Browse our FCN3 Proteins (FCN3)

Full name:
Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) Proteins (FCN3)
On are 4 Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3) Proteins from 4 different suppliers available. Additionally we are shipping FCN3 Antibodies (45) and FCN3 Kits (16) and many more products for this protein. A total of 72 FCN3 products are currently listed.
list all proteins Gene Name GeneID UniProt
FCN3 8547 O75636

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Human Ficolin (Collagen/fibrinogen Domain Containing) 3 (Hakata Antigen) (FCN3) interaction partners

  1. results suggest that anti-ficolin-3 antibodies could be useful for the diagnosis of active nephritis in SLE patients

  2. this study shows that H-ficolin may aid clearance of influenza A virus by promoting monocyte uptake of the virus, while reducing viral replication and virus-induced TNF-a (show TNF Proteins) responses in these cells

  3. These results suggest that polymorphisms in the FCN3 gene cooperate to increase ficolin-3 concentration and that it might contribute to leprosy susceptibility by favoring Mycobacterium leprae infection.

  4. subjects that were heterozygote carriers of both FCN2 (show FCN2 Proteins) + 6424 and FCN3 + 1637delC were sufficient mannan-binding lectin (show MBL2 Proteins) producers

  5. in patients with systemic lupus erythematosus, there was no significant association between ficolin-1 (show FCN1 Proteins) and ficolin-3 with lupus nephritis

  6. Monitoring serum H-ficolin levels was shown to be of no benefit in terms of predicting severe infection.

  7. Serum levels of ficolin-2 (show FCN2 Proteins) and ficolin-3 were significantly lower in the cardiac syndrome X patients compared to controls.

  8. LPS induces a tissue-specific recruitment of ficolin-3 and ficolin-1 in the lung and systemic compartment, respectively, suggesting an important role of distinct lectin complement pathway initiators in the local pulmonary and systemic host defence.

  9. Lower serum ficolin-3 levels were correlated with injury severity following traumatic brain injury.

  10. this study provide novel insight in the binding and complement activating capacity of the lectin pathway initiation molecules ficolin-2 (show FCN2 Proteins) and ficolin-3 towards relevant Gram-negative pathogens of pathophysiological relevance.

FCN3 Protein Profile

Protein Summary

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified.

Alternative names and synonyms associated with FCN3

  • ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen) (FCN3)
  • FCNH protein
  • HAKA1 protein

Protein level used designations for FCN3

H-ficolin , collagen/fibrinogen domain-containing lectin 3 p35 , collagen/fibrinogen domain-containing protein 3 , ficolin 3 , ficolin-3

8547 Homo sapiens
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