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OGG1 activity might be inhibited during postreplicative mismatch repair.
Results show ogg1 is fundamentally required for protecting the developing brain, which may be helpful in understanding the aetiology of congenital brain deficits.
work demonstrates the requirement of ogg1 in cardiac progenitors and heart development in zebrafish
Arabidopsis cells use both FPG and OGG1 to repair 8-oxoG in a pathway that requires ZDP and ARP (show ARFRP1 Proteins) in downstream steps.
Overexpression of OGG1 enhances seed longevity and abiotic stress tolerance.
Results show that some polymorphic variants in XRCC1 (show XRCC1 Proteins) and OGG1 are associated with increased DNA damage in Alzheimer's Disease.
The excision of the 8-oxoguanine base with DeltaG# = 16.1 kcal/mol (show DUOXA1 Proteins) proceeded via substitution of the C1-N9 N-glycosidic bond with an H-N9 bond where the negative charge on the oxoG base and the positive charge on the ribose were compensated in a concerted manner by NH3+(Lys249) and CO2-(Asp268), respectively.
The interaction of OGG1 and XRCC1 (show XRCC1 Proteins) DNA repair polymorphisms and arsenic exposure enhances telomeric DNA damage.
Polymorphisms of OGG1 and MTHFR (show MTHFR Proteins) genes are associated with ARC (show NOL3 Proteins) susceptibility
Reduced MUTYH (show MUTYH Proteins), MTH1 (show NUDT1 Proteins), and OGG1 expression and TP53 (show TP53 Proteins) mutations occur in diffuse-type adenocarcinoma of gastric cardia.
These results together, points to a new paradigm about the role of DNA damage and repair by OGG1 in aging and age-associated disease processes.
DNA repair protein (show ATRIP Proteins) OGG1 bound to its substrate is coupled to DNA occupancy of NF-kappaB (show NFKB1 Proteins) and functions in epigenetic regulation of gene expression.
Study shows increased level of 8-oxoG and decreased OGG1 protein in the serum of patients with Alzheimer's disease, suggesting that oxidative damage to DNA and a decreased DNA glycosylase are involved in the etiopathology of Alzheimer's disease
APE1 (show APEX1 Proteins) Accelerates turnover of OGG1 by preventing retrograde binding to the abasic-site product.
find that the energetic nature of the observed binding free energies of human 8-oxoguanine DNA glycosylase (hOGG1) and human uracil DNA glycosylase (show UNG Proteins) (hUNG) for undamaged DNA are derived from different sources. Although hOGG1 uses primarily nonelectrostatic binding interactions with nonspecific DNA, hUNG uses a salt-dependent electrostatic binding mode
OGG1 plays a role in an LSD1 (show KDM1A Proteins)-dependent pathway of LPS (show TLR4 Proteins)-induced macrophage activation in mice.
These findings demonstrate that OGG-1 negatively regulates inflammatory cytokine release by coordinating molecular interaction with the autophagic pathway in hyperoxia-induced lung injury.
results implicate hyperglycemia-induced O-GlcNAcylation of Ogg1 in increased mtDNA damage and, therefore, provide a new plausible biochemical mechanism for diabetic cardiomyopathy.
OGG1 plays a protective role in atherosclerosis by preventing excessive inflammasome activation.
OGG1 acts as a STAT1 (show STAT1 Proteins) coactivator and has transcriptional activity in the presence of endotoxin
Ogg1 and Mutyh (show MUTYH Proteins) regulate hippocampal gene expression related to cognition and behavior, suggesting a role for the glycosylases in regulating adaptive behavior.
Data suggest that OGG1 plays a vital role in the protection of DNA bases from oxidative damage induced by radiofrequency electromagnetic radiation.
Deletion of one or both alleles of ogg1 in mice does increase susceptibility to the toxic effects of aflatoxin B1.
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
8-oxoguanine DNA glycosylase
, N-glycosylase/DNA lyase
, 8-OXOGUANINE DNA GLYCOSYLASE
, DNA-formamidopyrimidine glycosylase
, 8-oxoguanine-DNA glycosylase 1
, 8-oxoguanine DNA-glycosylase 1
, n-glycosylase/DNA lyase-like
, 8-hydroxyguanine DNA glycosylase
, AP lyase
, DNA-apurinic or apyrimidinic site lyase
, OGG1 type 1f