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this study provides a novel regulatory signaling pathway of CDC6-regulated epithelial ovarian cancer growth
The data demonstrate that Cdc6 serves as a regulator of ribosomal DNA transcription initiation, and indicate a mechanism by which initiation of ribosomal DNA transcription and DNA replication can be coordinated in cells.
CDC6 and Cyclin F (show CCNF Proteins) interact through defined sequence motifs that promote CDC6 ubiquitylation and degradation.
Cdc6 interacts with centrosomes during mitotic cell division.
The current study suggests that miR26a, miR26b, and CDC6 and factors regulating their expression represent potential cancer diagnostic and prognostic markers as well as anticancer targets.
The cell cycle-dependent centrosomal localization of Cdc6 in S and G2 phases suggest a novel function of Cdc6 in centrosomes.
Cdk1 (show CDK1 Proteins) contributes to the nuclear export of Cdc6 at the S-to-G2 transition.
Aberrant expression of both cyclin D1 (show CCND1 Proteins) and CDC6 by YB-1 (show YBX1 Proteins) over-expression may collaboratively participate in lung carcinogenesis.
The Cdc6 is the AAA+ ATPase that assembles prereplicative complexes on replication origins in eukaryotic chromosomes and two more functions in mammalian cells to promote cell proliferation and survival.
These results provided new evidence for the regulatory mechanism of aberrant CDC6 oncogene (show RAB1A Proteins) transcription by FOXM1 (show FOXM1 Proteins) and AR, two highly expressed transcription factors in prostate cancer cells
CDK1 (show CDK1 Proteins) activation proceeds with concomitant inhibition by CDC6, which tunes the timing of the M-phase entry during the embryonic cell cycle
Cdc6 continued to block apoptosome assembly induced by a non-cytochrome c (show CYCS Proteins) or some other mechanism, suppressing seemingly unintended apoptosis when promoting cell proliferation
show that MyoD can occupy an E-box within the promoter of Cdc6 and that this association, along with E2F3a, is required for its activity.
CDC6 is essential for spindle formation in mouse oocytes
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
CDC6 cell division cycle 6 homolog
, CDC6-related protein
, cdc18-related protein
, cell division control protein 6 homolog
, cell division cycle 6 homolog