Browse our UNG Proteins (UNG)

Full name:
Uracil-DNA Glycosylase Proteins (UNG)
On are 175 Uracil-DNA Glycosylase (UNG) Proteins from 9 different suppliers available. Additionally we are shipping UNG Antibodies (137) and UNG Kits (4) and many more products for this protein. A total of 331 UNG products are currently listed.
An02g14790, AO090001000732, BA5648, DDBDRAFT_0204444, DDBDRAFT_0214910, DDB_0204444, DDB_0214910, DGU, ECK2578, HIGM4, HIGM5, JW2564, PSPTO4236, UDG, ung, UNG1, UNG2, UNG15, zgc:56102
list all proteins Gene Name GeneID UniProt
Mouse UNG UNG 22256 P97931
Human UNG UNG 7374 P13051
Rat UNG UNG 304577  

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UNG Proteins (UNG) by Origin

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More Proteins for UNG Interaction Partners

Vaccinia Virus (VACV) Uracil-DNA Glycosylase (UNG) interaction partners

  1. The crystal structure of D4 in complex with DNA is presented. D4 is a uracil-DNA glycosylase.

  2. description of crystal structure of uracil-DNA glycosylase; several distinctive features revealed

  3. Both uracil DNA glycosylase and deoxyuridine triphosphatase (show DUT Proteins) activities are required for full virulence in mice.

Mouse (Murine) Uracil-DNA Glycosylase (UNG) interaction partners

  1. Pms2 (show PMS2 Proteins)/Mlh1 (show MLH1 Proteins) and multiple uracil glycosylases act jointly, each one with a distinct strand bias, to enlarge the immunoglobulin gene mutation spectrum from G-C to A-T bases.

  2. UNG deficiency reduces B cell clonal expansion in the germinal center in mice and blocks the proliferation of tumor B cells expressing AID.

  3. UNG might be involved in Tet-mediated DNA demethylation.

  4. Study showed elevated levels of homocysteine via dietary folic acid deficiency and chronic hypoperfusion negatively affect learning in Ung deficient mice, while increasing GFAP (show GFAP Proteins) immunoreactivity within the dentate gyrus of the hippocampus

  5. Ung and Pms2 (show PMS2 Proteins) may exert a mutual backup function for the DNA incision that promotes synthesis by Poleta, each with a distinct strand bias.

  6. transcription factor E2A binds to the UNG2 promoter and represses UNG2 expression.

  7. Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase.

  8. Our results uncover a specific need for UNG in class-switch recombination for timely and efficient acute Ab responses in vivo

  9. Compared with WT mice, UNG deficiency caused elevated frequency of C:G mutations, suggesting that UNG-mediated U excision led to error-free as well as error-prone repair.

  10. we show that AID binds cooperatively with UNG and the mismatch repair proteins Msh2-Msh6 to Ig Smu and Sgamma3 regions

Human Uracil-DNA Glycosylase (UNG) interaction partners

  1. Results suggest that the UNG2 N-terminus may serve as a flexible scaffold to tether PCNA and RPA at the replication fork, and that post-translational modifications on the UNG2 N-terminus disrupt formation of the PCNA-UNG2-RPA protein complex.

  2. HIV-1 vpr reprograms CRL4(DCAF1) E3 to direct HLTF (show HLTF Proteins) for proteasome-dependent degradation independent from previously reported Vpr interactions with base excision repair enzyme uracil DNA glycosylase (UNG2) and crossover junction endonuclease MUS81 (show MUS81 Proteins), which Vpr also directs for degradation via CRL4(DCAF1) E3.

  3. Uracil DNA glycosylase (UNG) is the primary glycosylase responsible for the removal of uracils adjacent to cisplatin ICLs, whereas other uracil glycosylases can process uracils in the context of undamaged DNA.

  4. find that the energetic nature of the observed binding free energies of human 8-oxoguanine DNA glycosylase (hOGG1) and human uracil DNA glycosylase (hUNG) for undamaged DNA are derived from different sources. Although hOGG1 uses primarily nonelectrostatic binding interactions with nonspecific DNA, hUNG uses a salt-dependent electrostatic binding mode

  5. The authors show that Vpr can form a trimolecular complex with UNG2 (show CCNO Proteins) and RPA32 (show RPA2 Proteins) and the positive effect of UNG2 (show CCNO Proteins) and RPA32 (show RPA2 Proteins) on the reverse transcription process leading to optimal virus replication and dissemination between the primary target cells of HIV-1.

