Browse our GRB7 Proteins (GRB7)

Full name:
Growth Factor Receptor-Bound Protein 7 Proteins (GRB7)
On are 11 Growth Factor Receptor-Bound Protein 7 (GRB7) Proteins from 7 different suppliers available. Additionally we are shipping GRB7 Antibodies (104) and GRB7 Kits (20) and many more products for this protein. A total of 143 GRB7 products are currently listed.
GRB7, mKIAA4028
list all proteins Gene Name GeneID UniProt
GRB7 14786 Q03160
GRB7 84427 Q9QZC5
GRB7 2886 Q14451

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GRB7 Proteins (GRB7) by Origin

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More Proteins for GRB7 Interaction Partners

Mouse (Murine) Growth Factor Receptor-Bound Protein 7 (GRB7) interaction partners

  1. GRB7 gene expression in uterus during embryo implantation is regulated by Mmu-miR (show MLXIP Proteins)-193.

  2. Findings illustrate an underlying mechanism by which Grb7 promotes tumorigenesis through the formation of a novel EGFR (show EGFR Proteins)-Grb7-Ras signaling complex, thereby highlighting the potential strategy of targeting Grb7 as an anti-breast cancer therapy.

  3. The adaptor Grb7 links netrin-1 (show NTN1 Proteins) signaling to regulation of mRNA translation of kappa opioid receptor (show OPRK1 Proteins).

  4. Grb7 is identified as an integral component of stress granules.

Human Growth Factor Receptor-Bound Protein 7 (GRB7) interaction partners

  1. Suggest close relationship between Grb7 gene amplification and GRB7 protein overexpression in human ovarian cancer. Immunohistochemistry might have limited diagnostic value in these tumors compared to fluorescence in situ hybridization.

  2. Grb7 was found to be significantly related to the biological classification of breast cancer

  3. apo (show C9orf3 Proteins) Grb7 SH2 domain crystallized in the trigonal space group P63 (show RPE65 Proteins), whereas the G7-B1-Grb7 SH2 domain complex crystallized in the monoclinic space group P21 (show CDKN1A Proteins)

  4. The data reveal that Grb7 plays an important role in breast cancer progression, beyond the context of HER2 (show ERBB2 Proteins)+ve cell types

  5. Grb7 protein interacts with Filamin-a, an actin-crosslinking component of the cell cytoskeleton.

  6. Data suggest that calmodulin (show CALM1 Proteins) controls Grb7-mediated cell migration.

  7. Data propose the phosphorylation state of Grb7-SH2 domain tyrosine residues could control Grb7 dimerization, and dimerization may be an important regulatory step in Grb7 binding to RTKs such as erbB2 (show ERBB2 Proteins).

  8. GRB7 is a context-dependent oncogene (show RAB1A Proteins), which modulates the ERBB2 (show ERBB2 Proteins) signaling pathway through enhanced phosphorylation of ERBB2 (show ERBB2 Proteins) and Akt (show AKT1 Proteins).

  9. propose that CaM (show CALM1 Proteins) inhibits the translocation of Grb7 to the nucleus after binding to its CaM (show CALM1 Proteins)-BD and therefore occluding its overlapping NLS (show ALDH1A2 Proteins)

  10. A series of Grb7 SH2 domain-binding nonphosphorylated peptides in the yeast two-hybrid system, were identified.

GRB7 Protein Profile

Protein Summary

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with GRB7

  • growth factor receptor-bound protein 7 (GRB7)
  • growth factor receptor bound protein 7 (Grb7)
  • growth factor receptor bound protein 7-like (LOC100355891)
  • growth factor receptor-bound protein 7 (Grb7)
  • GRB7 protein
  • mKIAA4028 protein

Protein level used designations for GRB7

growth factor receptor-bound protein 7 , growth factor receptor-bound protein 7-like , GRB7 adapter protein , Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) , epidermal growth factor receptor GRB-7 , growth factor receptor binding protein GRB7 , B47

454637 Pan troglodytes
100392059 Callithrix jacchus
100448630 Pongo abelii
100479529 Ailuropoda melanoleuca
100603732 Nomascus leucogenys
14786 Mus musculus
84427 Rattus norvegicus
100355891 Oryctolagus cuniculus
2886 Homo sapiens
100725019 Cavia porcellus
100513230 Sus scrofa
508847 Bos taurus
491021 Canis lupus familiaris
426597 Gallus gallus
101104589 Ovis aries
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