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Human GPER ELISA Kit for Sandwich ELISA - ABIN421646
Kajta, Litwa, Rzemieniec, Wnuk, Lason, Zelek-Molik, Nalepa, Grzegorzewska-Hiczwa, Tokarski, Golas, Guzik, Grochowalski, Szychowski, Wojtowicz: Isomer-nonspecific action of dichlorodiphenyltrichloroethane on aryl hydrocarbon receptor and G-protein-coupled receptor 30 intracellular signaling in apoptotic neuronal cells. in Molecular and cellular endocrinology 2014
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Mouse (Murine) GPER ELISA Kit for Sandwich ELISA - ABIN429004
Rzemieniec, Litwa, Wnuk, Lason, Go?as, Krzeptowski, Kajta: Neuroprotective action of raloxifene against hypoxia-induced damage in mouse hippocampal cells depends on ER? but not ER? or GPR30 signalling. in The Journal of steroid biochemistry and molecular biology 2014
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PKA and MEK (thus, also pERK) are the intracellular mediators downstream of GPR30 that induce the non-genomic suppression of GnRH-induced LH secretion from bovine AP cells by estradiol or G1
Estradiol can weakly modulate the motility and this effect is strictly associated with GPER and not with ESR1 (show ESR1 ELISA Kits) and ESR2 (show ESR2 ELISA Kits). The subcellular localization of GPER in the neck on stallion sperm is coherent with this effect.
The presence of a single isoform of ESR1 (show ESR1 ELISA Kits) (66kDa (show SF3A2 ELISA Kits)) and ESR2 (show ESR2 ELISA Kits) (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER in colt testis.
Utilizing both genetic and pharmacologic approaches, the authors establish that sex steroid effects on human melanin synthesis are mediated by the membrane-bound, steroid hormone receptors G protein-coupled estrogen receptor (show ESR1 ELISA Kits) (GPER), and progestin and adipoQ receptor 7 (PAQR7 (show PAQR7 ELISA Kits)).
These clinical data showed that the expression of G-protein coupled estrogen receptor (show ESR1 ELISA Kits) (GPER) is negatively associated with lymph node metastasis, high-grade tumor and fibronectin (FN (show FN1 ELISA Kits)) expression while positively associated with the favorable outcome in 135 triple negative breast cancer cells patients.
Data suggest that, under agonism of estrogens, ESR1 (show ESR1 ELISA Kits) exhibits a generally anxiogenic effect, ESR2 (show ESR2 ELISA Kits) exhibits a generally anxiolytic effect, and GPR30 exhibits both anxiogenic and anxiolytic effects. (ESR1 (show ESR1 ELISA Kits) = estrogen receptor 1/alpha (show ESR1 ELISA Kits); ESR2 (show ESR2 ELISA Kits) = estrogen receptor 2/beta (show ESR2 ELISA Kits); GPR30 = G protein-coupled estrogen receptor 1) [REVIEW]
Either by specific inhibitors for GPER, ERK (show EPHB2 ELISA Kits), AKT (show AKT1 ELISA Kits) and NF-kappaB (show NFKB1 ELISA Kits), or by knock-down of GPER.
The intron variant rs4265085 of GPER1 may confer risk for recurrent spontaneous abortion in Dai and Bai ethnic groups in China.
Activation of GPER can suppress migration and angiogenesis of triple negative breast cancer by inhibiting of NF-kappaB (show NFKB1 ELISA Kits)/IL-6 (show IL6 ELISA Kits) signaling.
GPER protects against hepatic tumorigenesis by regulating inflammatory responses.
GPER enhances melanogenesis via PKA by upregulating microphthalmia-related transcription factor-tyrosinase (show TYR ELISA Kits) in melanoma
Data suggest that GPR30 increases ERK1/2 activity via two Gi/o-mediated mechanisms, a PDZ-dependent constitutive mechanism and a PDZ-independent Gi/o-stimulated mechanism involving PI3K. (GPR30 = G protein-coupled estrogen receptor 1; ERK1 = extracellular signal-regulated kinase 1; ERK2 = extracellular signal-regulated kinase 2; Gi/0 = GTP-binding protein alpha subunits, Gi-Go; PI3K = phosphoinositide-3-kinase)
present study revealed that BPA (show DST ELISA Kits) can trigger the progression of laryngeal squamous cell carcinoma via GPER-mediated upregulation of IL-6 (show IL6 ELISA Kits). Therefore, more attention should be paid for the BPA (show DST ELISA Kits) exposure on the development of laryngeal cancer.
this study revealed a role for GPER activity in regulating Nox1 (show NOX1 ELISA Kits) abundance and associated O2(-)-mediated structural and functional damage that contributes to disease pathology
These findings provide strong evidence for aldosterone serving a causal role in renal cell cancer regulation via its GPER receptor; thus, antagonism of GPER represents a potential new target for treatment to reduce metastatic spread.
Data suggest that prenatal exposure to p,p'-DDT (show DDT ELISA Kits) (an endocrine disrupting pesticide) causes sex- and age-independent attenuation of Gper1 in brain which appears to play key role in propagation of DDT (show DDT ELISA Kits)-induced depressive-like neurotoxicity.
Study suggested that the neuroprotective effect of estrogen requires intact GPER1-associated signaling in an in vitro model of ischemia. The membrane-associated signaling mediates the estrogen actions, and depends on PI3K/Akt (show AKT1 ELISA Kits) signaling for Ask1 (show MAP3K5 ELISA Kits) inhibition that prevents the cell death triggered by ischemia. These mechanisms may help for a therapeutic strategy to target on GPER1 for the treatment of neurological disorders.
Phosphorylation of myosin regulatory light chain triggered by E2 was found to be mediated by estrogen receptor-beta (show ESR2 ELISA Kits) and the G protein-coupled estrogen receptor (show ESR1 ELISA Kits).
Our study demonstrated the ameliorative role of GPR30 in NOR memory impaired by AD pathology in female mice
identified a novel regulatory mechanism through which the endogenous Gper facilitates the age-dependent increase in myocardial expression of ECE-2 (show ECE2 ELISA Kits) and the ETB (show EDNRB ELISA Kits) receptor, which is compatible with an activating role of GPER for the local endothelin system with aging
We suggest that activation of GPER exerts an inhibitory effect on colonic motility by promoting nitric oxide release from myenteric nitrergic nerves
GPR30 is expressed in diverse intracellular compartments in undifferentiated and differentiated C2C12 cells and mediates estradiol actions.
This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein that localizes to the endoplasmic reticulum. The protein binds estrogen, resulting in intracellular calcium mobilization and synthesis of phosphatidylinositol 3,4,5-trisphosphate in the nucleus. This protein therefore plays a role in the rapid nongenomic signaling events widely observed following stimulation of cells and tissues with estrogen. Alternate transcriptional splice variants which encode the same protein have been characterized.
G protein-coupled estrogen receptor 1
, G-protein coupled estrogen receptor 1-like
, G protein-coupled receptor 30
, G-protein coupled estrogen receptor 1
, G-protein coupled receptor 30
, IL8-related receptor DRY12
, chemoattractant receptor-like 2
, chemokine receptor-like 2
, constitutively expressed peptide-like receptor
, flow-induced endothelial G-protein coupled receptor 1
, heptahelix receptor
, leucine rich protein in GPR30 3'UTR
, lymphocyte-derived G-protein coupled receptor
, membrane estrogen receptor
, constitutively expressed peptide-like receptor like
, G-protein coupled receptor 41