  6. Data suggest novel mechanism in innate immunity allows cytokine TGF-beta (show TGFB1 Proteins) to restrict viral circular DNA in hepatocyte nuclei via innate immunity; AID deaminates circular DNA of hepatitis B virus leading to DNA degradation; mechanism depends on UNG.

  7. UNG rs246079 G/A contributes to decreased risk of esophageal cancer in a Chinese population.

  8. base excision by UNG1/2 perturbs transcription of the affected gene

  9. UNG interaction with damaged DNA is dominated by the nonelectrostatic free energy term (DeltaGnon = -7.2 +/- 0.1 kcal mol (show DUOXA1 Proteins)(-1)), yet retains the nonspecific electrostatic contribution (DeltaGelect = -2.3 +/- 0.2 kcal mol (show DUOXA1 Proteins)(-1)).

  10. Data shows that cancer cells express UNG2 (show CCNO Proteins) gene at levels similar to or higher than those seen with peripheral B cells.

Zebrafish Uracil-DNA Glycosylase (UNG) interaction partners

  1. These results together suggest that Unga is implicated in postfertilization genomic DNA demethylation, zygotic gene transcription, and normal embryonic development in zebrafish.

UNG Protein Profile

Protein Summary

This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases.

Alternative names and synonyms associated with UNG

  • uracil-DNA glycosylase (ung)
  • uracil-DNA glycosylase (ung2)
  • uracil-DNA glycosylase (ung-2)
  • uracil-DNA-glycosylase (ung)
  • uracil-DNA glycosylase (ung-1)
  • uracil-DNA glycosylase (ANI_1_3358024)
  • uracil-DNA glycosylase (AOR_1_1318164)
  • uracil glycosylase (uglA)
  • uracil-DNA glycosylase (Arnit_2731)
  • temporal expression: early (D4R)
  • uracil DNA glycosylase (Ung)
  • uracil-DNA glycosylase (UNG)
  • uracil-DNA glycosylase (LOC100338366)
  • uracil-DNA glycosylase (Ung)
  • uracil-DNA glycosylase a (unga)
  • An02g14790 protein
  • AO090001000732 protein
  • BA5648 protein
  • DDBDRAFT_0204444 protein
  • DDBDRAFT_0214910 protein
  • DDB_0204444 protein
  • DDB_0214910 protein
  • DGU protein
  • ECK2578 protein
  • HIGM4 protein
  • HIGM5 protein
  • JW2564 protein
  • PSPTO4236 protein
  • UDG protein
  • ung protein
  • UNG1 protein
  • UNG2 protein
  • UNG15 protein
  • zgc:56102 protein

Protein level used designations for Uracil-DNA Glycosylase Proteins (UNG)

uracil-DNA glycosylase , UDG , uracil-DNA glycosylase nuclear isoform , uracil-DNA glycosylase 1, uracil-DNA glycosylase 2

2662329 Bordetella bronchiseptica RB50
8713586 Citrobacter rodentium ICC168
5820241 Bordetella petrii DSM 12804
2797409 Listeria monocytogenes serotype 4b str. F2365
1211645 Streptomyces avermitilis MA-4680
3230844 Campylobacter jejuni RM1221
1208883 Coxiella burnetii RSA 493
3104550 Methylococcus capsulatus str. Bath
1185916 Pseudomonas syringae pv. tomato str. DC3000
1085374 Bacillus anthracis str. Ames
1175534 Yersinia pestis CO92
1171313 Shewanella oneidensis MR-1
1249149 Salmonella enterica subsp. enterica serovar Typhi str. CT18
2860413 Staphylococcus aureus subsp. aureus MRSA252
4915761 Clostridium difficile 630
947067 Escherichia coli str. K-12 substr. MG1655
887410 Mycobacterium tuberculosis H37Rv
904411 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
2798412 Listeria monocytogenes serotype 4b str. F2365
3515458 Psychrobacter arcticus 273-4
4980018 Aspergillus niger CBS 513.88
5991194 Aspergillus oryzae RIB40
8621357 Dictyostelium discoideum AX4
9080704 Listeria seeligeri serovar 1/2b str. SLCC3954
9082692 Listeria seeligeri serovar 1/2b str. SLCC3954
9172927 Arcobacter nitrofigilis DSM 7299
3707565 Vaccinia virus
22256 Mus musculus
443838 Xenopus laevis
374010 Gallus gallus
452217 Pan troglodytes
7374 Homo sapiens
486315 Canis lupus familiaris
100338366 Oryctolagus cuniculus
304577 Rattus norvegicus
511381 Bos taurus
393949 Danio rerio
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