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Human PLG Protein expressed in Human - ABIN491018
Komissarov, Florova, Idell: Effects of extracellular DNA on plasminogen activation and fibrinolysis. in The Journal of biological chemistry 2011
Show all 2 references for ABIN491018
Cow (Bovine) PLG Protein expressed in Bovine - ABIN491395
Coy, Jiménez-Movilla, García-Vázquez, Mondéjar, Grullón, Romar: Oocytes use the plasminogen-plasmin system to remove supernumerary spermatozoa. in Human reproduction (Oxford, England) 2012
Horse (Equine) PLG Protein expressed in Horse - ABIN780187
Velineni, Timoney: Characterization and protective immunogenicity of the SzM protein of Streptococcus zooepidemicus NC78 from a clonal outbreak of equine respiratory disease. in Clinical and vaccine immunology : CVI 2013
Suggest that tubulointerstitial plasmin is associated with inflammation leading to renal fibrosis, and can cause the decline in renal function seen in patients with IgA nephropathy.
Plasminogen binding and activation by different glycolytic enzymes of M. pneumoniae play a role in successful colonization of the human respiratory tract.
reduced proteolytic activity of plasmin on structures of growing thrombi, rather than on complement activation fragments, explains the association of plasminogen deficiency with aHUS.
Zinc modulates fibrinolysis by attenuating tPA (show PLAT Proteins)-mediated plasminogen activation and plasmin-induced fibrin degradation.
Plasmin cleavage of iC3b provides a complement regulatory pathway that is as efficient as FI/CR1 but does not require a cellular cofactor.
PLG is the third replicated shared genetic risk factor of atherosclerosis and periodontitis.
Data show that preincubation with plasminogen, wild-type group A Streptococcus (GAS) NS88.2 degraded complement C3b.
whereas the presence of plasminogen did not affect the factor I cofactor activity of C4BP (show C4BPA Proteins), the activation of plasminogen by urokinase-type plasminogen activator (show PLAU Proteins) to active plasmin was significantly augmented in the presence of C4BP (show C4BPA Proteins).
These studies demonstrate that GAS virulence can be explained by disparate hPg (show GNRH1 Proteins) activation by SK2a and SK2b coupled with the coinherited M-proteins of these strains
PAM (show PAM Proteins) activated Plasminogen Glycoform II.
The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte.
The current study suggests the existence of an active TNF-alpha (show TNF Proteins)-plasminogen-plasmin autocrine/paracrine loop on the massively infiltrated polymorphonuclear neutrophils inside udders of drying-off cows.
examination of interaction with streptococcal plasminogen activator PauA
Plasminogen-deficient mice frequently develop colon lesions and rectal prolapses.
manganese transport protein (show SLC11A2 Proteins) C (show PROC Proteins) (MntC) is an extracellular matrix- and plasminogen-binding protein (show ENO1 Proteins)
Plg from mouse plasma contains oxPtdPC adducts that are not affected by the action of Lp-PLA(2 (show Lp-PLA2 Proteins)), suggesting that linkage to Plg protects oxPtdPCs from metabolism during their transport in the plasma.
plg-/- and tPA (show PLAT Proteins)-/- mice exhibit brain parenchymal fibrin deposits that appear to result from reduced neurovascular integrity
plasminogen-dependent proteolysis has a beneficial effect during neurological recovery after stroke.
Pla-induced mononuclear cell recruitment in vivo was dependent on protease-activated receptor-1 activation of the MEK/ERK/NF-kappaB pathway, which led to the release of CCL2 and activation of CCR2.
Plg may play an important role in innate immunity by changing expression of genes that contribute to phagocytosis.
Plasminogen is a key molecular determinant of inflammatory joint disease capable of simultaneously driving or ameliorating arthritis pathogenesis in distinct anatomic locations in the same subject.
Plasmin suppresses brain metastasis in two ways: by converting membrane-bound astrocytic FasL (show FASL Proteins) into a paracrine death signal for cancer cells, and by inactivating the axon pathfinding molecule L1CAM (show L1CAM Proteins), which metastatic cells express for spreading along brain capillaries and for metastatic outgrowth.
Plasminogen stimulates autocrine cytokine production in human airway smooth muscle cells in a manner mediated by plasmin and annexin A2 (show ANXA2 Proteins).
The protein encoded by this gene is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.
, lipoprotein, Lp(a)
, plasmin heavy chain A
, plasmin light chain B