Browse our CDC6 Proteins (CDC6)

Full name:
Cell Division Cycle 6 Homolog (S. Cerevisiae) Proteins (CDC6)
On www.antibodies-online.com are 7 Cell Division Cycle 6 Homolog (S. Cerevisiae) (CDC6) Proteins from 4 different suppliers available. Additionally we are shipping CDC6 Antibodies (187) and CDC6 Kits (5) and many more products for this protein. A total of 221 CDC6 products are currently listed.
Synonyms:
CDC18L, HsCDC6, HsCDC18
list all proteins Gene Name GeneID UniProt
CDC6 990 Q99741
CDC6 23834 O89033
Rat CDC6 CDC6 360621  

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CDC6 Proteins (CDC6) by Origin

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More Proteins for CDC6 Interaction Partners

Human Cell Division Cycle 6 Homolog (S. Cerevisiae) (CDC6) interaction partners

  1. 6 overexpression may contribute to the high proliferation and low apoptosis in chronic myeloid leukemia (show BCL11A Proteins) cells and can be regulated by BCR/ABL (show ABL1 Proteins) signal transduction through downstream phosphoinositide 3-kinase/Akt (show AKT1 Proteins) and Janus kinase/signal transducer and activator of transcription (show STAT1 Proteins) pathways, suggesting cell division cycle protein 6 as a potential therapeutic target in chronic myeloid leukemia (show BCL11A Proteins).

  2. the level of Cdc6 phosphorylation at serine 54 (S54P) was increased in E7-expressing cells. S54P was associated with an increase in the total amount of Cdc6 and chromatin-bound Cdc6. DNA damage-enhanced upregulation and chromatin binding of Cdc6 appeared to be due to downregulation of cyclin-dependent kinase 1 (Cdk1 (show CDK1 Proteins)) as Cdk1 (show CDK1 Proteins) knockdown increased Cdc6 levels

  3. this study provides a novel regulatory signaling pathway of CDC6-regulated epithelial ovarian cancer growth

  4. The data demonstrate that Cdc6 serves as a regulator of ribosomal DNA transcription initiation, and indicate a mechanism by which initiation of ribosomal DNA transcription and DNA replication can be coordinated in cells.

  5. CDC6 and Cyclin F (show CCNF Proteins) interact through defined sequence motifs that promote CDC6 ubiquitylation and degradation.

  6. Cdc6 interacts with centrosomes during mitotic cell division.

  7. The current study suggests that miR26a, miR26b, and CDC6 and factors regulating their expression represent potential cancer diagnostic and prognostic markers as well as anticancer targets.

  8. The cell cycle-dependent centrosomal localization of Cdc6 in S and G2 phases suggest a novel function of Cdc6 in centrosomes.

  9. Cdk1 (show CDK1 Proteins) contributes to the nuclear export of Cdc6 at the S-to-G2 transition.

  10. Aberrant expression of both cyclin D1 (show CCND1 Proteins) and CDC6 by YB-1 (show YBX1 Proteins) over-expression may collaboratively participate in lung carcinogenesis.

Mouse (Murine) Cell Division Cycle 6 Homolog (S. Cerevisiae) (CDC6) interaction partners

  1. CDK1 (show CDK1 Proteins) activation proceeds with concomitant inhibition by CDC6, which tunes the timing of the M-phase entry during the embryonic cell cycle

  2. Cdc6 continued to block apoptosome assembly induced by a non-cytochrome c (show CYCS Proteins) or some other mechanism, suppressing seemingly unintended apoptosis when promoting cell proliferation

  3. show that MyoD can occupy an E-box within the promoter of Cdc6 and that this association, along with E2F3a, is required for its activity.

  4. CDC6 is essential for spindle formation in mouse oocytes

CDC6 Protein Profile

Protein Summary

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.

Alternative names and synonyms associated with CDC6

  • cell division cycle 6 homolog (S. cerevisiae) (CDC6)
  • cell division cycle 6 (CDC6)
  • cell division cycle 6 (Cdc6)
  • CDC18L protein
  • HsCDC6 protein
  • HsCDC18 protein

Protein level used designations for CDC6

CDC6 cell division cycle 6 homolog , CDC6-related protein , cdc18-related protein , cell division control protein 6 homolog , cell division cycle 6 homolog , p62(cdc6) , CDC18(S.pombe)

GENE ID SPECIES
100067788 Equus caballus
990 Homo sapiens
23834 Mus musculus
360621 Rattus norvegicus
515301 Bos taurus
480527 Canis lupus familiaris
100522031 Sus scrofa
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