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data indicate that ST034307 is a selective small-molecule inhibitor of AC1 and suggest that selective AC1 inhibitors may be useful for managing pain.
Genetic deletion of AC8 (adenylyl cyclase 8 (show ADCY8 ELISA Kits)) but not AC1 abolished long-lasting anxiety.
Following ethanol administration, phosphorylation of TrkB (show NTRK2 ELISA Kits) is significantly increased in the striatum of Adcyl1 and Adcyl6 knock-out mice.
Findings provide evidence to link activation of alpha7 nAChRs to a cAMP rise via AC1, which defines a new signaling pathway employed by alpha7 nAChRs
Results indicate that thalamic AC1 plays a major role in patterning and refinement of the mouse thalamocortical circuitry
Adenylyl cyclase-mediated effects contribute to increased isoprenaline-induced cardiac contractility in TRPM4 (show TRPM4 ELISA Kits)-deficient mice.
Results demonstrate that ADCY1 has an evolutionarily conserved role in hearing.
Data indicate that genetic ablation of RGS6 (show RGS6 ELISA Kits) expression resulted in anxiolytic and antidepressant behavior by enhancing signaling through the 5-HT1A receptor (show CC2D1A ELISA Kits)-adenylyl cyclase (AC) axis.
Contrast sensitivity is similarly reduced in Adcy1-/- mice.
These results suggest that AC1 in retinal ganglion cell axons mediates the development of retinotopy and eye-specific segregation in the superior colliculus and dorsal lateral geniculate nucleus.
STC1 (show STC1 ELISA Kits) interferes with CALCRL (show CALCRL ELISA Kits) signaling during osteoblastogenesis via adenylate cyclase inhibition.
AC1 catalytic activity can be adjusted by mediating calmodulin activation of AC1 by reversible methionine oxidation in calmodulin.
Increased expression of AC1 in the forebrain leads to deficits in behavioral inhibition.
AGS3 reduced D(2L)DR-mediated sensitization of AC1 and AC2.
Compartmentalized AC1-CFTR (show CFTR ELISA Kits) association is responsible for Ca(2 (show CA2 ELISA Kits)+)/cAMP cross-talk.
Tissue transglutaminase (show TGM2 ELISA Kits) directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB (show CREB ELISA Kits)) activation.
Transgenic mice overexpressing type-1 adenylyl cyclase in the forebrain show elevated long-term potentiation (LTP (show SCP2 ELISA Kits)), increased memory for object recognition and slower rates of extinction for contextual memory.
Expression of sensitization of AC1 involves Galpha (show SUCLG1 ELISA Kits)(s)-adenylyl cyclase interactions.
This gene encodes a form of adenylate cyclase expressed in brain. A similar protein in mouse is involved in pattern formation of the brain.
brain adenylate cyclase 1
, adenylate cyclase 1 (brain)
, adenylate cyclase type 1-like
, ATP pyrophosphate-lyase 1
, Ca(2+)/calmodulin-activated adenylyl cyclase
, adenylate cyclase type 1
, adenylate cyclase type I
, adenylyl cyclase 1
, 3',5'-cyclic AMP synthetase
, adenyl cyclase
, ca(2+)/calmodulin-activated adenylyl cyclase