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RAD50 Homolog (S. Cerevisiae) ELISA Kits (RAD50)
On are 9 RAD50 Homolog (S. Cerevisiae) (RAD50) ELISA Kits from 4 different suppliers available. Additionally we are shipping RAD50 Antibodies (128) and RAD50 Proteins (7) and many more products for this protein. A total of 149 RAD50 products are currently listed.
6339, ATRAD50, CG6339, Dmel\\CG6339, Dmrad50, DNA REPAIR-RECOMBINATION PROTEIN, F22D22.28, F22D22_28, hRad50, Mrell, NBSLD, Rad50, Rad50l, RAD502, SPAP4C9.01c
list all ELISA KIts Gene Name GeneID UniProt
RAD50 10111 Q92878
RAD50 19360  
Rat RAD50 RAD50 64012 Q9JIL8

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Fruit Fly (Drosophila melanogaster) RAD50 Homolog (S. Cerevisiae) (RAD50) interaction partners

  1. Study identified a stringent requirement for Mre11 (show MRE11A ELISA Kits)-Rad50-Nbs (show NLRP2 ELISA Kits) (MRN) function in telomere protection during early embryonic development.

Xenopus laevis RAD50 Homolog (S. Cerevisiae) (RAD50) interaction partners

  1. MRN (Mre11 (show MRE11A ELISA Kits), Rad50, and Nbs1 (show NLRP2 ELISA Kits)) complex, CtIP (show RBBP8 ELISA Kits), and BRCA1 are required for both the removal of Top2 (show TOP2 ELISA Kits)-DNA adducts and the subsequent resection of Top2 (show TOP2 ELISA Kits)-adducted DSB ends.

  2. MRN (MRE11 (show MRE11A ELISA Kits)-RAD50-NBS1 (show NLRP2 ELISA Kits)) complex has role in ATR (show ATR ELISA Kits) activation via TOPBP1 (show TOPBP1 ELISA Kits) recruitment.

  3. Results indicate a role for the X. laevis Mre11 (show MRE11A ELISA Kits)/Rad50/Nbs1 (show NLRP2 ELISA Kits) complex in microhomology-mediated end joining.

  4. These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM (show ATM ELISA Kits) promotes the TopBP1 (show TOPBP1 ELISA Kits)-dependent activation of ATR (show ATR ELISA Kits)-ATRIP (show ATRIP ELISA Kits) in response to double-stranded DNA breaks.

  5. suggests that Mre11 (show MRE11A ELISA Kits)-Rad50-Nbs1 (show NLRP2 ELISA Kits) inactivation participates in the down-regulation of damage signaling during checkpoint recovery following double-strand breaks repair.

Arabidopsis thaliana RAD50 Homolog (S. Cerevisiae) (RAD50) interaction partners

  1. Data show that the product of the PHS1 (show PTGS1 ELISA Kits) gene is a cytoplasmic protein that functions by controlling transport of RAD50 from cytoplasm to the nucleus.

  2. The protective role of Rad50 protein on shortened telomeres results from its action in constraining recombination to sister chromatids and thus avoiding end-to-end interactions.

Human RAD50 Homolog (S. Cerevisiae) (RAD50) interaction partners

  1. The results illuminate the important role of Nbs1 (show NBN ELISA Kits) and CtIP (show RBBP8 ELISA Kits) in determining the substrates and consequences of human Mre11 (show MRE11A ELISA Kits)/Rad50 nuclease (show DCLRE1C ELISA Kits) activities on protein-DNA lesions.

  2. identification of a novel association for longevity in the RAD50/IL13 (show IL13 ELISA Kits) region on chromosome 5q31.1; the lead SNP rs2706372 is located in the intronic region of the RAD50 gene and is in strong linkage disequilibrium with other associated SNPs close to IL13 (show IL13 ELISA Kits) and IL5 (show IL5 ELISA Kits)

  3. the structure of the human Rad50 hook and coiled-coil domains, was determined.

  4. although Mre11 (show MRE11A ELISA Kits) is required for efficient HR-dependent repair of ionizing-radiation-induced DSBs, Mre11 (show MRE11A ELISA Kits) is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines.

  5. The high expression of MRE11 (show MRE11A ELISA Kits)-RAD50-NBS1 (show NBN ELISA Kits) complex constituents could be a predictor for poor prognosis and chemoresistance in gastric cancer

  6. Germline mutation in RAD50 gene is associated with familial breast cancer.

  7. The MRN complex is essential to restrain MYCN (show MYCN ELISA Kits)-induced replication stress during neural cell proliferation.

  8. study identified the copy number deletion of RAD50 as a candidate marker for survival

  9. Lack of association between RAD50-IL13 polymorphisms and pediatric asthma susceptibility in Northeastern Han Chinese

  10. we present an in-depth genomic and functional genetic analysis identifying RAD50 hypomorphism as a contributing factor to a curative response to systemic combination therapy in a patient with recurrent, metastatic small-cell cancer.

