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Human OGG1 Protein expressed in Escherichia coli (E. coli) - ABIN667178
Mirbahai, Kershaw, Green, Hayden, Meldrum, Hodges: Use of a molecular beacon to track the activity of base excision repair protein OGG1 in live cells. in DNA repair 2010
Show all 2 references for ABIN667178
OGG1 activity might be inhibited during postreplicative mismatch repair.
Results show ogg1 is fundamentally required for protecting the developing brain, which may be helpful in understanding the aetiology of congenital brain deficits.
work demonstrates the requirement of ogg1 in cardiac progenitors and heart development in zebrafish
Arabidopsis cells use both FPG and OGG1 to repair 8-oxoG in a pathway that requires ZDP and ARP (show ARFRP1 Proteins) in downstream steps.
Overexpression of OGG1 enhances seed longevity and abiotic stress tolerance.
OGG1 and APE1 (show APEX1 Proteins) polymorphisms are associated with stage- and sex-specific risk of colorectal carcinoma in the Taiwanese population.
The data of this study showed that OGG1 Ser326Cys and XRCC1 (show XRCC1 Proteins) Arg399Gln gene polymorphisms had impacts on the development of stroke.
remodeling by acetyl (show STAT1 Proteins)ation and dimethylation of lysine-14 and -4 residues of histone H3. In addition, OGG1 acts as a STAT1 coactivator and has transcriptional activity in the presence of endotoxin. The data presented here identifies a novel mechanism, and may provide new therapeutic strategies for the treatment of endotoxin-mediated inflammatory diseases.
The frequency of OGG1 Ser326Cys polymorphisms was not significantly altered in Chinese patients with senile cataracts.
OGG1 Ser (show SIGLEC1 Proteins)/Cys (show DNAJC5 Proteins) and Ser (show SIGLEC1 Proteins)/Cys + Cys/Cys (show DNAJC5 Proteins) genotypes had higher multiple sclerosis risk.
study points at the elucidation of a possible association of Rheumatoid arthritis (RA) with Ser326Cys in OGG1 Arg194Trp and Arg399Gln polymorphisms of XRCC1 (show XRCC1 Proteins) using a sample size of 100 patients and 100 controls from a Pakistani population
Polymorphisms in OGG1 do not contribute to development of non-small cell lung cancer in Brazilian patients.
our study in the Han Chinese population, along with the meta-analysis, failed to confirm the association of the hOGG1 gene Ser326Cys polymorphism with gastric cancer risk, even across different ethnic populations.
Our results suggest that the circadian modulation of 8-oxoG DNA damage repair, according to a variation of Ogg1 expression, could render humans less susceptible to accumulate 8-oxoG DNA damage in the morning hours.
XPC (show XPC Proteins) protein is required for OGG1 activity, but XPC (show XPC Proteins) does not interacts physically with OGG1.
OGG1 acts as a STAT1 (show STAT1 Proteins) coactivator and has transcriptional activity in the presence of endotoxin
Ogg1 and Mutyh (show MUTYH Proteins) regulate hippocampal gene expression related to cognition and behavior, suggesting a role for the glycosylases in regulating adaptive behavior.
Data suggest that OGG1 plays a vital role in the protection of DNA bases from oxidative damage induced by radiofrequency electromagnetic radiation.
Deletion of one or both alleles of ogg1 in mice does increase susceptibility to the toxic effects of aflatoxin B1.
OGG1- DNA base excision repair plays a role in various biological processes that may benefit the host, but when in excess (show RCC1 Proteins) could be implicated in disease and/or aging processes.
Oxidative damage and Ogg1 deficient background exacerbate repair deficiencies.. Overexpression of the arsenic metabolizing enzyme As3mt (show AS3MT Proteins) acts as adaptive mechanism.
rise in the intracellular 8-oxoG base levels increases the proportion of GTP-bound Rac1
8-Oxo-7,8-dihydroguanine repair is a lifetime process suggesting that, via Rho GTPase (show RACGAP1 Proteins), OGG1 could be involved in the cytoskeletal changes and organ remodeling observed in various chronic diseases.
Expression of OGG1 and APEX1 (show APEX1 Proteins) was decreased at 3h after last exposure to Aroclor 1254 and only the expression level of APEX1 (show APEX1 Proteins) was recovered at 24-h after, so inhibition of DNA repair can be a potential mode of action of Aroclor 1254 gonadal toxicity.
These findings suggest an important role for AEC mtDNA integrity maintained by OGG1 in the pathogenesis of pulmonary fibrosis that may represent a novel therapeutic target.
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined.
8-oxoguanine DNA glycosylase
, N-glycosylase/DNA lyase
, 8-OXOGUANINE DNA GLYCOSYLASE
, DNA-formamidopyrimidine glycosylase
, 8-oxoguanine-DNA glycosylase 1
, 8-oxoguanine DNA-glycosylase 1
, n-glycosylase/DNA lyase-like
, 8-hydroxyguanine DNA glycosylase
, AP lyase
, DNA-apurinic or apyrimidinic site lyase
, OGG1 type 1f