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AZD7762 demonstrates synergy with regard to inhibition of AR-CDC6-ATR (show ANTXR1 Proteins)-Chk1 (show CHEK1 Proteins) signaling.
The opposing effects of ORC1 (show ORC1L Proteins) (represor) and CDC6 (gene activator) in controlling the level of Cyclin E (show CCNE1 Proteins) ensures genome stability and a mechanism for linking directly DNA replication and cell division commitment.
Data suggest that regulation of microtubule nucleation and recruitment of pericentriolar proteins to centrosome requires Cdc6 ATPase activity, as well as centrosomal localization of Cdc6.
6 overexpression may contribute to the high proliferation and low apoptosis in chronic myeloid leukemia (show BCL11A Proteins) cells and can be regulated by BCR/ABL (show ABL1 Proteins) signal transduction through downstream phosphoinositide 3-kinase/Akt (show AKT1 Proteins) and Janus kinase/signal transducer and activator of transcription (show STAT1 Proteins) pathways, suggesting cell division cycle protein 6 as a potential therapeutic target in chronic myeloid leukemia (show BCL11A Proteins).
the level of Cdc6 phosphorylation at serine 54 (S54P) was increased in E7-expressing cells. S54P was associated with an increase in the total amount of Cdc6 and chromatin-bound Cdc6. DNA damage-enhanced upregulation and chromatin binding of Cdc6 appeared to be due to downregulation of cyclin-dependent kinase 1 (Cdk1 (show CDK1 Proteins)) as Cdk1 (show CDK1 Proteins) knockdown increased Cdc6 levels
this study provides a novel regulatory signaling pathway of CDC6-regulated epithelial ovarian cancer growth
The data demonstrate that Cdc6 serves as a regulator of ribosomal DNA transcription initiation, and indicate a mechanism by which initiation of ribosomal DNA transcription and DNA replication can be coordinated in cells.
CDC6 and Cyclin F (show CCNF Proteins) interact through defined sequence motifs that promote CDC6 ubiquitylation and degradation.
Cdc6 interacts with centrosomes during mitotic cell division.
The current study suggests that miR26a, miR26b, and CDC6 and factors regulating their expression represent potential cancer diagnostic and prognostic markers as well as anticancer targets.
CDK1 (show CDK1 Proteins) activation proceeds with concomitant inhibition by CDC6, which tunes the timing of the M-phase entry during the embryonic cell cycle
Cdc6 continued to block apoptosome assembly induced by a non-cytochrome c (show CYCS Proteins) or some other mechanism, suppressing seemingly unintended apoptosis when promoting cell proliferation
show that MyoD can occupy an E-box within the promoter of Cdc6 and that this association, along with E2F3a, is required for its activity.
CDC6 is essential for spindle formation in mouse oocytes
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
CDC6 cell division cycle 6 homolog
, CDC6-related protein
, cdc18-related protein
, cell division control protein 6 homolog
, cell division cycle 6 homolog