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En1-null cells also fail to express the transcription factor FoxP1 (show FOXP1 Proteins), suggesting that FoxP1 (show FOXP1 Proteins) lies downstream of En1.
The homeoprotein Engrailed is not only a survival factor for mesencephalic dopaminergic (mDA) neurons during development, but continues to exert neuroprotective and physiological functions in adult mDA neurons. [Review]
En1+/Otx2 (show OTX2 Proteins) Mutants Exhibit Increased Intra-Individual Fluctuation in Activity, Habituation, Risk-Taking Behavior, Sociability, and Hedonic-Like Behavior.
En1 is involved in two distinct molecular mechanisms that regulate the establishment of neuronal connectivity to limb-musculature.
low-frequency non-coding variant near a novel locus, EN1, with an effect on bone mineral density--which was also associated with a decreased risk of fracture
The findings of this study support a progressive retrograde degeneration of En1(+/-) nigrostriatal neurons, akin to what is suggested to occur in Parkinson disease.
This study identified En1 as a gene essential for MNTB neuron development and Sound localization.
Two crucial mediators of mesodiencephalic dopaminergic neuronal development, En1 and Pitx3 (show PITX3 Proteins), interact in dopaminergic subset specification.
Analysis of an allelic series of conditional mutants showed that En1 is the predominant functional En paralog in maturing 5-HT (show DDC Proteins) neurons
En1 and En2 (show EN2 Proteins) act together in multiple cerebellar cell types to determine overall growth and formation of particular fissures.
EN1 is an activator of intrinsic inflammatory pathways associated with prosurvival in basal-like breast cancer.
The current review describes the role of two such factors, Nurr1 and engrailed, in differentiation, maturation, and in normal physiological functions including acquisition of neurotransmitter identity.
EN1 is a biologic predictor of poor prognosis in patients with salivary adenoid cystic carcinoma.
Homeobox protein engrailed-1 protein regulates transcription of the utrophin gene.
EN1 might be a negative regulatory factor for UTROPHIN.
The result of this study found a strong association between the EN1 rs1438852 polymorphism and Parkinson's disease.
En-1 exerts its repressive effect by a mechanism negatively controlling the level of beta-catenin (show CTNNB1 Proteins).
When beta-catenin (show CTNNB1 Proteins) is activated in transgenic En1 expressing cells, it induces Dermo1 (show TWIST2 Proteins) expression in all cells of the En1 domain and disrupts muscle gene expression.
Epigenetic suppression along 2q14.2 is common to most colorectal cancers and the presence of a methylated EN1 CpG island in stool DNA might be used as biomarker of neoplastic disease.
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system.
, engrailed homolog 1
, homeobox protein en-1
, homeobox protein engrailed-1
, homeobox protein en-1a
, homeobox protein engrailed-1a
, engrailed 1