Browse our anti-Geminin, DNA Replication Inhibitor (GMNN) Antibodies

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anti-Geminin, DNA Replication Inhibitor Antibodies (GMNN)
On are 108 Geminin, DNA Replication Inhibitor (GMNN) Antibodies from 22 different suppliers available. Additionally we are shipping Geminin, DNA Replication Inhibitor Proteins (14) and Geminin, DNA Replication Inhibitor Kits (2) and many more products for this protein. A total of 126 Geminin, DNA Replication Inhibitor products are currently listed.
anon-WO0257455.1, AW546347, CG3183, Dmel\\CG3183, Dm geminin, DyakGE24654, dyak_GLEANR_833, GB16871, GE24654, gem, geminin, GMNN, l(2)k14019, LOC100049517, sb:cb254, v(2)k09107, zgc:66217
list all antibodies Gene Name GeneID UniProt
GMNN 57441 O88513
GMNN 291137  
GMNN 51053 O75496

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Top referenced anti-Geminin, DNA Replication Inhibitor Antibodies

  1. Human Monoclonal GMNN Primary Antibody for ELISA, WB - ABIN165400 : Luo, Yang, Takihara, Knoetgen, Kessel: The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. in Nature 2004 (PubMed)
    Show all 2 references for 165400

  2. Human Monoclonal GMNN Primary Antibody for EIA, WB - ABIN121183 : Pitulescu, Kessel, Luo: The regulation of embryonic patterning and DNA replication by geminin. in Cellular and molecular life sciences : CMLS 2005 (PubMed)

  3. Human Polyclonal GMNN Primary Antibody for FACS, ELISA - ABIN1574066 : Wang, Kirschner: Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex. in Nature cell biology 2013 (PubMed)

  4. Human Polyclonal GMNN Primary Antibody for ICC, IF - ABIN251510 : Yim, Erikson: Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation. in Molecular and cellular biology 2009 (PubMed)

More Antibodies against Geminin, DNA Replication Inhibitor Interaction Partners

Fruit Fly (Drosophila melanogaster) Geminin, DNA Replication Inhibitor (GMNN) interaction partners

  1. In the absence of geminin, limited pre-replicative complex assembly was restricted to the heterochromatin by elevated cyclin A (show CCNA2 Antibodies)-CDK (show CDK4 Antibodies) activity.

  2. Gem and Brm (show SMARCA2 Antibodies) act antagonistically to modulate the EGFR (show EGFR Antibodies)-Ras-MAPK (show MAPK1 Antibodies) signaling pathway, by affecting Mek (show MAP2K1 Antibodies) levels during Drosophila development

  3. In cycling cells, Dup (show CDT1 Antibodies) destruction is coupled to DNA replication and that increased levels of Gem balance elevated Dup (show CDT1 Antibodies) levels to prevent pre-replicative complex reformation when Dup (show CDT1 Antibodies) degradation fails.

  4. Down-regulation of APC (show APC Antibodies)/C activity results in stabilization of Geminin protein and blocks endocycle progression.

Zebrafish Geminin, DNA Replication Inhibitor (GMNN) interaction partners

  1. results demonstrate that geminin is required for proper Kupffer's vesicle formation and ciliogenesis, thus playing an important part in setting up left-right asymmetry.

  2. Results from a dual-luciferase assay in HEK293 cells showed that ZDND increases the translation of geminin

Mouse (Murine) Geminin, DNA Replication Inhibitor (GMNN) interaction partners

  1. These results provide proof-of-principle that preventing geminin function could prevent malignancy in tumors derived from pluripotent cells by selectively eliminating the progenitor cells with little harm to normal cells.

  2. cell penetrating (CP) Geminin is imported into the nucleus after incorporation and also the incorporated CP-Geminin directly interacted with Cdt1 (show CDT1 Antibodies) or Brahma (show SMARCA2 Antibodies)/Brg1 (show SMARCA4 Antibodies) as the same manner as Geminin

  3. Study shows that ablation of Geminin induces massive rereplication as a result of unrestrained Cdt1 (show CDT1 Antibodies) activity in embryonic stem cells, whereas it has no such effect in embryonic fibroblasts in which alternative regulation of Cdt1 (show CDT1 Antibodies) activity is intact.

  4. Maternal geminin does not regulate oogenesis and oocyte meiotic maturation, but it does control accurate DNA replication and timely cleavage of fertilized eggs.

