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Browse our OGG1 Proteins (OGG1)

Full name:
8-Oxoguanine DNA Glycosylase Proteins (OGG1)
On are 15 8-Oxoguanine DNA Glycosylase (OGG1) Proteins from 7 different suppliers available. Additionally we are shipping OGG1 Antibodies (146) and OGG1 Kits (18) and many more products for this protein. A total of 186 OGG1 products are currently listed.
8-oxoguanine-DNA glycosylase 1, 19.m02329, ARABIDOPSIS 8-OXOGUANINE-DNA GLYCOSYLASE 1, ATOGG1, DDBDRAFT_0184479, DDBDRAFT_0233024, DDB_0184479, DDB_0233024, F8K7.14, F8K7_14, HMMH, HOGG1, Mmh, MUTM, ogg1, OGH1, Tb04.1H19.930, zgc:158858
list all proteins Gene Name GeneID UniProt
OGG1 4968 O15527
Rat OGG1 OGG1 81528 O70249
OGG1 18294 O08760

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OGG1 Proteins (OGG1) by Origin

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Top referenced OGG1 Proteins

  1. Human OGG1 Protein expressed in Escherichia coli (E. coli) - ABIN667178 : Mirbahai, Kershaw, Green, Hayden, Meldrum, Hodges: Use of a molecular beacon to track the activity of base excision repair protein OGG1 in live cells. in DNA repair 2010 (PubMed)
    Show all 2 references for ABIN667178

More Proteins for OGG1 Interaction Partners

Xenopus laevis 8-Oxoguanine DNA Glycosylase (OGG1) interaction partners

  1. OGG1 activity might be inhibited during postreplicative mismatch repair.

Zebrafish 8-Oxoguanine DNA Glycosylase (OGG1) interaction partners

  1. Results show ogg1 is fundamentally required for protecting the developing brain, which may be helpful in understanding the aetiology of congenital brain deficits.

  2. work demonstrates the requirement of ogg1 in cardiac progenitors and heart development in zebrafish

Arabidopsis thaliana 8-Oxoguanine DNA Glycosylase (OGG1) interaction partners

  1. Arabidopsis cells use both FPG and OGG1 to repair 8-oxoG in a pathway that requires ZDP and ARP (show ARFRP1 Proteins) in downstream steps.

  2. Overexpression of OGG1 enhances seed longevity and abiotic stress tolerance.

Human 8-Oxoguanine DNA Glycosylase (OGG1) interaction partners

  1. DNA repair protein (show ATRIP Proteins) OGG1 bound to its substrate is coupled to DNA occupancy of NF-kappaB (show NFKB1 Proteins) and functions in epigenetic regulation of gene expression.

  2. Study shows increased level of 8-oxoG and decreased OGG1 protein in the serum of patients with Alzheimer's disease, suggesting that oxidative damage to DNA and a decreased DNA glycosylase are involved in the etiopathology of Alzheimer's disease

  3. APE1 (show APEX1 Proteins) Accelerates turnover of OGG1 by preventing retrograde binding to the abasic-site product.

  4. find that the energetic nature of the observed binding free energies of human 8-oxoguanine DNA glycosylase (hOGG1) and human uracil DNA glycosylase (show UNG Proteins) (hUNG) for undamaged DNA are derived from different sources. Although hOGG1 uses primarily nonelectrostatic binding interactions with nonspecific DNA, hUNG uses a salt-dependent electrostatic binding mode

  5. The Cys/Cys (show DNAJC5 Proteins) genotype of hOGG1 correlated strongly with the risk of developing ischemic cardiomyopathy.

  6. Polymorphisms of human 8-oxoguanine DNA glycosylase 1 and 8-hydroxydeoxyguanosine increase susceptibility to arsenic methylation capacity-related urothelial carcinoma.

  7. Polymorphisms in OGG1 gene is associated with gastrointestinal stromal tumours.

  8. Inherited OGG1 single nucleotide polymorphisms in Base-excision repair pathway are important determinants of oropharyngeal squamous cell carcinoma and predictors of patient outcomes.

  9. OGG1 and APE1 (show APEX1 Proteins) polymorphisms are associated with stage- and sex-specific risk of colorectal carcinoma in the Taiwanese population.

  10. The data of this study showed that OGG1 Ser326Cys and XRCC1 (show XRCC1 Proteins) Arg399Gln gene polymorphisms had impacts on the development of stroke.

