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Browse our TP53BP1 (TP53BP1) ELISA Kits

Full name:
Tumor Protein P53 Binding Protein 1 ELISA Kits (TP53BP1)
On www.antibodies-online.com are 10 Tumor Protein P53 Binding Protein 1 (TP53BP1) ELISA Kits from 7 different suppliers available. Additionally we are shipping TP53BP1 Antibodies (233) and TP53BP1 Proteins (3) and many more products for this protein. A total of 248 TP53BP1 products are currently listed.
Synonyms:
53BP1, m53BP1, MGC160112, p202, Tp53bp1, Trp53bp1
list all ELISA KIts Gene Name GeneID UniProt
TP53BP1 27223 P70399
TP53BP1 7158 Q12888
TP53BP1 296099  

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TP53BP1 (TP53BP1) ELISA Kits by Reactivity

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Top referenced TP53BP1 ELISA Kits

  1. Human TP53BP1 ELISA Kit for Sandwich ELISA - ABIN825076 : Jacot, Thezenas, Senal, Viglianti, Laberenne, Lopez-Crapez, Bibeau, Bleuse, Romieu, Lamy: BRCA1 promoter hypermethylation, 53BP1 protein expression and PARP-1 activity as biomarkers of DNA repair deficit in breast cancer. in BMC cancer 2014 (PubMed)

More ELISA Kits for TP53BP1 Interaction Partners

Mouse (Murine) Tumor Protein P53 Binding Protein 1 (TP53BP1) interaction partners

  1. Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 (show RAD51 ELISA Kits) and 53BP1 were recruited to these sites. H2AX (show H2AFX ELISA Kits) was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX (show H2AFX ELISA Kits) foci formation and DSB repair, whereas H2AX (show H2AFX ELISA Kits) was barely stabilized in response to secondary DSBs, in which gammaH2AX (show H2AFX ELISA Kits) foci were small and DSBs were not efficiently repaired

  2. Study showed that mammalian cells use microtubules in the cytoplasm to promote the mobility of sites of DNA damage in the nucleus; molecular details of this process remain to be determined, the main players, including the MOB (show SGMS1 ELISA Kits) domain of 53BP1, the linker of the nucleoskeleton, and cytoskeleton complex, kinesins, and microtubules are now known, allowing further study.

  3. These experiments define a novel requirement for 53BP1 in the fusions of DNA-PKcs (show PRKDC ELISA Kits)-deficient telomeres throughout the cell cycle.

  4. Study concludes that only the 53BP1 status in DNA lesions, induced by UVA or gamma-rays, is affected by A-type lamin (show LMNA ELISA Kits) deficiency, which was not observed for heterochromatin-related proteins HP1beta (show CBX1 ELISA Kits) and BMI1 (show BMI1 ELISA Kits).

  5. Binding of 53BP1 to methyl K810 occurs on E2 promoter binding factor (show E2F1 ELISA Kits) target genes and allows pRb (show PGR ELISA Kits) activity to be effectively integrated with the DNA damage response.

  6. study uncovers novel ATM (show ATM ELISA Kits)-independent functions for 53BP1 in the suppression of oncogenic translocations and in radioprotection

  7. Study concludes that 53BP1 promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 (show RIF1 ELISA Kits) and PTIP (show PAXIP1 ELISA Kits).

  8. Thus, RIF1 and 53BP1 cooperate to block DSB resection to promote NHEJ in G1, which is antagonized by BRCA1 in S phase to ensure a switch of DSB repair mode to homologous recombination

  9. loss of 53BP1 alters the translocatome by increasing rearrangements to intergenic regions.

  10. A mutant lacking the oligomerization domain (53BP1(oligo)) was only modestly impaired in promoting NHEJ of dysfunctional telomeres and showed no defect with regard to the repression of CtIP (show RBBP8 ELISA Kits).

Human Tumor Protein P53 Binding Protein 1 (TP53BP1) interaction partners

  1. interplay between 53BP1/NHEJ and BRCA1/HR is of great relevance for tumor treatment, as the 53BP1 status would be highly important for the treatment response of BRCA1-associated tumors.

