Browse our AP2S1 Proteins (AP2S1)

Full name:
Adaptor-Related Protein Complex 2, sigma 1 Subunit Proteins (AP2S1)
On are 13 Adaptor-Related Protein Complex 2, sigma 1 Subunit (AP2S1) Proteins from 5 different suppliers available. Additionally we are shipping AP2S1 Antibodies (37) and AP2S1 Kits (2) and many more products for this protein. A total of 55 AP2S1 products are currently listed.
AI043088, AP2S1, Ap17, AP17-DELTA, CLAPS2, DDBDRAFT_0188542, DDBDRAFT_0234236, DDB_0188542, DDB_0234236, HHC3, MGC85224
list all proteins Gene Name GeneID UniProt
AP2S1 1175 P53680
AP2S1 232910 P62743
AP2S1 65046 P62744

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AP2S1 Proteins (AP2S1) by Origin

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Top referenced AP2S1 Proteins

  1. Human AP2S1 Protein expressed in Escherichia coli (E. coli) - ABIN1046568 : Winterpacht, Endele, Enklaar, Fuhry, Zabel: Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2-->q13.3. in Cytogenetics and cell genetics 1997 (PubMed)
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More Proteins for AP2S1 Interaction Partners

Human Adaptor-Related Protein Complex 2, sigma 1 Subunit (AP2S1) interaction partners

  1. CaSR (show CASR Proteins) and AP2S1 sequencing is worthwhile in patients with familial hyperparathyroidism and phenotype suggesting familial hypocalciuric hypercalcemia as it can diagnose up to 50% of cases.

  2. In 33 CASR (show CASR Proteins)-negative patients with suspected FHH (show CASR Proteins), Data found two (~6%) with a mutation in AP2S1 (p.Arg15Leu and p.Arg15His). Family screening confirmed the genotype-phenotype correlations. Data did not identify any pathogenic mutations in GNA11 (show GNA11 Proteins).

  3. our studies demonstrate AP2sigma2 mutations to result in a more severe FHH (show CASR Proteins) phenotype with genotype-phenotype correlations, and a dominant-negative mechanism of action with mutational bias at the Arg15 residue.

  4. The results affirm that a significant number of patients suspected of having Familial hypocalciuric hypercalcemia but proven negative for CASR (show CASR Proteins) mutation have AP2S1 p.R15 mutations.

  5. The absence of AP2S1 abnormalities in hypocalcemic patients, suggests that autosomal dominant hypocalcemia 3 (ADH3) may not occur or otherwise represents a rare hypocalcemic disorder.

  6. None of the 60 patients presented with nucleotidic changes or copy number variation in the AP2S1 gene, thereby excluding AP2S1 defects as a frequent cause of isolated hypoparathyroidism.

  7. Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3.

AP2S1 Protein Profile

Protein Summary

One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.

Alternative names and synonyms associated with AP2S1

  • adaptor-related protein complex 2, sigma 1 subunit (AP2S1)
  • adaptor-related protein complex 2, sigma 1 subunit (ap2s1)
  • adaptor-related protein complex 2, sigma 1 subunit (Ap2s1)
  • AI043088 protein
  • AP2S1 protein
  • Ap17 protein
  • AP17-DELTA protein
  • CLAPS2 protein
  • DDBDRAFT_0188542 protein
  • DDBDRAFT_0234236 protein
  • DDB_0188542 protein
  • DDB_0234236 protein
  • HHC3 protein
  • MGC85224 protein

Protein level used designations for AP2S1

adaptor-related protein complex 2, sigma 1 subunit , AP-2 complex subunit sigma , AP-2 complex subunit sigma isoform AP17 , sigma adaptin , HA2 17 kDa subunit , adaptor protein complex AP-2 subunit sigma , clathrin assembly protein 2 small chain , clathrin coat assembly protein AP17 , clathrin coat-associated protein AP17 , clathrin-associated/assembly/adaptor protein, small 2 (17kD) , plasma membrane adaptor AP-2 17 kDa protein , sigma2-adaptin , adapter-related protein complex 2 sigma subunit , sigma-adaptin 3b , clathrin-associated protein 17 , AP-2 complex subunit sigma-1

431511 Gallus gallus
456156 Pan troglodytes
549079 Xenopus (Silurana) tropicalis
716911 Macaca mulatta
8627289 Dictyostelium discoideum AX4
447078 Xenopus laevis
476427 Canis lupus familiaris
1175 Homo sapiens
232910 Mus musculus
65046 Rattus norvegicus
536553 Bos taurus
100172940 Pongo abelii
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