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Browse our anti-BRCA2 (BRCA2) Antibodies

Full name:
anti-Breast Cancer 2, Early Onset Antibodies (BRCA2)
On www.antibodies-online.com are 90 Breast Cancer 2, Early Onset (BRCA2) Antibodies from 24 different suppliers available. Additionally we are shipping BRCA2 Kits (25) and BRCA2 Proteins (2) and many more products for this protein. A total of 120 BRCA2 products are currently listed.
Synonyms:
AI256696, AW045498, BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2, RAB163
list all antibodies Gene Name GeneID UniProt
BRCA2 12190 P97929
BRCA2 675 P51587
BRCA2 360254  

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Most Popular Reactivities for anti-BRCA2 (BRCA2) Antibodies

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anti-Mouse (Murine) BRCA2 Antibodies:

anti-Human BRCA2 Antibodies:

anti-Rat (Rattus) BRCA2 Antibodies:

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Top referenced anti-BRCA2 Antibodies

  1. Human Monoclonal BRCA2 Primary Antibody for IHC, IHC (p) - ABIN445491 : Wu, Jiang, Thangaraju, Wu, Couch: Induction of the BRCA2 promoter by nuclear factor-kappa B. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for ABIN445491

  2. Human Monoclonal BRCA2 Primary Antibody for IHC, IHC (fro) - ABIN445493 : Bernard-Gallon, Déchelotte, Vissac, Aunoble, Cravello, Malpuech, Bignon: BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite. in Breast cancer research : BCR 2001 (PubMed)
    Show all 2 references for ABIN445493

  3. Human Polyclonal BRCA2 Primary Antibody for IHC, ELISA - ABIN1533759 : Wooster, Bignell, Lancaster, Swift, Seal, Mangion, Collins, Gregory, Gumbs, Micklem: Identification of the breast cancer susceptibility gene BRCA2. in Nature 1996 (PubMed)
    Show all 2 references for ABIN1533759

More Antibodies against BRCA2 Interaction Partners

Zebrafish Breast Cancer 2, Early Onset (BRCA2) interaction partners

  1. Carcinogenesis in zebrafish with combined mutations in tp53 (show TP53 Antibodies) and brca2 typically requires biallelic mutation or loss of at least one of these genes.

  2. The novel role of Brca2 in organizing the vertebrate egg nucleus may provide new insights into the origin of ovarian cancer

  3. critical roles for brca2 in ovarian development and tumorigenesis in reproductive tissues

Mouse (Murine) Breast Cancer 2, Early Onset (BRCA2) interaction partners

  1. Merit40 (show BABAM1 Antibodies) mutation exacerbated ICL-induced chromosome instability in the context of concomitant Brca2 deficiency but not in conjunction with Fancd2 (show FANCD2 Antibodies) mutation.

  2. Heterozygous and homozygous Brca2 mutation may lead to dysfunction in T cell populations.

  3. BRCA2 exon 27 domain maintains chromosomal integrity at both stalled and collapsed replication forks consistent with involvement in both replication fork maintenance and double strand break repair.

  4. we use a genetically engineered mouse model of BRCA2-associated hereditary breast cancer to study drug resistance to several types of chemotherapy and PARP (show PARP1 Antibodies) inhibition.

  5. BRCA2-mediated sequestration of nuclear RAD51 (show RAD51 Antibodies) serves to prevent inappropriate DNA interactions.

  6. BRCA2 directly represses the expression of IFN-related genes

  7. the models reveal novel aspects of cancer evolution in carriers of germline BRCA2 mutations, provide new insights into the tumour suppressive role of BRCA2

  8. genetic stability, and hematopoietic differentiation potential of gene-corrected Brca2(Delta) (27/) (Delta) (27) iPSCs, achievements and limitations in the application of current reprogramming approaches in hematopoietic stem cell therapy are also discussed.

