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Browse our TP53BP1 Proteins (TP53BP1)

Full name:
Tumor Protein P53 Binding Protein 1 Proteins (TP53BP1)
On www.antibodies-online.com are 3 Tumor Protein P53 Binding Protein 1 (TP53BP1) Proteins from 3 different suppliers available. Additionally we are shipping TP53BP1 Antibodies (233) and TP53BP1 Kits (10) and many more products for this protein. A total of 248 TP53BP1 products are currently listed.
Synonyms:
53BP1, m53BP1, MGC160112, p202, Tp53bp1, Trp53bp1
list all proteins Gene Name GeneID UniProt
Mouse TP53BP1 TP53BP1 27223 P70399
TP53BP1 7158 Q12888
Rat TP53BP1 TP53BP1 296099  

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TP53BP1 Proteins (TP53BP1) by Origin

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Mouse (Murine) Tumor Protein P53 Binding Protein 1 (TP53BP1) interaction partners

  1. Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 (show RAD51 Proteins) and 53BP1 were recruited to these sites. H2AX (show H2AFX Proteins) was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX (show H2AFX Proteins) foci formation and DSB repair, whereas H2AX (show H2AFX Proteins) was barely stabilized in response to secondary DSBs, in which gammaH2AX (show H2AFX Proteins) foci were small and DSBs were not efficiently repaired

  2. Study showed that mammalian cells use microtubules in the cytoplasm to promote the mobility of sites of DNA damage in the nucleus; molecular details of this process remain to be determined, the main players, including the MOB (show SGMS1 Proteins) domain of 53BP1, the linker of the nucleoskeleton, and cytoskeleton complex, kinesins, and microtubules are now known, allowing further study.

  3. These experiments define a novel requirement for 53BP1 in the fusions of DNA-PKcs (show PRKDC Proteins)-deficient telomeres throughout the cell cycle.

  4. Study concludes that only the 53BP1 status in DNA lesions, induced by UVA or gamma-rays, is affected by A-type lamin (show LMNA Proteins) deficiency, which was not observed for heterochromatin-related proteins HP1beta (show CBX1 Proteins) and BMI1 (show BMI1 Proteins).

  5. Binding of 53BP1 to methyl K810 occurs on E2 promoter binding factor (show E2F1 Proteins) target genes and allows pRb (show PGR Proteins) activity to be effectively integrated with the DNA damage response.

  6. study uncovers novel ATM (show ATM Proteins)-independent functions for 53BP1 in the suppression of oncogenic translocations and in radioprotection

  7. Study concludes that 53BP1 promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 and PTIP (show PAXIP1 Proteins).

  8. Thus, RIF1 and 53BP1 cooperate to block DSB resection to promote NHEJ in G1, which is antagonized by BRCA1 in S phase to ensure a switch of DSB repair mode to homologous recombination

  9. loss of 53BP1 alters the translocatome by increasing rearrangements to intergenic regions.

  10. A mutant lacking the oligomerization domain (53BP1(oligo)) was only modestly impaired in promoting NHEJ of dysfunctional telomeres and showed no defect with regard to the repression of CtIP (show RBBP8 Proteins).

Human Tumor Protein P53 Binding Protein 1 (TP53BP1) interaction partners

  1. interplay between 53BP1/NHEJ and BRCA1/HR is of great relevance for tumor treatment, as the 53BP1 status would be highly important for the treatment response of BRCA1-associated tumors.

  2. Exhaustion of 53BP1 by increasing the load of double strand breaks suppresses RAD51 (show RAD51 Proteins) accumulation in repair foci during S and G2.

  3. TIRR is a novel 53BP1-interacting protein that participates in the DNA damage response

  4. These data suggest that multiple pathways collectively fine-tune the cellular levels of 53BP1 protein to ensure proper DSB repair and cell survival.

  5. USP28 (show USP28 Proteins)-53BP1-p53 (show TP53 Proteins)-p21 (show CDKN1A Proteins) signaling pathway is also required to arrest cell growth after a prolonged prometaphase.

  6. analysis of centrinone resistance identified a 53BP1-USP28 (show USP28 Proteins) module as critical for communicating mitotic challenges to the p53 (show TP53 Proteins) circuit and TRIM37 (show TRIM37 Proteins) as an enforcer of the singularity of centrosome assembly.

  7. his shows that 53BP1 protects both close and distant DSEs from degradation and that the association of unprotection with distance between DSEs favors ECS capture. Reciprocally, silencing CtIP (show RBBP8 Proteins) lessens ECS capture both in control and 53BP1-depleted cells. We propose that close ends are immediately/rapidly tethered and ligated, whereas distant ends first require synapsis of the distant DSEs prior to ligation

  8. Increased 53BP1 expression (i.e., "unstable" expression) in nuclear foci of oncocytic follicular adenoma (FA) of the thyroid correlates with a higher incidence of DNA copy numbers compared with conventional FA.

  9. High 53BP1 mRNA is associated with head and neck cancer.

  10. hese findings confirmed that 53BP1 loss might be a negative factor for chemotherapy efficacy, promoting cell proliferation and inhibiting apoptosis by suppressing ATM (show ATM Proteins)-CHK2 (show CHEK2 Proteins)-P53 (show TP53 Proteins) signaling, and finally inducing 5-FU resistance.

TP53BP1 Protein Profile

Protein Summary

May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation. Binds to sites of DNA damage. Plays a role in the response to DNA damage (By similarity).

Alternative names and synonyms associated with TP53BP1

  • tumor protein p53 binding protein 1 (TP53BP1)
  • tumor protein p53 binding protein 1 (tp53bp1)
  • tumor protein p53 binding protein 1 (predicted), 5 prime (TP53BP1)
  • transformation related protein 53 binding protein 1 (Trp53bp1)
  • tumor protein p53 binding protein 1 (Tp53bp1)
  • 53BP1 protein
  • m53BP1 protein
  • MGC160112 protein
  • p202 protein
  • Tp53bp1 protein
  • Trp53bp1 protein

Protein level used designations for TP53BP1

tumor protein p53 binding protein 1 , tumor protein p53 binding protein, 1 , tumor suppressor p53-binding protein 1-like , tumor protein p53 binding protein 1 (predicted), 5 prime , tumor protein p53 binding protein 1 (predicted), 3 prime , murine p53-binding protein , p53-binding protein 1 , p53BP1 , transformation related protein 53 binding-protein 1 , tumor suppressor p53-binding protein 1 , tumor protein 53-binding protein, 1 , tumor protein p53-binding protein, 1 , transformation related protein 53 binding protein 1

GENE ID SPECIES
415589 Gallus gallus
467668 Pan troglodytes
478274 Canis lupus familiaris
509111 Bos taurus
100137429 Papio anubis
100468474 Ailuropoda melanoleuca
100490124 Xenopus (Silurana) tropicalis
100550605 Meleagris gallopavo
100607698 Nomascus leucogenys
100328680 Oryctolagus cuniculus
27223 Mus musculus
7158 Homo sapiens
296099 Rattus norvegicus
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