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Browse our FCN2 Proteins (FCN2)

Full name:
Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin) Proteins (FCN2)
On are 9 Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin) (FCN2) Proteins from 6 different suppliers available. Additionally we are shipping FCN2 Antibodies (45) and FCN2 Kits (15) and many more products for this protein. A total of 73 FCN2 products are currently listed.
EBP-37, Fcn2, FCNB, FCNL, ficolin-2, P35
list all proteins Gene Name GeneID UniProt
FCN2 2220 Q15485
FCN2 14134 O70497
FCN2 114091 P57756

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FCN2 Proteins (FCN2) by Origin

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More Proteins for FCN2 Interaction Partners

Human Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin) (FCN2) interaction partners

  1. association of FCN2 polymorphisms with nephritis and severe cumulative damage in SLE patients; no association with rheumatoid arthritis development

  2. -557 A>G, -64 A>C and +6424 G>T SNPs of the FCN2 gene were correlated with pulmonary TB.

  3. FCN2 and MBL2 (show MBL2 Proteins) allele frequencies were similarly distributed in early and late age-related macular degeneration cases compared with controls

  4. this study provide novel insight in the binding and complement activating capacity of the lectin pathway initiation molecules ficolin-2 and ficolin-3 (show FCN3 Proteins) towards relevant Gram-negative pathogens of pathophysiological relevance.

  5. Findings indicate the FCN2 variant +6359C>T is associated with the occurrence of visceral leishmaniasis and that ficolin-2 serum levels are elevated in Leishmania infections.

  6. L-ficolin modulates the immune response to A. fumigatus.

  7. Very low serum ficolin-2 levels were associated with higher risk of 30-day mortality in community-acquired pneumonia patients.

  8. paper identifies phosphocholine moieties of pneumococcal teichoic acid as a novel L-ficolin ligand

  9. There is lack of association of serum mannose-binding lectin (show MBL2 Proteins) or ficolins with complement activation in patients with antiphospholipid antibodies.

  10. MBL (show MBL2 Proteins) deficiency or MBL2 (show MBL2 Proteins) and FCN2 mutations were not associated with an improved hepatitis B vaccine response in Kenyan HIV-1 uninfected individuals.

Mouse (Murine) Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin) (FCN2) interaction partners

  1. Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans.

  2. Data show that ficolin-B is stored in and set free from immature granulocytic myeloid cells indicating a role in the early infection-induced cellular response of these inflammatory cells.

  3. FcnA-deficient and FcnA/ficolin B double-deficient mice lack FcnA-mediated complement activation in the sera, because of absence of complexes comprising FcnA and MBL-associated serine proteases.

  4. These results identify mouse ficolin-B as a functional member of the ficolin family activating complement via the lectin pathway.

  5. Results show that ficolin B in mouse bone marrow is an oligomeric protein. Ficolin B contained very low, but detectable, amounts of MASP-2 and sMAP and showed detectable C4-deposition activity on immobilized N-acetylglucosamine.

  6. Ficolin B exhibited a distinct ontogeny pattern that switched from embryonic liver to postnatal bone marrow and spleen. The cells that express ficolin B mRNA were identified as belonging to the myeloid cell lineage.

  7. Ficolin B showed multimeric structures and revealed binding to both N-acetylglucosamine and N-acetylgalactosamine. Ficolin B specifically recognized sialic acid residues. Ficolin B plays a distinct role through its unique carbohydrate-binding specificity.

FCN2 Protein Profile

Protein Summary

The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with FCN2

  • ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) (FCN2)
  • ficolin (collagen/fibrinogen domain containing) 1 (FCN1)
  • ficolin B (Fcnb)
  • EBP-37 protein
  • Fcn2 protein
  • FCNB protein
  • FCNL protein
  • ficolin-2 protein
  • P35 protein

Protein level used designations for FCN2

ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) , ficolin 2 , 37 kDa elastin-binding protein , L-ficolin , collagen/fibrinogen domain-containing protein 2 , ficolin B , ficolin-2 , ficolin-B , ficolin-beta , serum lectin p35

473087 Pan troglodytes
2220 Homo sapiens
396881 Sus scrofa
497016 Bos taurus
14134 Mus musculus
114091 Rattus norvegicus
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