Mouse (Murine) RAD50 Homolog (S. Cerevisiae) (RAD50) interaction partners

  1. The authors demonstrate that ATM (show ATM ELISA Kits) can be activated by DNA double-strand breaks in the absence of the Mre11 (show MRE11A ELISA Kits)-Rad50-NBS1 (show NBN ELISA Kits) (MRN) sensor complex.

  2. Rad50 hook domain strongly influences Mre11 (show MRE11A ELISA Kits) complex-dependent DDR (show DDR1 ELISA Kits) signaling, tissue homeostasis, and tumorigenesis.

  3. RAD50, DNA-PKcs (show PRKDC ELISA Kits) kinase activity, and transcription context are each important to limit incorrect end use during EJ repair of multiple DSBs, but each has distinct roles during repair events requiring end processing

  4. Data show that CS-mediated SCC (show CYP11A1 ELISA Kits) lethality was mitigated in irradiated gain-of-function Rad50(s/s) mice, and epistasis studies order Rad50 upstream of Mre11 (show MRE11A ELISA Kits).

  5. MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.

  6. Rad50 mutant mice (Rad50(S/S) mice) exhibited growth defects and cancer predisposition.

  7. the RAD50 LCR has a complex and dual role in Th1 (show HAND1 ELISA Kits) and Th2 differentiation, communicating early T cell antigen receptor and cytokine signals to the IL-4 (show IL4 ELISA Kits)/IL-13 (show IL13 ELISA Kits) locus in both differentiating cell types

  8. enhancer region with four DNase I (show DNASE1 ELISA Kits) hypersensitive clusters, three of which are highly conserved and predominantly expressed in Th2 cells

  9. The MRE11 (show MRE11A ELISA Kits)-RAD50-Nijmegen breakage syndrome 1 (NBS1 (show NLRP2 ELISA Kits) [MRN]) complex accumulates at sites of DNA double-strand breaks (DSBs) in microscopically discernible nuclear foci.

  10. depletion of Rad50 in cultured cells caused extensive DNA damage & death within 3 to 5 days of Rad50 deletion; this was not associated with gross telomere dysfunction, suggesting that telomeric functions of the Mre11 (show MRE11A ELISA Kits) complex are not required for viability

RAD50 Antigen Profile

Antigen Summary

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.

Alternative names and synonyms associated with RAD50

  • RAD50 homolog (S. cerevisiae) (RAD50) Elisa Kit
  • CG6339 gene product from transcript CG6339-RE (rad50) Elisa Kit
  • RAD50 homolog (rad50) Elisa Kit
  • rad50 (rad50) Elisa Kit
  • DNA repair protein RAD50 (rad50) Elisa Kit
  • Rad50p (RAD50) Elisa Kit
  • DNA repair protein Rad50 (rad50) Elisa Kit
  • RAD50 recombination protein (RAD50) Elisa Kit
  • Rad50 DNA repair/recombination protein (Rad50) Elisa Kit
  • DNA repair protein RAD50 (RAD50) Elisa Kit
  • Protein RAD-50 (rad-50) Elisa Kit
  • RAD50 homolog (S. cerevisiae) (Rad50) Elisa Kit
  • 6339 Elisa Kit
  • ATRAD50 Elisa Kit
  • CG6339 Elisa Kit
  • Dmel\\CG6339 Elisa Kit
  • Dmrad50 Elisa Kit
  • F22D22.28 Elisa Kit
  • F22D22_28 Elisa Kit
  • hRad50 Elisa Kit
  • Mrell Elisa Kit
  • NBSLD Elisa Kit
  • Rad50 Elisa Kit
  • Rad50l Elisa Kit
  • RAD502 Elisa Kit
  • SPAP4C9.01c Elisa Kit

Protein level used designations for RAD50

DNA repair protein RAD50 , CG6339-PD , CG6339-PE , rad50-PD , rad50-PE , RAD50 homolog (S. cerevisiae) , RAD50 homolog , GLEAN_15093 , Rad50p , Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining , Rad50 DNA repair/recombination protein , DNA repair protein RAD50-like , mRad50

788127 Bos taurus
100063198 Equus caballus
100328725 Oryctolagus cuniculus
37564 Drosophila melanogaster
416329 Gallus gallus
462054 Pan troglodytes
474674 Canis lupus familiaris
495064 Xenopus laevis
658288 Tribolium castaneum
726642 Apis mellifera
779556 Xenopus (Silurana) tropicalis
855471 Saccharomyces cerevisiae S288c
2541635 Schizosaccharomyces pombe 972h-
7200598 Phaeodactylum tricornutum CCAP 1055/1
8250275 Micromonas sp. RCC299
100474262 Ailuropoda melanoleuca
100522666 Sus scrofa
100549534 Meleagris gallopavo
100597285 Nomascus leucogenys
817756 Arabidopsis thaliana
179678 Caenorhabditis elegans
10111 Homo sapiens
19360 Mus musculus
64012 Rattus norvegicus
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