Mouse (Murine) 8-Oxoguanine DNA Glycosylase (OGG1) interaction partners

  1. results implicate hyperglycemia-induced O-GlcNAcylation of Ogg1 in increased mtDNA damage and, therefore, provide a new plausible biochemical mechanism for diabetic cardiomyopathy.

  2. DNA repair protein (show ATRIP Proteins) OGG1 bound to its substrate is coupled to DNA occupancy of NF-kappaB (show NFKB1 Proteins) and functions in epigenetic regulation of gene expression.

  3. OGG1 plays a protective role in atherosclerosis by preventing excessive inflammasome activation.

  4. OGG1 acts as a STAT1 (show STAT1 Proteins) coactivator and has transcriptional activity in the presence of endotoxin

  5. Ogg1 and Mutyh (show MUTYH Proteins) regulate hippocampal gene expression related to cognition and behavior, suggesting a role for the glycosylases in regulating adaptive behavior.

  6. Data suggest that OGG1 plays a vital role in the protection of DNA bases from oxidative damage induced by radiofrequency electromagnetic radiation.

  7. Deletion of one or both alleles of ogg1 in mice does increase susceptibility to the toxic effects of aflatoxin B1.

  8. OGG1- DNA base excision repair plays a role in various biological processes that may benefit the host, but when in excess (show RCC1 Proteins) could be implicated in disease and/or aging processes.

  9. Oxidative damage and Ogg1 deficient background exacerbate repair deficiencies.. Overexpression of the arsenic metabolizing enzyme As3mt (show AS3MT Proteins) acts as adaptive mechanism.

  10. rise in the intracellular 8-oxoG base levels increases the proportion of GTP-bound Rac1

OGG1 Protein Profile

Protein Summary

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.

Alternative names and synonyms associated with OGG1

  • 8-oxoguanine DNA glycosylase (OGG1)
  • 8-oxoguanine DNA glycosylase (ogg1)
  • 8-oxoguanine-DNA glycosylase 1 (OGG1)
  • 8-oxoguanine-DNA-glycosylase (CAC2707)
  • 8-oxoguanine DNA glycosylase (BBOV_I004290)
  • 8-oxoguanine DNA glycosylase (Smp_074010.1)
  • 8-oxoguanine DNA-glycosylase (ogg1)
  • N-glycosylase/DNA lyase (ogg1)
  • 8-oxoguanine DNA glycosylase (Tb927.4.2480)
  • 8-oxoguanine DNA glycosylase (Ogg1)
  • 8-oxoguanine DNA-glycosylase 1 (Ogg1)
  • 8-oxoguanine-DNA glycosylase 1 protein
  • 19.m02329 protein
  • ATOGG1 protein
  • DDBDRAFT_0184479 protein
  • DDBDRAFT_0233024 protein
  • DDB_0184479 protein
  • DDB_0233024 protein
  • F8K7.14 protein
  • F8K7_14 protein
  • HMMH protein
  • HOGG1 protein
  • Mmh protein
  • MUTM protein
  • ogg1 protein
  • OGH1 protein
  • Tb04.1H19.930 protein
  • zgc:158858 protein

Protein level used designations for OGG1

8-oxoguanine DNA glycosylase , N-glycosylase/DNA lyase , 8-OXOGUANINE DNA GLYCOSYLASE , 8-oxoguanine-DNA-glycosylase , DNA-formamidopyrimidine glycosylase , 8-oxoguanine-DNA glycosylase 1 , 8-oxoguanine DNA-glycosylase 1 , n-glycosylase/DNA lyase-like , 8-hydroxyguanine DNA glycosylase , AP lyase , DNA-apurinic or apyrimidinic site lyase , OGG1 type 1f

460152 Pan troglodytes
700481 Macaca mulatta
733253 Xenopus laevis
771001 Gallus gallus
791194 Danio rerio
838775 Arabidopsis thaliana
859629 Encephalitozoon cuniculi GB-M1
1118890 Clostridium acetobutylicum ATCC 824
4837452 Scheffersomyces stipitis CBS 6054
5477294 Babesia bovis T2Bo
8346251 Schistosoma mansoni
8628782 Dictyostelium discoideum AX4
9329243 Arabidopsis lyrata subsp. lyrata
100195518 Salmo salar
100380072 Xenopus (Silurana) tropicalis
100432840 Pongo abelii
3656775 Trypanosoma brucei brucei strain 927/4 GUTat10.1
4968 Homo sapiens
81528 Rattus norvegicus
484666 Canis lupus familiaris
520497 Bos taurus
18294 Mus musculus
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