Browse our BRCA2 Proteins (BRCA2)

Full name:
Breast Cancer 2, Early Onset Proteins (BRCA2)
On www.antibodies-online.com are 2 Breast Cancer 2, Early Onset (BRCA2) Proteins from 2 different suppliers available. Additionally we are shipping BRCA2 Antibodies (89) and BRCA2 Kits (24) and many more products for this protein. A total of 118 BRCA2 products are currently listed.
Synonyms:
AI256696, AW045498, BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2, RAB163
list all proteins Gene Name GeneID UniProt
Mouse BRCA2 BRCA2 12190 P97929
BRCA2 675 P51587
Rat BRCA2 BRCA2 360254  

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BRCA2 Proteins (BRCA2) by Origin

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More Proteins for BRCA2 Interaction Partners

Zebrafish Breast Cancer 2, Early Onset (BRCA2) interaction partners

  1. Carcinogenesis in zebrafish with combined mutations in tp53 (show TP53 Proteins) and brca2 typically requires biallelic mutation or loss of at least one of these genes.

  2. The novel role of Brca2 in organizing the vertebrate egg nucleus may provide new insights into the origin of ovarian cancer

  3. critical roles for brca2 in ovarian development and tumorigenesis in reproductive tissues

Mouse (Murine) Breast Cancer 2, Early Onset (BRCA2) interaction partners

  1. we generated a Brca2 knock-in mouse model lacking exons 4-7 and demonstrated that these exons are dispensable for viability as well as tumor-free survival. This study provides the first in vivo evidence of the functional significance of a minor transcript of BRCA2 that can play a major role in the survival of humans who are homozygous for a clearly pathogenic mutation.

  2. we describe a genetic approach to examine the functional significance of the interaction between BRCA2 and PALB2 (show PALB2 Proteins) by generating a knock-in mouse model of Brca2 carrying a single amino acid change (Gly25Arg, Brca2G25R) that disrupts this interaction. In addition, we have combined Brca2G25R homozygosity as well as hemizygosity with Palb2 (show PALB2 Proteins) and Trp53 (show TP53 Proteins) heterozygosity .

  3. Merit40 mutation exacerbated ICL-induced chromosome instability in the context of concomitant Brca2 deficiency but not in conjunction with Fancd2 mutation.

  4. Heterozygous and homozygous Brca2 mutation may lead to dysfunction in T cell populations.

  5. BRCA2 exon 27 domain maintains chromosomal integrity at both stalled and collapsed replication forks consistent with involvement in both replication fork maintenance and double strand break repair.

  6. we use a genetically engineered mouse model of BRCA2-associated hereditary breast cancer to study drug resistance to several types of chemotherapy and PARP (show PARP1 Proteins) inhibition.

  7. BRCA2-mediated sequestration of nuclear RAD51 (show RAD51 Proteins) serves to prevent inappropriate DNA interactions.

  8. BRCA2 directly represses the expression of IFN-related genes

  9. the models reveal novel aspects of cancer evolution in carriers of germline BRCA2 mutations, provide new insights into the tumour suppressive role of BRCA2

  10. genetic stability, and hematopoietic differentiation potential of gene-corrected Brca2(Delta) (27/) (Delta) (27) iPSCs, achievements and limitations in the application of current reprogramming approaches in hematopoietic stem cell therapy are also discussed.

Human Breast Cancer 2, Early Onset (BRCA2) interaction partners

  1. These findings suggest that R2787H variant of BRCA2 could have potential functional impact.

  2. Even if a BRCA2 mutation is already identified within a family, the presence of early onset breast cancer affected non-carriers hampers accurate risk estimates for both mutation carriers and other negative family members.

  3. cyclin D1 (show CCND1 Proteins) and other cyclins such as cyclin A (show CCNA2 Proteins) regulates DNA integrity through RAD51 (show RAD51 Proteins) interaction with the BRCA2 C-terminal domain

  4. polygenic risk scores may provide informative cancer risk stratification for male carriers of BRCA1/2 mutations that might enable these men and their physicians to make informed decisions on the type and timing of breast and prostate cancer risk management.

  5. This study detected monoallelic L1053X mutation causing the same stop codon in BRCA2 protein sequence at the same position in four Sudanese female breast cancer patients out of nine from different families.

  6. Being a male BRCA1 or a BRCA2 mutation carrier or even being clinically defined as having high cancer risk with no known BRCA mutation in men is not associated with any clinically significant risk for developing this rare entity.

  7. A patient with an ampulla of Vater carcinoma was incidentally found to carry the BRCA2 c.156_157insAlu mutation. Further testing of a consecutive series of additional 15 ampullary carcinomas for BRCA1/BRCA2 mutations using a combination of direct founder mutation testing and full gene analysis with next generation sequencing. BRCA2 mutations were observed with a frequency of 14.3% in ampulla of Vater carcinomas.

  8. data from our systematic review and meta-analysis suggests a causal relationship between germline BRCA1/2-pathogenic mutations and the development of Uterine serous carcinoma.

  9. study demonstrates that the individual and combined expression patterns of the DDR (show DDR1 Proteins) molecules PARP1 (show PARP1 Proteins), gammaH2AX (show H2AFX Proteins), BRCA1, and BRCA2 could be predictive of the prognosis of STS (show STS Proteins) patients and suggests that controlling the activity of these DDR (show DDR1 Proteins) molecules could be employed in new therapeutic stratagems for the treatment of STS (show STS Proteins)

  10. radiosensitization was evaluated using the glioblastoma cell line, U87MG-E6, which harbors inactivated p53 (show TP53 Proteins), in comparison with the cell line, HCT116 p53 (show TP53 Proteins) (-/-). We conclude that radiosensitization by arsenite is related to ROS (show ROS1 Proteins) and BRCA2 function.

BRCA2 Protein Profile

Protein Summary

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

Alternative names and synonyms associated with BRCA2

  • breast cancer 2, early onset (BRCA2)
  • breast cancer 2, early onset (brca2)
  • breast cancer 2 (Brca2)
  • breast cancer 2, early onset (Brca2)
  • AI256696 protein
  • AW045498 protein
  • BRCA2 protein
  • BRCC2 protein
  • BROVCA2 protein
  • FACD protein
  • FAD protein
  • FAD1 protein
  • FANCB protein
  • FANCD protein
  • FANCD1 protein
  • GLM3 protein
  • PNCA2 protein
  • RAB163 protein

Protein level used designations for BRCA2

breast and ovarian cancer susceptibility protein 2 , breast cancer 2, early onset , breast cancer type 2 susceptibility protein-like , breast cancer type 2 susceptibility protein homolog , fanconi anemia group D1 protein homolog , BRCA1/BRCA2-containing complex, subunit 2 , breast and ovarian cancer susceptibility gene, early onset , breast cancer 2 tumor suppressor , breast cancer type 2 susceptibility protein , fanconi anemia group D1 protein , truncated breast and ovarian cancer susceptibility protein 2 , breast cancer 2, mutation 1, University of Wisconsin-Madison , breast cancer susceptibility protein 2

GENE ID SPECIES
100064578 Equus caballus
566758 Danio rerio
584780 Strongylocentrotus purpuratus
721981 Macaca mulatta
100397509 Callithrix jacchus
452526 Pan troglodytes
100038818 Xenopus (Silurana) tropicalis
100601625 Nomascus leucogenys
12190 Mus musculus
675 Homo sapiens
360254 Rattus norvegicus
374139 Gallus gallus
474180 Canis lupus familiaris
507069 Bos taurus
493878 Felis catus
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