  9. Results suggest that cellular levels of Brca2 and Rad51 (show RAD51 Antibodies) are mutually dependent on each other, and that low levels of these proteins provide selective pressure for reduction of p53 (show TP53 Antibodies), which permits cell growth

  10. BRCA2 accumulates DNA damage, which triggers checkpoint signalling and ARF (show CDKN2A Antibodies) activation

Human Breast Cancer 2, Early Onset (BRCA2) interaction partners

  1. Data suggest that, similar to Caucasians, a significant proportion of Asian ovarian cancer was attributed to germline mutations in BRCA1 and to a lesser extent in BRCA2.

  2. We found an approximately approximately 3 fold increased rate of high RS among BRCA1 and 2 carriers with ER positive breast cancer (BC)compared with the general BC population.

  3. results suggests that BRCA1 mutation carriers with breast cancer are more likely to have P53 (show TP53 Antibodies) overexpression compared with BRCA2 mutation carriers and non-carriers (Meta-analysis).

  4. We recommend BRCA1/2 genetic testing to all Chinese women diagnosed with EOC to identify HBOC families, to provide genetic counseling and clinical management for at-risk relatives. Mutation carriers may also benefit from PARP (show COL11A2 Antibodies)-targeted therapies.

  5. BRCA2 mutation is associated with breast cancer.

  6. Five patients were identified with intragenic mutations predicted to restore BRCA1/2 open reading frames, including two patients with multiple independent reversion alleles.

  7. the primary goal of this study was to use multiplex PCR with morphological and immunohistochemical methods for the detection of BRCA mutation(BRCA1 or BRCA2), mtDNA 4977 deletion, and HPV genotyping in familial and nonfamilial breast cancers

  8. BRCA2-truncated protein resulted from the frame shift mutation was found to lose two putative nuclear localization signals and a Rad51 (show RAD51 Antibodies)-binding motif in the extreme C-terminal region by bioinformatic prediction

  9. soluble alpha-fetoprotein (show AFP Antibodies) is a marker for Fanconi anemia (show PALB2 Antibodies); FANC proteins form multi-protein complexes with BRCA proteins and are involved in homologous DNA repair [review]

  10. These results suggested that LIMD1 (show LIMD1 Antibodies) is a novel BRCA2-interacting protein and is involved in the centrosome localization of BRCA2 and suppression of LIMD1 (show LIMD1 Antibodies), causing abnormal cell division in EC cells.

BRCA2 Antigen Profile

Antigen Summary

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

Alternative names and synonyms associated with BRCA2

  • breast cancer 2, early onset (BRCA2) antibody
  • breast cancer 2, early onset (brca2) antibody
  • breast cancer 2 (Brca2) antibody
  • breast cancer 2, early onset (Brca2) antibody
  • AI256696 antibody
  • AW045498 antibody
  • BRCA2 antibody
  • BRCC2 antibody
  • BROVCA2 antibody
  • FACD antibody
  • FAD antibody
  • FAD1 antibody
  • FANCB antibody
  • FANCD antibody
  • FANCD1 antibody
  • GLM3 antibody
  • PNCA2 antibody
  • RAB163 antibody

Protein level used designations for BRCA2

breast and ovarian cancer susceptibility protein 2 , breast cancer 2, early onset , breast cancer type 2 susceptibility protein-like , breast cancer type 2 susceptibility protein homolog , fanconi anemia group D1 protein homolog , BRCA1/BRCA2-containing complex, subunit 2 , breast and ovarian cancer susceptibility gene, early onset , breast cancer 2 tumor suppressor , breast cancer type 2 susceptibility protein , fanconi anemia group D1 protein , truncated breast and ovarian cancer susceptibility protein 2 , breast cancer 2, mutation 1, University of Wisconsin-Madison , breast cancer susceptibility protein 2

GENE ID SPECIES
100064578 Equus caballus
566758 Danio rerio
584780 Strongylocentrotus purpuratus
721981 Macaca mulatta
100397509 Callithrix jacchus
452526 Pan troglodytes
100038818 Xenopus (Silurana) tropicalis
100601625 Nomascus leucogenys
12190 Mus musculus
675 Homo sapiens
360254 Rattus norvegicus
374139 Gallus gallus
474180 Canis lupus familiaris
507069 Bos taurus
493878 Felis catus
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