  2. Exhaustion of 53BP1 by increasing the load of double strand breaks suppresses RAD51 (show RAD51 ELISA Kits) accumulation in repair foci during S and G2.

  3. TIRR is a novel 53BP1-interacting protein that participates in the DNA damage response

  4. These data suggest that multiple pathways collectively fine-tune the cellular levels of 53BP1 protein to ensure proper DSB repair and cell survival.

  5. USP28 (show USP28 ELISA Kits)-53BP1-p53 (show TP53 ELISA Kits)-p21 (show CDKN1A ELISA Kits) signaling pathway is also required to arrest cell growth after a prolonged prometaphase.

  6. analysis of centrinone resistance identified a 53BP1-USP28 (show USP28 ELISA Kits) module as critical for communicating mitotic challenges to the p53 (show TP53 ELISA Kits) circuit and TRIM37 (show TRIM37 ELISA Kits) as an enforcer of the singularity of centrosome assembly.

  7. his shows that 53BP1 protects both close and distant DSEs from degradation and that the association of unprotection with distance between DSEs favors ECS capture. Reciprocally, silencing CtIP (show RBBP8 ELISA Kits) lessens ECS capture both in control and 53BP1-depleted cells. We propose that close ends are immediately/rapidly tethered and ligated, whereas distant ends first require synapsis of the distant DSEs prior to ligation

  8. Increased 53BP1 expression (i.e., "unstable" expression) in nuclear foci of oncocytic follicular adenoma (FA) of the thyroid correlates with a higher incidence of DNA copy numbers compared with conventional FA.

  9. High 53BP1 mRNA is associated with head and neck cancer.

  10. hese findings confirmed that 53BP1 loss might be a negative factor for chemotherapy efficacy, promoting cell proliferation and inhibiting apoptosis by suppressing ATM (show ATM ELISA Kits)-CHK2 (show CHEK2 ELISA Kits)-P53 (show TP53 ELISA Kits) signaling, and finally inducing 5-FU resistance.

TP53BP1 Antigen Profile

Antigen Summary

May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Binds to sites of DNA damage. Plays a role in the response to DNA damage (By similarity).

Alternative names and synonyms associated with TP53BP1

  • tumor protein p53 binding protein 1 (TP53BP1) Elisa Kit
  • tumor protein p53 binding protein 1 (tp53bp1) Elisa Kit
  • tumor protein p53 binding protein 1 (predicted), 5 prime (TP53BP1) Elisa Kit
  • transformation related protein 53 binding protein 1 (Trp53bp1) Elisa Kit
  • tumor protein p53 binding protein 1 (Tp53bp1) Elisa Kit
  • 53BP1 Elisa Kit
  • m53BP1 Elisa Kit
  • MGC160112 Elisa Kit
  • p202 Elisa Kit
  • Tp53bp1 Elisa Kit
  • Trp53bp1 Elisa Kit

Protein level used designations for TP53BP1

tumor protein p53 binding protein 1 , tumor protein p53 binding protein, 1 , tumor suppressor p53-binding protein 1-like , tumor protein p53 binding protein 1 (predicted), 5 prime , tumor protein p53 binding protein 1 (predicted), 3 prime , murine p53-binding protein , p53-binding protein 1 , p53BP1 , transformation related protein 53 binding-protein 1 , tumor suppressor p53-binding protein 1 , tumor protein 53-binding protein, 1 , tumor protein p53-binding protein, 1 , transformation related protein 53 binding protein 1

GENE ID SPECIES
415589 Gallus gallus
467668 Pan troglodytes
478274 Canis lupus familiaris
509111 Bos taurus
100137429 Papio anubis
100468474 Ailuropoda melanoleuca
100490124 Xenopus (Silurana) tropicalis
100550605 Meleagris gallopavo
100607698 Nomascus leucogenys
100328680 Oryctolagus cuniculus
27223 Mus musculus
7158 Homo sapiens
296099 Rattus norvegicus
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