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Integrin alpha 2 Proteins (ITGA2)
On www.antibodies-online.com are 10 Integrin alpha 2 (ITGA2) Proteins from 3 different suppliers available. Additionally we are shipping Integrin alpha 2 Antibodies (491) and Integrin alpha 2 Kits (13) and many more products for this protein. A total of 519 Integrin alpha 2 products are currently listed.
Synonyms:
BR, CD49B, DX5, gpi, GPIa, HPA-5, PGI, pgi-1, VLA-2, VLAA2, wu:fc02c05, zgc:86919
list all proteins Gene Name GeneID UniProt
ITGA2 16398 Q62469
Rat ITGA2 ITGA2 170921  
ITGA2 3673 P17301

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Integrin alpha 2 Proteins (ITGA2) by Origin

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More Proteins for Integrin alpha 2 Interaction Partners

Zebrafish Integrin alpha 2 (ITGA2) interaction partners

  1. The differential expression of gpia and gpib in zebrafish suggests partition or divergence of gpi functions between the two duplicates.

  2. Comparison of glucose phosphase isomerase (GPI) genes from several vertebrates suggests that GPIs are being subjected to purifying selection to maintain the polarity and volume of the protein, but not its charge.

Mouse (Murine) Integrin alpha 2 (ITGA2) interaction partners

  1. low expression of alpha2beta1 integrin increased protein kinase B (AKT) activation and alpha-smooth muscle actin (alpha-SMA) expression. This occurred due to the instability of phosphatase and tensin homolog (PTEN) in myofibroblasts on fibrillar collagen.

  2. Ceacam1 (show CEACAM1 Proteins) is essential for normal integrin aIIbb3-mediated platelet function; the disruption of mouse Ceacam1 (show CEACAM1 Proteins) induced moderate integrin aIIbb3-mediated functional defects.

  3. HRG (show HRG Proteins) binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I.

  4. LG3, through interactions with alpha2beta1 integrins on recipient-derived cells leading to activation of ERK1/2 and increased migration, favors myointimal thickening

  5. IFN-gamma (show IFNG Proteins) induces aberrant CD49b+ NK cell recruitment and pregnancy failure through regulating CX3CL1 (show CX3CL1 Proteins).

  6. alphaIIbbeta3 regulates Syk (show SYK Proteins) through an ITAM-independent pathway in mice and provide novel insight into the course of events underlying Syk (show SYK Proteins) activation and hemITAM phosphorylation by CLEC-2 (show CLEC1B Proteins)

  7. the collagen receptors DDR1 (show DDR1 Proteins) and integrin a2b1 contribute to regulate GBM-maturation and to control matrix accumulation.

  8. alpha2beta1 integrin contributes to the pathogenesis of retinopathy. We describe a newly identified role for alpha2beta1 integrin in mediating hypoxia-induced Muller cell VEGF-A (show VEGFA Proteins) production.

  9. required for the migration of memory CD4 (show CD4 Proteins) T-cell precursors into their survival niches of the bone marrow

  10. alpha2beta1 integrin is expressed on synovial Th17 cells from CIA (show NCOA5 Proteins) mice. Its neutralization reduced inflammation, cartilage degradation, bone erosion, RANKL (show TNFSF11 Proteins) & IL-17 (show IL17A Proteins) levels, & the numbers of osteoclasts and TH17 cells.

Human Integrin alpha 2 (ITGA2) interaction partners

  1. Data indicate no association of maternal or fetal ITGA2 C807T SNP, ITGB3 (show ITGB3 Proteins) T1565C SNP, PECAM1 (show PECAM1 Proteins) CTG - GTG (show GGT1 Proteins) and SELP (show SEPP1 Proteins) A/C polymorphisms with fetal growth restriction (FGR (show FGR Proteins)).

  2. The most common HPA (show HPSE Proteins) genotypes among Saudis were HPA-1 (show HPSE Proteins) a + b- (75%), HPA-2 a + b- (62%), HPA-3 a + b- (51.5%), HPA (show HPSE Proteins)-4 a + b- (99%), HPA-5 a + b- (76.5%), HPA (show HPSE Proteins)-6 a + b- (100%) and HPA (show HPSE Proteins)-15 a + b + (50%). The prevalent allele among the HPA (show HPSE Proteins) systems was (a), except in the HPA (show HPSE Proteins)-15 system where the (b) allele was found in 52% of the subjects.

  3. high miR (show MLXIP Proteins)-128 expression suppressed osteosarcoma cell migration, invasion, and EMT (show ITK Proteins) development through targeting ITGA2, which may be recommended as a therapeutic target for osteosarcoma.

  4. Study identified a novel RANKL (show TNFSF11 Proteins) function in the promotion of cell adhesion to type I collagen through the RANKL (show TNFSF11 Proteins)-NF-kappa B (show NFKB1 Proteins)-integrin alpha 2 pathway and found integrin alpha2 and RANKL (show TNFSF11 Proteins) up-regulated in non small cell lung carcinoma.

  5. High ITGA2 expression is associated with cervical cancer.

  6. PDI-mediated disulfide bond exchange plays a pivotal role in the post-ligation phase of alphaIIbbeta3-mediated adhesion to fibrinogen, while this step in alphavbeta3-mediated adhesion is independent of disulfide exchange

  7. Our results indicate that GpIa-807T and GpIIIa (show ITGB3 Proteins)-PlA2 (show YWHAZ Proteins) may be susceptibility alleles for in vitro fertilization implantation failure.

  8. PFL-mediated downregulation of integrin and EGFR contributes to the inhibition of tumor growth in vitro and in vivo. This novel anti-cancer mechanism of PFL suggests that this lectin would be useful as an anti-cancer drug or an adjuvant for other drugs.

  9. HRG (show NRG1 Proteins) binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I.

  10. The Glycoprotein Ia (show MMRN1 Proteins) C807T polymorphism might be a risk factor for the development and relapse of Acute Coronary Syndrome

Cow (Bovine) Integrin alpha 2 (ITGA2) interaction partners

  1. Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.

  2. both the gpIb-VWF (show VWF Proteins) interaction and the integrin alpha(2)beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II (show GSTA3 Proteins))beta(1) makes a greater contribution to adhesion to type I collagen because less VWF (show VWF Proteins) is bound

Integrin alpha 2 (ITGA2) Protein Profile

Protein Summary

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Integrin alpha 2 (ITGA2)

  • glucose phosphate isomerase a (gpia)
  • integrin alpha 2 (Itga2)
  • integrin, alpha 2 (Itga2)
  • integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) (ITGA2)
  • BR protein
  • CD49B protein
  • DX5 protein
  • gpi protein
  • GPIa protein
  • HPA-5 protein
  • PGI protein
  • pgi-1 protein
  • VLA-2 protein
  • VLAA2 protein
  • wu:fc02c05 protein
  • zgc:86919 protein

Protein level used designations for Integrin alpha 2 Proteins (ITGA2)

pgi1 , CD49 antigen-like family member B , GPIa , VLA-2 receptor, alpha 2 subunit , VLA-2 subunit alpha , collagen receptor , integrin alpha-2 , platelet membrane glycoprotein Ia , VLA2 receptor, alpha-2 subunit , human platelet alloantigen system 5 , platelet antigen Br , platelet glycoprotein GPIa , very late activation protein 2 receptor, alpha-2 subunit , VLA-2 alpha chain

GENE ID SPECIES
246094 Danio rerio
16398 Mus musculus
170921 Rattus norvegicus
3673 Homo sapiens
281872 Bos taurus
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