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Browse our TP53BP1 Proteins (TP53BP1)

Full name:
Tumor Protein P53 Binding Protein 1 Proteins (TP53BP1)
On are 2 Tumor Protein P53 Binding Protein 1 (TP53BP1) Proteins from 2 different suppliers available. Additionally we are shipping TP53BP1 Antibodies (233) and TP53BP1 Kits (10) and many more products for this protein. A total of 247 TP53BP1 products are currently listed.
53BP1, m53BP1, MGC160112, p202, Tp53bp1, Trp53bp1
list all proteins Gene Name GeneID UniProt
Mouse TP53BP1 TP53BP1 27223 P70399
TP53BP1 7158 Q12888
Rat TP53BP1 TP53BP1 296099  

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TP53BP1 Proteins (TP53BP1) by Origin

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Mouse (Murine) Tumor Protein P53 Binding Protein 1 (TP53BP1) interaction partners

  1. Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 (show RAD51 Proteins) and 53BP1 were recruited to these sites. H2AX (show H2AFX Proteins) was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX (show H2AFX Proteins) foci formation and DSB repair, whereas H2AX (show H2AFX Proteins) was barely stabilized in response to secondary DSBs, in which gammaH2AX (show H2AFX Proteins) foci were small and DSBs were not efficiently repaired

  2. Study showed that mammalian cells use microtubules in the cytoplasm to promote the mobility of sites of DNA damage in the nucleus; molecular details of this process remain to be determined, the main players, including the MOB (show SGMS1 Proteins) domain of 53BP1, the linker of the nucleoskeleton, and cytoskeleton complex, kinesins, and microtubules are now known, allowing further study.

  3. These experiments define a novel requirement for 53BP1 in the fusions of DNA-PKcs (show PRKDC Proteins)-deficient telomeres throughout the cell cycle.

  4. Study concludes that only the 53BP1 status in DNA lesions, induced by UVA or gamma-rays, is affected by A-type lamin (show LMNA Proteins) deficiency, which was not observed for heterochromatin-related proteins HP1beta (show CBX1 Proteins) and BMI1 (show BMI1 Proteins).

  5. Binding of 53BP1 to methyl K810 occurs on E2 promoter binding factor (show E2F1 Proteins) target genes and allows pRb (show PGR Proteins) activity to be effectively integrated with the DNA damage response.

  6. study uncovers novel ATM (show ATM Proteins)-independent functions for 53BP1 in the suppression of oncogenic translocations and in radioprotection

  7. Study concludes that 53BP1 promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 and PTIP (show PAXIP1 Proteins).

  8. Thus, RIF1 and 53BP1 cooperate to block DSB resection to promote NHEJ in G1, which is antagonized by BRCA1 in S phase to ensure a switch of DSB repair mode to homologous recombination

  9. loss of 53BP1 alters the translocatome by increasing rearrangements to intergenic regions.

  10. A mutant lacking the oligomerization domain (53BP1(oligo)) was only modestly impaired in promoting NHEJ of dysfunctional telomeres and showed no defect with regard to the repression of CtIP (show RBBP8 Proteins).

Human Tumor Protein P53 Binding Protein 1 (TP53BP1) interaction partners

  1. Increased 53BP1 expression (i.e., "unstable" expression) in nuclear foci of oncocytic follicular adenoma (FA) of the thyroid correlates with a higher incidence of DNA copy numbers compared with conventional FA.

  2. High 53BP1 mRNA is associated with head and neck cancer.

  3. hese findings confirmed that 53BP1 loss might be a negative factor for chemotherapy efficacy, promoting cell proliferation and inhibiting apoptosis by suppressing ATM (show ATM Proteins)-CHK2 (show CHEK2 Proteins)-P53 (show TP53 Proteins) signaling, and finally inducing 5-FU resistance.

  4. During live-cell imaging, 53BP1-GFP focus formation was observed within 10 minutes after UVC irradiation. Most 53BP1 foci resolved by 100 minutes. To block UVC-induced double-strand break repair in cancer cells, poly(ADP-ribose) polymerase (PARP (show PARP1 Proteins)) was targeted with ABT-888 (veliparib). PARP inhibition markedly enhanced UVC-irradiation-induced persistence of 53BP1-foci

  5. Combined effect of dynamic recruitment of RNF4 to KAP1 regulates the relative occupancy of 53BP1 and BRCA1 at double-strand break sites to direct DNA repair in a cell cycle-dependent manner.

  6. the formation of 53BP1, gammaH2AX (show H2AFX Proteins) foci and their co-localization induced by gamma-rays (2, 5, 10, 50, 200 cGy) in human lymphocytes, was analyzed.

  7. 5-Hydroxymethylcytosine (5hmC) accumulates at DNA damage foci and colocalizes with major DNA damage response proteins 53BP1 and gH2AX, revealing 5hmC as an epigenetic marker of DNA damage.

  8. we show that XIST and 53BP1 can be used to identify BRCA1-like breast cancer patients that have higher event rates and poor outcome after HD chemotherapy.

  9. kinetics of the accumulation of selected DNA repair-related proteins is protein specific at locally induced DNA lesions, and that the formation of gH2AX- and NBS1 (show NBN Proteins)-positive foci, but not 53BP1-positive NBs (show NBN Proteins), is cell cycle dependent in HeLa cells

  10. the interaction of 53BP1 with gammaH2AX (show H2AFX Proteins) is required for sustaining the 53BP1-dependent focal concentration of activated ATM (show ATM Proteins) that facilitates repair of DNA double-strand breaks in heterochromatin in G1.

TP53BP1 Protein Profile

Protein Summary

May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Binds to sites of DNA damage. Plays a role in the response to DNA damage (By similarity).

Alternative names and synonyms associated with TP53BP1

  • tumor protein p53 binding protein 1 (TP53BP1)
  • tumor protein p53 binding protein 1 (tp53bp1)
  • tumor protein p53 binding protein 1 (predicted), 5 prime (TP53BP1)
  • transformation related protein 53 binding protein 1 (Trp53bp1)
  • tumor protein p53 binding protein 1 (Tp53bp1)
  • 53BP1 protein
  • m53BP1 protein
  • MGC160112 protein
  • p202 protein
  • Tp53bp1 protein
  • Trp53bp1 protein

Protein level used designations for TP53BP1

tumor protein p53 binding protein 1 , tumor protein p53 binding protein, 1 , tumor suppressor p53-binding protein 1-like , tumor protein p53 binding protein 1 (predicted), 5 prime , tumor protein p53 binding protein 1 (predicted), 3 prime , murine p53-binding protein , p53-binding protein 1 , p53BP1 , transformation related protein 53 binding-protein 1 , tumor suppressor p53-binding protein 1 , tumor protein 53-binding protein, 1 , tumor protein p53-binding protein, 1 , transformation related protein 53 binding protein 1

415589 Gallus gallus
467668 Pan troglodytes
478274 Canis lupus familiaris
509111 Bos taurus
100137429 Papio anubis
100468474 Ailuropoda melanoleuca
100490124 Xenopus (Silurana) tropicalis
100550605 Meleagris gallopavo
100607698 Nomascus leucogenys
100328680 Oryctolagus cuniculus
27223 Mus musculus
7158 Homo sapiens
296099 Rattus norvegicus
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