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KLK12 gene silencing reduces gastric cancer cell proliferation and migration.
Data indicate that the KLK12 SNP rs3865443 was not associated with tumor aggressiveness but showed marginal association with prostate cancer risk for the rare homozygote.
KLK12 gene is markedly overexpressed in gastric cancer
Kallikrein 5 (show KLK5 Proteins) and kallikrein 12 cleave human influenza hemagglutinins and activate thrombolytic zymogens.
the proangiogenic activity of KLK12 in lung endothelial cells was not related to a kinin release
Results suggest that kallikrein-related peptidase 12 (KLK12) splice variant KLK12sv3 can be regarded as a marker of good prognosis in breast cancer.
Serine protease (show F2 Proteins) of Kazal-type (SPINK6 (show SPINK6 Proteins)) expressed in normal human skin is a potent natural inhibitor of Kallikrein (show KLK4 Proteins)-related peptidases, KLK12 and KLK13 (show KLK13 Proteins).
KLK12 may indirectly regulate the bioavailability and activity of several growth factors through processing of their CCN binding partners
4 types of polymorphisms were found in Japanese gastric cancer: 1 at an intron 4 splice-donor site (c.457+2T>C), 2 in exon 6 (c.618_619delTG:p.Cys206fsX72 & c.735G>A:p.Met245Ile), & 1 in intron 3. c.457+2C/C has no hK12 serine protease (show F2 Proteins) expression.
KLK12 has trypsin-like activity, cleaving peptide bonds after both arginine & lysine. It quickly loses its activity due to autodegradation, its activity can also be rapidly inhibited by zinc ions & by alpha2-antiplasmin through covalent complex formation.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.
kallikrein-related peptidase 12
, kallikrein 12
, kallikrein-like protein 5