C3d receptor
, complement receptor type 2
, expressed in B lymphocytes
, 5I2 antigen
, Complement receptor related protein
, antigen 5I2
, complement component receptor 1-like protein
, complement regulatory protein Crry
, LOW QUALITY PROTEIN: complement receptor type 1
, complement component (3b/4b) receptor 1 (Knops blood group)
, complement component (3d/Epstein Barr virus) receptor 2
, complement receptor type 1-like protein
, cr1 (CD35)
, complement receptor 1