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Our results suggest that H19 (show NCKAP1 ELISA Kits) functions as a competitive endogenous RNA (ceRNA) by acting as a sink for miR-17-5p, revealing a potential ceRNA regulatory network involving H19 (show NCKAP1 ELISA Kits) and miR-17-5p with a role in the modulation of YES1 expression
c-Yes plays an important role in migration and invasion of epithelial ovarian cancer.
Up-regulation of miR (show MLXIP ELISA Kits)-210 inhibits hepatocellular carcinoma cell proliferation. Yes1 is a target of miR (show MLXIP ELISA Kits)-210 and affects cell proliferation in HCC (show FAM126A ELISA Kits).
findings indicate that miR (show MLXIP ELISA Kits)-203 induces the apoptosis of KB cells by directly targeting Yes-1, suggesting its application in anti-cancer therapeutics
Results demonstrate a unique role for Yes in phosphorylation of FAK (show PTK2 ELISA Kits) and in promoting PCa (show FLVCR1 ELISA Kits) metastasis. Therefore, phosphorylated FAK (show PTK2 ELISA Kits) Y861 and increased Yes expression may be predictive markers for PCa (show FLVCR1 ELISA Kits) metastasis.
results indicated that miR-17-5p might play a role in human ovarian cancer by up-regulating YES1 expression.
Increased YES/SFK activation might serve as a clinical biomarker for predicting tumor resistance to IGF-1R (show IGF1R ELISA Kits) inhibition.
YES1 and YAP (show YAP1 ELISA Kits) transcript levels were higher in liver metastases of patients with colon cancer after 5FU-based neoadjuvant chemotherapy.
YES kinase as a proximal glucose-specific signal in the Cdc42 (show CDC42 ELISA Kits)-signaling cascade.
we identified CRKL (show CRKL ELISA Kits)/YES as critical interrelated pathways necessary for rhabdomyosarcoma cell growth and survival and suggest a potential therapeutic role of SRC (show SRC ELISA Kits) family kinase inhibition in the treatment of rhabdomyosarcoma.
investigated signaling pathways in early development by comparison of the phosphoproteome of wild type embryos with Fyn (show FYN ELISA Kits)/Yes knockdown embryos that display specific convergence and extension cell movement defects
Ganglioside GD3 enhances invasiveness of gliomas by forming a complex with PDGFRalpha and Yes Kinase.
serum also activates TEAD-dependent transcription in a time- and dose-dependent manner and we identify Inter-alpha-inhibitor (IalphaI) as a component in serum capable of activating the Yes/YAP (show YAP1 ELISA Kits)/TEAD pathway
Differentiation of embryonic stem cells is driven by c-Src (show SRC ELISA Kits) is antagonized by c-Yes.
The antiapoptotic effect of YES1 activation in response to testicular heat insult may mediate via the regulation of extracellular signal-regulated kinase (ERK (show EPHB2 ELISA Kits))/metastasis-associated 1 (MTA1 (show MTA1 ELISA Kits)) cascade.
Results suggest that LKB1 (show STK11 ELISA Kits) inactivation in the context of RAS activation facilitates metastasis by inducing an SFK-dependent expansion of a prometastatic, CD24 (show CD24 ELISA Kits)(+) tumor subpopulation.
YAP (show YAP1 ELISA Kits), TEAD2 and Yes are highly expressed in self-renewing embryonic stem cells, and are activated by LIF (show LIF ELISA Kits).
eIF4E (show EIF4E ELISA Kits) and yes have cooperative roles in oncogenic transformation
Data show that in response to angiotensin II, the ability of ERK1/2 (show MAPK1/3 ELISA Kits) to remain within the cytoplasm or translocate into the nucleus is controlled by c-Src (show SRC ELISA Kits)/Yes/Fyn (show FYN ELISA Kits) or heterotrimeric G protein/PKCzeta (show PRKCZ ELISA Kits) signaling, respectively.
Data imply that distinct modes of spatial activation and membrane delivery, under the control of specific acylation attachment sequences and endosome sub-type requirements, define distinct properties of the three SFKs (Src (show SRC ELISA Kits) family kinases).
Binding of CD95 Ligand (show FASL ELISA Kits) to CD95 (show FAS ELISA Kits) on glioblastoma cells recruit Yes and the p85 (show ECM1 ELISA Kits) subunit of phosphatidylinositol 3-kinase to CD95 (show FAS ELISA Kits), which signal invasion via the glycogen synthase kinase 3-beta (show GSK3b ELISA Kits) pathway and subsequent expression of matrix metalloproteinases.
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.
Yamaguchi sarcoma oncogene
, cellular yes-1 protein
, proto-oncogene c-Yes
, proto-oncogene tyrosine-protein kinase YES
, tyrosine-protein kinase Yes
, protein-tyrosine kinase
, tyrosine-protein kinase yes
, viral oncogene yes-1 homolog 1
, v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
, viral oncogene yes-1 homolog 1-like
, proto-oncogene tyrosine-protein kinase Yes-like
, proto-oncogene tyrosine-protein kinase Yes
, viral oncogene yes homolog
, c-yes proto-oncogene
, Yamagichi sarcoma viral (v-yes-1) oncogene homolog 1
, Yamaguchi sarcoma viral oncogene homolog 1