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DGKdelta deficiency impairs AMPK (show PRKAA1 ELISA Kits) signaling and lipid metabolism, thereby highlighting the deleterious role of excessive lipid metabolites in the development of peripheral insulin (show INS ELISA Kits) resistance and type 2 diabetes pathogenesis.
DGKD (show DGKQ ELISA Kits) preferably metabolizes palmitic acid-containing diacylglycerol species supplied from the PC-PLC (show HSPG2 ELISA Kits) pathway.
DGKdelta markedly increases lipid synthesis, at least in part as a result of promoting the synthesis of fatty acids.
These results suggest that DGKzeta (show DGKZ ELISA Kits) is involved in IQGAP1 (show IQGAP1 ELISA Kits)/Rac1-mediated phagocytosis upon LPS (show TLR4 ELISA Kits) stimulation in macrophages.
Results suggest that diacylglycerol kinase delta regulates epidermal growth factor (show EGF ELISA Kits) receptors by modulating protein kinase C (show PKC ELISA Kits) signaling.
Metabolic flexibility, evident by the transition between lipid and carbohydrate ut (show DGUOK ELISA Kits)ilization during fasted and fed conditions, was impaired in DGKdelta haploinsufficient mice.
Diacylglycerol signaling limits Akt activation through diacylglycerol kinase delta and PHLPP2.
This study demonistrated that the lack of association of DGKD SNPs with PD in the Han Chinese population.
Zinc site mutations impair DGKdelta localization to cytoplasmic puncta and enhance localization the plasma membrane.
Data indicate a novel mechanism where diacylglycerol kinase delta and protein kinase (show CDK7 ELISA Kits) Calpha (show PRKACA ELISA Kits) modulate the levels of ubiquitinated epidermal growth factor (show EGF ELISA Kits) receptors through Akt (show AKT1 ELISA Kits) and ubiquitin-specific protease 8 (show USP8 ELISA Kits).
Disruption of diacylglycerol kinase delta (DGKD) is associated with seizures in humans and mice.
Study identified reduced diacylglycerol kinase delta (DGKdelta) expression and DGK (show DGKB ELISA Kits) activity in skeletal muscle from type 2 diabetic patients.
Polymerization of DGK delta regulates the activity of the enzyme by sequestering DGK delta in an inactive cellular location.
This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms.
diacylglycerol kinase, delta 130kDa
, diacylglycerol kinase delta-like
, DAG kinase delta
, diacylglycerol kinase delta
, diglyceride kinase delta