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Browse our BRCA2 Proteins (BRCA2)

Full name:
Breast Cancer 2, Early Onset Proteins (BRCA2)
On are 2 Breast Cancer 2, Early Onset (BRCA2) Proteins from 2 different suppliers available. Additionally we are shipping BRCA2 Antibodies (91) and BRCA2 Kits (22) and many more products for this protein. A total of 118 BRCA2 products are currently listed.
list all proteins Gene Name GeneID UniProt
Mouse BRCA2 BRCA2 12190 P97929
BRCA2 675 P51587
Rat BRCA2 BRCA2 360254  

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BRCA2 Proteins (BRCA2) by Origin

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More Proteins for BRCA2 Interaction Partners

Zebrafish Breast Cancer 2, Early Onset (BRCA2) interaction partners

  1. Carcinogenesis in zebrafish with combined mutations in tp53 (show TP53 Proteins) and brca2 typically requires biallelic mutation or loss of at least one of these genes.

  2. The novel role of Brca2 in organizing the vertebrate egg nucleus may provide new insights into the origin of ovarian cancer

  3. critical roles for brca2 in ovarian development and tumorigenesis in reproductive tissues

Mouse (Murine) Breast Cancer 2, Early Onset (BRCA2) interaction partners

  1. Merit40 mutation exacerbated ICL-induced chromosome instability in the context of concomitant Brca2 deficiency but not in conjunction with Fancd2 mutation.

  2. Heterozygous and homozygous Brca2 mutation may lead to dysfunction in T cell populations.

  3. BRCA2 exon 27 domain maintains chromosomal integrity at both stalled and collapsed replication forks consistent with involvement in both replication fork maintenance and double strand break repair.

  4. we use a genetically engineered mouse model of BRCA2-associated hereditary breast cancer to study drug resistance to several types of chemotherapy and PARP (show PARP1 Proteins) inhibition.

  5. BRCA2-mediated sequestration of nuclear RAD51 (show RAD51 Proteins) serves to prevent inappropriate DNA interactions.

  6. BRCA2 directly represses the expression of IFN-related genes

  7. the models reveal novel aspects of cancer evolution in carriers of germline BRCA2 mutations, provide new insights into the tumour suppressive role of BRCA2

  8. genetic stability, and hematopoietic differentiation potential of gene-corrected Brca2(Delta) (27/) (Delta) (27) iPSCs, achievements and limitations in the application of current reprogramming approaches in hematopoietic stem cell therapy are also discussed.

  9. Results suggest that cellular levels of Brca2 and Rad51 (show RAD51 Proteins) are mutually dependent on each other, and that low levels of these proteins provide selective pressure for reduction of p53 (show TP53 Proteins), which permits cell growth

  10. BRCA2 accumulates DNA damage, which triggers checkpoint signalling and ARF activation

Human Breast Cancer 2, Early Onset (BRCA2) interaction partners

  1. BRCA2 Mutation is associated with Breast Cancer.

  2. No association between the thyroid hormones and breast cancer in BRCA1/2-mutation carriers was found

  3. the present systematic review collects and analyses the role of BRCA2 alterations to be used in early diagnosis of an inherited syndrome associated with familiar cancer and as a prognostic and predictive biomarker for the management of pancreatic cancer patients.

  4. Germline mutations in BRCA2 are not associated with reduced ovarian reserve as measured by Anti-Mullerian hormone (show AMH Proteins).

  5. For BRCA1 mutation carriers, cumulative estimates of developing cancer by age 70 vary by population, ranging from 40% to 85% for breast cancer and 10% to 59% for ovarian cancer. For BRCA2 mutation carriers, cumulative estimates of developing cancer are 45% to 57% for breast cancer and 11% to 18% for ovarian cancer.

  6. BRCA2 mutations strongly increase the in vitro- and in vivo-sensitivity of cancer cells towards TRAIL-R-mediated apoptosis.

  7. Data show that 11 breast cancer patients were mutated in BRCA1/2 genes, and 29 were not associated to BRCA1/2 mutations.

  8. Germline mutation in BRCA2 gene is associated with familial breast cancer.

  9. Study provides evidence that the prevalence of BRCA1 and BRCA2 mutations is high in triple-negative breast cancer patients.

  10. BRCA2 mutation is associated with Familial Pancreatic Cancer.

BRCA2 Protein Profile

Protein Summary

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

Alternative names and synonyms associated with BRCA2

  • breast cancer 2, early onset (BRCA2)
  • breast cancer 2, early onset (brca2)
  • breast cancer 2 (Brca2)
  • breast cancer 2, early onset (Brca2)
  • AI256696 protein
  • AW045498 protein
  • BRCA2 protein
  • BRCC2 protein
  • BROVCA2 protein
  • FACD protein
  • FAD protein
  • FAD1 protein
  • FANCB protein
  • FANCD protein
  • FANCD1 protein
  • GLM3 protein
  • PNCA2 protein
  • RAB163 protein

Protein level used designations for BRCA2

breast and ovarian cancer susceptibility protein 2 , breast cancer 2, early onset , breast cancer type 2 susceptibility protein-like , breast cancer type 2 susceptibility protein homolog , fanconi anemia group D1 protein homolog , BRCA1/BRCA2-containing complex, subunit 2 , breast and ovarian cancer susceptibility gene, early onset , breast cancer 2 tumor suppressor , breast cancer type 2 susceptibility protein , fanconi anemia group D1 protein , truncated breast and ovarian cancer susceptibility protein 2 , breast cancer 2, mutation 1, University of Wisconsin-Madison , breast cancer susceptibility protein 2

100064578 Equus caballus
566758 Danio rerio
584780 Strongylocentrotus purpuratus
721981 Macaca mulatta
100397509 Callithrix jacchus
452526 Pan troglodytes
100038818 Xenopus (Silurana) tropicalis
100601625 Nomascus leucogenys
12190 Mus musculus
675 Homo sapiens
360254 Rattus norvegicus
374139 Gallus gallus
474180 Canis lupus familiaris
507069 Bos taurus
493878 Felis catus
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