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These results suggest that DAT (show SLC6A3 Antibodies) expression affects TH expression and phosphorylation largely in DA terminal field compartments.
These behavioral and molecular phenotypes indicate that a genetic-driven DAT (show SLC6A3 Antibodies) hypofunction alters neurodevelopmental trajectories consistent with ADHD, but not with schizophrenia and bipolar disorders.
An exquisite microanatomical regulation of dopamine by the dopamine transporter was identified in striosomes relative to the matrix in the corpus striatum.
Data suggest that environment pollutants methylmercury and 1-methyl-4-phenylpyridinium decrease release of dopamine from dopaminergic neurons; this mechanism involves down-regulation of expression of Slc6a3 (show SLC6A3 Antibodies).
This study show that Dopamine transporter is enriched in filopodia and induces filopodia formation.
The sigma-1R deficiency through suppressing NR2B (show GRIN2B Antibodies) function and DAT (show SLC6A3 Antibodies) expression can reduce MPTP (show PTPN2 Antibodies)-induced death of dopaminergic neurons and parkinsonism.
DAT (show SLC6A3 Antibodies) gene knockout in mice results dendritic spine loss in pyramidal neurons in the CA1 (show CA1 Antibodies) field of the hippocampus.
Results show that moderate increases in DAT (show SLC6A3 Antibodies) function cause spontaneous dopaminergic cell loss, oxidative stress and fine motor impairment that is reversed by l-DOPA treatment
Chronic and acute reductions of DAT (show SLC6A3 Antibodies) functioning in mice impaired decision-making.
These results demonstrate that the presence of the N-terminal tag leads to impaired DAT (show SLC6A3 Antibodies) protein expression in vivo due in part to improper trafficking of the tagged transporter.
SLC6A3 (show SLC6A3 Antibodies) gene variants have been reported to be implicated in alcohol addiction, nicotine dependence and other addictive behaviors.
The 3' VNTR polymorphism affects human DAT (show SLC6A3 Antibodies) expression level in iPSC-derived human dopaminergic neurons.
Study measured smooth pursuit in 110 healthy subjects genotyped for two well-documented polymorphisms, the COMT (show COMT Antibodies) Val(158)Met polymorphism and the SLC6A3 (show SLC6A3 Antibodies) 3'-UTR (show UTS2R Antibodies)-VNTR polymorphism; modulation of striatal dopamine activity by the SLC6A3 (show SLC6A3 Antibodies) 3'-UTR (show UTS2R Antibodies)-VNTR polymorphism had no significant functional effect.
Allosteric modulation of human dopamine transporter activity under conditions promoting its dimerization
A combined haplotype (9R-A2) of DAT-1 (show SLC6A3 Antibodies) and DRD2 (show DRD2 Antibodies) genes was associated with the murderer phenotype among Pakistani violent criminal inmates.
SLC6A3 gene may have a role in susceptibility to late-onset alcohol dependence in the Han Chinese population.
This result suggests that persistent drug-induced parkinsonism in patients with visually normal DAT (show SLC6A3 Antibodies) imaging may be associated with subtle decrement of DAT (show SLC6A3 Antibodies) activity.
the dopamine transporter SLC6A3 constitutes a novel biomarker that is highly specific for clear cell renal cell carcinoma
Data suggest that variants rs28363170 and rs3836790 in the solute carrier family 6 member 3 gene are not associated with sporadic Parkinson's disease in Han Chinese population.
Study systematically designed and characterized a set of 24 substrate-based bivalent ligands, and in combination with mutagenesis, induced-fit docking calculations, electrophysiology, and cysteine accessibility measurements; revealed novel insight into the molecular basis of substrate recognition in hSERT (show SLC6A4 Antibodies) and hDAT
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.
LIM domain only protein 3
, LIM domain only 3
, neuronal-specific transcription factor DAT1
, dopamine-inducible LIM-domain transcription factor DAT1
, DA transporter
, dopamine transporter 1
, sodium-dependent dopamine transporter
, solute carrier family 6 member 3
, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
, solute carrier family 6, member 3