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Browse our MutY Homolog (E. Coli) Proteins (MUTYH)

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MutY Homolog (E. Coli) Proteins (MUTYH)
On are 7 MutY Homolog (E. Coli) (MUTYH) Proteins from 5 different suppliers available. Additionally we are shipping MutY Homolog (E. Coli) Antibodies (98) and MutY Homolog (E. Coli) Kits (9) and many more products for this protein. A total of 122 MutY Homolog (E. Coli) products are currently listed.
5730495A01Rik, CYP2C, MGC145569, MUTYH, Mutyha, Mutyhalpha, Mutyhb, Mutyhbeta, Mutyhc, Myh
list all proteins Gene Name GeneID UniProt
MUTYH 70603 Q99P21
MUTYH 170841 Q8R5G2

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MutY Homolog (E. Coli) Proteins (MUTYH) by Origin

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More Proteins for MutY Homolog (E. Coli) Interaction Partners

Horse (Equine) MutY Homolog (E. Coli) (MUTYH) interaction partners

  1. qPCR analysis of cDNA from the cerebella of affected and unaffected horses suggested that MUTYH expression is down-regulated in affected horses.

Human MutY Homolog (E. Coli) (MUTYH) interaction partners

  1. Authors identified 266 probands (91% Caucasians) with a MUTYH mutation (41 biallelic and 225 monoallelic) from the Colon Cancer Family Registry. Mutation status, sex, age and histories of cancer from their 1,903 first- and 3,255 second-degree relatives were analyzed using modified segregation analysis conditioned on the ascertainment criteria.

  2. A high heterogeneity of MUTYH variants and a high rate of variants of unknown significance were identified in a cohort of Italian patients with suspected MUTYH-associated polyposis. Genotype-phenotype analysis suggests that the p.Glu480del variant is associated with a severe phenotype.

  3. Mutational signature analysis identifies MUTYH deficiency in colorectal cancers and adrenocortical carcinomas.

  4. report of the results of functional evaluation of nine missense-type MUTYH variant proteins in the Japanese population; findingssuggest that p.N238S and p.R247G are likely to be pathogenic alleles for MUTYH-associated polyposis

  5. Case Report: MUTYH-associated polyposis with cutaneous sebaceous lesions.

  6. The IVS10-2A>G MUTYH heterozygote variant might add to the risk of developing germline APC (show APC Proteins) mutation negative colorectal adenomatous polyposis in Japanese patients.

  7. MutY homolog Y165C and G382D mutations are not associated with cholangiocarinoma.

  8. the age at onset of polyposis was significantly delayed for biallelic MUTYH mutation carriers as compared to patients with an APC (show APC Proteins) mutation

  9. A mutation in both a MUTYH and either a MLH1 (show MLH1 Proteins), MSH2 (show MSH2 Proteins) and PMS2 (show PMS2 Proteins) gene mutation is associated with colorectal cancer.

  10. Expression of APC (show APC Proteins) is decreased in mutation negative cases and this appears to be a promising indicator of FAP predisposition, while for MUTYH gene, mutation is associated to reduced mRNA expression.

Mouse (Murine) MutY Homolog (E. Coli) (MUTYH) interaction partners

  1. Ogg1 (show OGG1 Proteins) and Mutyh regulate hippocampal gene expression related to cognition and behavior, suggesting a role for the glycosylases in regulating adaptive behavior.

  2. MUTYH loss is associated with an increase in inflammation associated colorectal cancer risk, which involves immunosuppression and altered inflammatory response.

  3. Results show that MYH is a vital DNA repair enzyme (show LIG4 Proteins) that protects cells from oxidative DNA damage and is critical for a proper cellular response to DNA damage.

  4. a 5-methylcytosine glycosylase activity for the murine DNA base excision repair enzyme Myh is described and shown that it is critically involved in remodeling the IL-2 (show IL2 Proteins) Promoter for transcription.

  5. Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1 (show OGG1 Proteins), Neil1 (show NEIL1 Proteins), Mutyh and Xrcc1 (show XRCC1 Proteins) in the brain of adult offspring.

  6. The action of MUTYH, which initiates excision repair of adenine opposite 8-oxoG, triggers neurodegeneration in mice.

  7. OGG1 (show OGG1 Proteins) and MYH appear to be dispensable for antimutator function in mitochondria.

  8. Mutyh plays a major role in maintaining intestinal integrity by affecting the inflammatory response.

  9. Aim of this study was to characterize the biological effects, in a mammalian cell background, of human MUTYH mutations identified in MUTYH-associated polyposis patients

  10. Replication-associated repair of adenine:8-oxoguanine mispairs by MYH

MutY Homolog (E. Coli) (MUTYH) Protein Profile

Protein Summary

This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with MutY Homolog (E. Coli) (MUTYH)

  • mutY homolog (E. coli) (MUTYH)
  • mutY homolog (MUTYH)
  • mutY homolog (mutyh)
  • mutY homolog (LOC100373318)
  • mutY homolog (E. coli) (Mutyh)
  • 5730495A01Rik protein
  • CYP2C protein
  • MGC145569 protein
  • MUTYH protein
  • Mutyha protein
  • Mutyhalpha protein
  • Mutyhb protein
  • Mutyhbeta protein
  • Mutyhc protein
  • Myh protein

Protein level used designations for MutY Homolog (E. Coli) Proteins (MUTYH)

mutY homolog (E. coli) , A/G-specific adenine DNA glycosylase , A/G-specific adenine DNA glycosylase-like , mutY homolog , adenine-DNA glycosylase , mMYH , mutY homolog alpha , the full-length form type A, 5' region , rMYH

424594 Gallus gallus
456539 Pan troglodytes
482515 Canis lupus familiaris
513051 Bos taurus
100052596 Equus caballus
100397524 Callithrix jacchus
100465330 Ailuropoda melanoleuca
100513867 Sus scrofa
705651 Macaca mulatta
780292 Xenopus (Silurana) tropicalis
100373318 Saccoglossus kowalevskii
4595 Homo sapiens
70603 Mus musculus
170841 Rattus norvegicus
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