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En1 is important for ventral nuclei of the lateral lemniscus neuron development and survival.
in absence of En1 and Pitx3 (show PITX3 Proteins), only a limited number of Mesodiencephalic dopaminergic neurons are present in mouse embryo.
Engrailed plays an evolutionarily conserved role in the separate innervation of vertebrate epaxial-hypaxial muscle.
FGFR (show FGFR2 Proteins) Inhibitor Ameliorates Hypophosphatemia and Impaired Engrailed-1/Wnt (show WNT2 Proteins) Signaling in FGF2 (show FGF2 Proteins) High Molecular Weight Isoform
En1 and Dbx1 (show DBX1 Proteins) microdomains distinguish midbrain dopamine and hypothalamic neurons
En1-null cells also fail to express the transcription factor FoxP1 (show FOXP1 Proteins), suggesting that FoxP1 (show FOXP1 Proteins) lies downstream of En1.
The homeoprotein Engrailed is not only a survival factor for mesencephalic dopaminergic (mDA) neurons during development, but continues to exert neuroprotective and physiological functions in adult mDA neurons. [Review]
En1+/Otx2 (show OTX2 Proteins) Mutants Exhibit Increased Intra-Individual Fluctuation in Activity, Habituation, Risk-Taking Behavior, Sociability, and Hedonic-Like Behavior.
En1 is involved in two distinct molecular mechanisms that regulate the establishment of neuronal connectivity to limb-musculature.
low-frequency non-coding variant near a novel locus, EN1, with an effect on bone mineral density--which was also associated with a decreased risk of fracture
EN1 is an activator of intrinsic inflammatory pathways associated with prosurvival in basal-like breast cancer.
The current review describes the role of two such factors, Nurr1 and engrailed, in differentiation, maturation, and in normal physiological functions including acquisition of neurotransmitter identity.
EN1 is a biologic predictor of poor prognosis in patients with salivary adenoid cystic carcinoma.
Homeobox protein engrailed-1 protein regulates transcription of the utrophin gene.
EN1 might be a negative regulatory factor for UTROPHIN.
The result of this study found a strong association between the EN1 rs1438852 polymorphism and Parkinson's disease.
En-1 exerts its repressive effect by a mechanism negatively controlling the level of beta-catenin (show CTNNB1 Proteins).
When beta-catenin (show CTNNB1 Proteins) is activated in transgenic En1 expressing cells, it induces Dermo1 (show TWIST2 Proteins) expression in all cells of the En1 domain and disrupts muscle gene expression.
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.
, engrailed homolog 1
, homeobox protein en-1
, homeobox protein engrailed-1
, homeobox protein en-1a
, homeobox protein engrailed-1a
, engrailed 1