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Mouse (Murine) PLG Protein expressed in Mouse - ABIN491397
Bruno, Cuello: Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 3 Pubmed References
Human PLG Protein expressed in Human - ABIN491018
Komissarov, Florova, Idell: Effects of extracellular DNA on plasminogen activation and fibrinolysis. in The Journal of biological chemistry 2011
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Mouse (Murine) PLG Protein expressed in Mouse - ABIN491392
Van Den Broeck, Stevenaert, Taveirne, Debacker, Vangestel, Vandekerckhove, Taghon, Matthys, Plum, Held, Dewerchin, Yokoyama, Leclercq: Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator. in Blood 2008
Show all 2 Pubmed References
Cow (Bovine) PLG Protein expressed in Bovine - ABIN491395
Coy, Jiménez-Movilla, García-Vázquez, Mondéjar, Grullón, Romar: Oocytes use the plasminogen-plasmin system to remove supernumerary spermatozoa. in Human reproduction (Oxford, England) 2012
Horse (Equine) PLG Protein expressed in Horse - ABIN780187
Velineni, Timoney: Characterization and protective immunogenicity of the SzM protein of Streptococcus zooepidemicus NC78 from a clonal outbreak of equine respiratory disease. in Clinical and vaccine immunology : CVI 2013
Data suggest that protein aggregates interact with tissue-type plasminogen activator (show PLAT Proteins) and plasminogen to efficiently generate plasmin; this aggregate-bound plasmin is shielded from inhibition by alpha-2-antiplasmin (show Alpha2 Antiplasmin Proteins) and degrades protein aggregates to release smaller, soluble but relatively hydrophobic peptide fragments; these fragments bind to and are cytotoxic to microglia (by not vascular endothelial cells).
The mechanism for plasminogen/M protein binding uncovered here may facilitate targeting of group A Streptococcus pyogenes virulence factors for disease management
t-PA (show PLAT Proteins) binds to Lys91 in the MBP (show MBL2 Proteins) NH2-terminal region and PLG binds to Lys122 in the MBP (show MBL2 Proteins) COOH-terminal region. This proximity promotes the activation of PLG by t-PA (show PLAT Proteins).
in the presence of platelet polyphosphate and the downstream substrate fibrin, alphaFXIIa is a highly efficient and favorable plasminogen activator.
Plasmin(ogen) serves as a favorable biomarker for prediction of survival in advanced high-grade serous ovarian cancer
Our findings indicate a new pathway for bradykinin formation in patients with HAE, in which FXII (show F12 Proteins) is cleaved and activated by plasmin.
VWF (show VWF Proteins) susceptibility to plasmin proteolysis at K1491-R1492 is modulated by local N-linked glycan expression within A1A2A3, and specifically inhibited by heparin binding to the A1 domain.
Plasminogen and P4HA2 (show P4HA2 Proteins) are involved in vascular remodelling and angiogenesis, suggesting a high relevance of these processes for the pathogenic mechanisms underlying this type of vasculitis
Plasminogen and OxPL-PLG were lower in patients presenting with an acute MI than in those with stable CAD and also in those with atherothrombotic MI (Type 1) vs. those with non-atherothrombotic MI (Type 2).
Although carriers with PLG:p.Ala620Thr show low plasminogen activity, this is not a predisposing variant for aHUS; and individuals of dysplasminogenemia are not at significantly increased risk of aHUS.
The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte.
The current study suggests the existence of an active TNF-alpha (show TNF Proteins)-plasminogen-plasmin autocrine/paracrine loop on the massively infiltrated polymorphonuclear neutrophils inside udders of drying-off cows.
examination of interaction with streptococcal plasminogen activator PauA
confirmed the ability of Plg/Pla to both promote efferocytosis and override the prosurvival effect of LPS (show TLR4 Proteins) via annexin A1 (show ANXA1 Proteins).
findings identify plasmin as a decisive checkpoint in the inflammatory response during Macrophage activation syndrome (MAS (show MAS1 Proteins)) and a potential novel therapeutic target for MAS (show MAS1 Proteins).
Deficiency of plasminogen delays onset of autoimmune neuroinflammatory disease and protects from the development of paralysis.
Plasminogen may regulate DPP-4 (show DPP4 Proteins) activity and glucose metabolism.
Plasminogen-deficient mice frequently develop colon lesions and rectal prolapses.
manganese transport protein (show SLC11A2 Proteins) C (show PROC Proteins) (MntC) is an extracellular matrix- and plasminogen-binding protein (show ENO1 Proteins)
Plg from mouse plasma contains oxPtdPC adducts that are not affected by the action of Lp-PLA(2 (show Lp-PLA2 Proteins)), suggesting that linkage to Plg protects oxPtdPCs from metabolism during their transport in the plasma.
plg-/- and tPA (show PLAT Proteins)-/- mice exhibit brain parenchymal fibrin deposits that appear to result from reduced neurovascular integrity
plasminogen-dependent proteolysis has a beneficial effect during neurological recovery after stroke.
Pla-induced mononuclear cell recruitment in vivo was dependent on protease-activated receptor-1 activation of the MEK/ERK/NF-kappaB pathway, which led to the release of CCL2 and activation of CCR2.
The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.
, lipoprotein, Lp(a)
, plasmin heavy chain A
, plasmin light chain B