Browse our ADAM12 Proteins (ADAM12)

Full name:
ADAM Metallopeptidase Domain 12 Proteins (ADAM12)
On are 17 ADAM Metallopeptidase Domain 12 (ADAM12) Proteins from 8 different suppliers available. Additionally we are shipping ADAM12 Antibodies (90) and ADAM12 Kits (33) and many more products for this protein. A total of 151 ADAM12 products are currently listed.
adam12, MCMP, MCMPMltna, mKIAA4001, MLTN, MLTNA
list all proteins Gene Name GeneID UniProt
ADAM12 11489 Q61824
ADAM12 8038 O43184
Rat ADAM12 ADAM12 679837  

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ADAM12 Proteins (ADAM12) by Origin

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Top referenced ADAM12 Proteins

  1. Human ADAM12 Protein expressed in HEK-293 Cells - ABIN2180562 : Iba, Albrechtsen, Gilpin, Fröhlich, Loechel, Zolkiewska, Ishiguro, Kojima, Liu, Langford, Sanderson, Brakebusch, Fässler, Wewer: The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading. in The Journal of cell biology 2000 (PubMed)
    Show all 4 references for 2180562

  2. Human ADAM12 Protein expressed in Human Cells - ABIN2003566 : Galliano, Huet, Frygelius, Polgren, Wewer, Engvall: Binding of ADAM12, a marker of skeletal muscle regeneration, to the muscle-specific actin-binding protein, alpha -actinin-2, is required for myoblast fusion. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for 2003566

More Proteins for ADAM12 Interaction Partners

Zebrafish ADAM Metallopeptidase Domain 12 (ADAM12) interaction partners

  1. results suggest that adam12 plays a significant role in the regulation of body growth during juvenile stage in zebrafish, although the precise molecular mechanisms await further study.

Mouse (Murine) ADAM Metallopeptidase Domain 12 (ADAM12) interaction partners

  1. In conclusion, MiR29a regulates endothelial cell ADAM12 upregulation in ischemia and this is impaired in hyperglycemia.

  2. It was concluded that TNF-alpha (show TNF Proteins)-induced changes in extracellular matix components increased expression of ADAM12 among other changes that were temporally related with the onset of myocyte function.

  3. ADAM12 and ADAM17 (show ADAM17 Proteins) are essential molecules for the impairment of barrier function of retinal vasculature under hypoxia.

  4. Augmentation of ADAM12 expression in vivo improved outcomes in Balb/c mice, whereas knockdown of ADAM12 made outcomes worse in C57Bl/6 mice. In vitro, ADAM12 expression modulates endothelial cell proliferation, survival, and angiogenesis.

  5. The effect of insulin-like growth factor-I (show IGF1 Proteins) on ADAM12 expression during the course of myogenesis is reported.

  6. Nitric oxide synthase deficiency has differential effects on ADAM12 expression in growing mouse brain.

  7. Inhibition of Erbb2 (show ERBB2 Proteins) suppressed the increase in metalloproteinase ADAM12 expression in skin tumors.

  8. TGF-beta (show TGFB1 Proteins) stimulation of renal cells results in a significant up-regulation of Adams 10, 17, 12, and 19

  9. ADAM12 enhanced ephrin-A1 (show EFNA1 Proteins) cleavage in response to transforming growth factor-betra1 in primary tumors.

  10. The endogenous SnoN (show SKIL Proteins) plays a role in regulating ADAM12 expression in response to TGFbeta1 (show TGFB1 Proteins).

Human ADAM Metallopeptidase Domain 12 (ADAM12) interaction partners

  1. The rs3740199 polymorphism in the ADAM12 gene was associated with knee osteoarthritis genetic susceptibility.

  2. These results indicate that ADAM12 actively supports the CSC phenotype in claudin-low breast cancer cells via modulation of the EGFR (show EGFR Proteins) pathway.

  3. We conclude that ADAM12 and MMP-14 (show MMP14 Proteins) are associated with cavernous sinus invasion in pituitary adenomas, which qualifies these proteins in diagnosis and therapy.

  4. ADAM12 expression is significantly upregulated in human masticatory mucosa during wound healing

  5. Stromal expression patterns for both ADAM12 and CDCP1 (show CDCP1 Proteins).

  6. The first trimester maternal ADAM12-s levels were statistically significantly higher in the entire ART group, IVF (show SCN5A Proteins) and ICSI groups, and normal cycle-frozen embryo transfer group when compared with those in the controls.

  7. The level of ADAM12 was upregulated in tumor tissues of breast cancer compared to that of adjacent normal tissues. patients with higher level of ADAM12 exhibited shorter survival time compared to that of low level of ADAM12

  8. The siRNA-directed loss of ADAM12 impedes spontaneous fusion of primary cytotrophoblasts, whereas overexpression of the secreted variant, ADAM12S, potentiates cell fusion in the Bewo trophoblast cell line.

  9. the present findings support the conclusion that the E2F1 transcription factor (show E2F1 Proteins) regulates the expression of ADAM12 by binding differential cis (show CISH Proteins)-acting elements.

  10. ADAM12L is associated with epithelial to mesenchymal transition (EMT (show ITK Proteins)) and contributes to TGF-beta (show TGFB1 Proteins)-dependent EMT (show ITK Proteins).

Cow (Bovine) ADAM Metallopeptidase Domain 12 (ADAM12) interaction partners

  1. These findings suggest ADAM12 is upregulated in muscles with more slow-oxidative myofibres, such as the LM, and is linked to type I myofibers in cattle.

  2. The 5'- and 3'-regions of bovive ADAM12 have been analysed and compared to the human gene, and the promoter region has been cloned and sequenced.

ADAM12 Protein Profile

Protein Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene has two alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. The shorter form is found to stimulate myogenesis.

Alternative names and synonyms associated with ADAM12

  • ADAM metallopeptidase domain 12 (ADAM12)
  • a disintegrin and metalloproteinase domain 12 (meltrin alpha) (adam12)
  • ADAM metallopeptidase domain 12 (adam12)
  • a disintegrin and metallopeptidase domain 12 (meltrin alpha) (Adam12)
  • ADAM metallopeptidase domain 12 (Adam12)
  • adam12 protein
  • MCMP protein
  • MCMPMltna protein
  • mKIAA4001 protein
  • MLTN protein
  • MLTNA protein

Protein level used designations for ADAM12

ADAM metallopeptidase domain 12 , ADAM metallopeptidase domain 12 (meltrin alpha) , a disintegrin and metalloproteinase domain 12 (meltrin alpha) , adam12a , ADAM 12 , a disintegrin and metalloprotease domain 12 , disintegrin and metalloproteinase domain-containing protein 12 , meltrin alpha , meltrin-alpha , ADAM12 short isoform , disintegrin and metalloprotease 12 , a disintegrin and metallopeptidase domain 12 (meltrin alpha)

450818 Pan troglodytes
563275 Danio rerio
677729 Xenopus (Silurana) tropicalis
696405 Macaca mulatta
11489 Mus musculus
8038 Homo sapiens
425843 Gallus gallus
407229 Bos taurus
679837 Rattus norvegicus
100686018 Canis lupus familiaris
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