  5. Regulation of gene expression by geminin occurs only after pluripotent cells differentiate into cells in which geminin is not essential for viability.

  6. Geminin is an important regulator of self-renewal and survival of enteric nervous system progenitor cells.

  7. geminin is indispensable for fetal hematopoiesis and regulates the generation of a physiological pool of stem and progenitor cells in the fetal hematopoietic system.

  8. these data demonstrate a requirement for Geminin for neural tube patterning and neuronal differentiation during mammalian neurulation in vivo.

  9. geminin is required for Sox2 (show SOX2 Antibodies) expression, and thus for the maintenance of totipotency, pluripotency and the early neural lineage.

  10. geminin acts both like a component of the FGF4 (show FGF4 Antibodies) signal transduction pathway that governs trophoblast proliferation and differentiation, and geminin is required to maintain endocycles.

Human Geminin, DNA Replication Inhibitor (GMNN) interaction partners

  1. summarize current information on the molecular functions of Geminin and the regulatory system for Geminin protein expression, and argue for the molecular role of Geminin in cell fate determination of hematopoietic stem cells [review]

  2. Studies indicate that geminin expression is associated with different types of cancer.

  3. High geminin expression is associated with breast cancer.

  4. De novo GMNN mutations cause autosomal-dominant primordial dwarfism associated with Meier-Gorlin syndrome.

  5. Elevated Ki67 (show MKI67 Antibodies) and geminin expression distinguish a fraction of metastatic breast carcinoma with worse prognosis.

  6. geminin is indispensable for fetal hematopoiesis and regulates the generation of a physiological pool of stem and progenitor cells in the fetal hematopoietic system.

  7. These findings suggest that E2F (show E2F1 Antibodies)-mediated activation of Geminin transcription is negatively regulated by Geminin through the inhibition of chromatin remodeling.

  8. Bound Geminin prevents transition of the pre-replicative complexes to a state that is competent for initiation of DNA replication.

  9. Selective expression of geminin during the proliferative phase of the cell cycle and its nuclear specificity increase its potential to be used as an alternative marker of proliferation in breast cancer patients.

  10. Protein levels of Geminin and Cdt1 (show CDT1 Antibodies) are tightly regulated through the cell cycle, and the Cdt1 (show CDT1 Antibodies)-Geminin complex likely acts as a molecular switch that can enable or disable the firing of each origin of replication.

Geminin, DNA Replication Inhibitor (GMNN) Antigen Profile

Antigen Summary

This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.

Alternative names and synonyms associated with Geminin, DNA Replication Inhibitor (GMNN)

  • geminin-like (LOC100052598) antibody
  • geminin (LOC100351332) antibody
  • CG3183 gene product from transcript CG3183-RA (geminin) antibody
  • geminin, DNA replication inhibitor (gmnn) antibody
  • geminin protein (geminin) antibody
  • geminin, DNA replication inhibitor (GMNN) antibody
  • DyakGE24654-PA (Dyakgeminin) antibody
  • geminin (LOC100049517) antibody
  • geminin (Gmnn) antibody
  • geminin-like (LOC100515035) antibody
  • anon-WO0257455.1 antibody
  • AW546347 antibody
  • CG3183 antibody
  • Dmel\\CG3183 antibody
  • Dm geminin antibody
  • DyakGE24654 antibody
  • dyak_GLEANR_833 antibody
  • GB16871 antibody
  • GE24654 antibody
  • gem antibody
  • geminin antibody
  • GMNN antibody
  • l(2)k14019 antibody
  • LOC100049517 antibody
  • sb:cb254 antibody
  • v(2)k09107 antibody
  • zgc:66217 antibody

Protein level used designations for GMNN

CG3183-PA , CG3183-PB , geminin-PA , geminin-PB , geminin , geminin protein , geminin, DNA replication inhibitor , DyakGE24654-PA , Dyakgeminin-PA , GE24654-PA

100052598 Equus caballus
100351332 Oryctolagus cuniculus
35563 Drosophila melanogaster
368320 Danio rerio
410093 Apis mellifera
462477 Pan troglodytes
496859 Xenopus (Silurana) tropicalis
708416 Macaca mulatta
6528296 Drosophila yakuba
100049517 Oryzias latipes
57441 Mus musculus
291137 Rattus norvegicus
100515035 Sus scrofa
51053 Homo sapiens
478739 Canis lupus familiaris
526377 Bos taurus
421004 Gallus gallus
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